Clinical trials: Pain Reduction
Pain
Efficacy of a New Topical Anesthetic
A new topical anesthetic which contains 5% lidocaine and a disinfection ingredient has been developed and is tested in this study (LidoDyn).
- Trial name
- NCT00562211
- Testing
- LidoDyn, EMLA creme
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Pain, Venipuncture
Comparison of Synera Patch Versus LMX-4 Cream Versus Placebo Patch for Pain Reduction During Venipuncture in Children
The purpose of this study is to compare the effect of Synera patch versus LMX-4 cream and placebo on the level of pain, observed distress, difficulty of venipuncture and skin side effects in children undergoing intravenous blood…
- Conditions
- Pain, Venipuncture, Anesthetics, Local
- Trial name
- NCT01115062
- Testing
- Synera Patch, LMX 4 Cream
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Carol Morreale
Cervical Biopsy
Role of Oral Tramadol 50 mg in Reducing Pain During Colposcopy-directed Cervical Biopsy
The study objective is to evaluate the effectiveness of oral tramadol 50 mg in reducing pain during the colposcopy-directed cervical biopsy.half of the patients will receive oral tramadol tablets and the other half will receive a…
- Trial name
- NCT03532841
- Testing
- an oral tramadol 50 mg(Tramal, Memphis, Giza, Egypt) tablet
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cairo University
Irriversible Pulpitis
Analyzing the Impact of Occlusal Reduction on the Pain Following Root Canal Therapy in Molar Teeth With and Without Pain in Turkish Patients.
Introduction: This study aimed to compare the intensity of postoperative pain after single-visit root canal treatment of symptomatic or asymptomatic teeth following occlusal reduction.
- Trial name
- NCT06953856
- Testing
- occlusal reduction
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Pain Management
The Effect of Mindfulness-Based Stress Reduction Training Before Mastectomy on Postoperative Pain in Early Period
This research aims to investigate the effect of mindfulness-based stress reduction training given before mastectomy on postoperative early period pain and the fear of movement caused by pain.
- Trial name
- NCT06349395
- Testing
- MBSR surgical nursing care
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Contraception
Comparative Safety and Efficacy of Vaginal Misoprostol Versus Lidocaine-prilocaine Cream in Levonorgestrel IUD Insertion
the aim of the present study is to compare the safety and Efficacy of vaginal misoprostol versus Lidocaine-prilocaine cream in reducing pain during levonorgestrel IUD Insertion in women delivered only by cesarean deliveries
- Trial name
- NCT04339348
- Testing
- vaginal misoprostol, Lidocaine-Prilocaine Topical cream
- Where
- Egypt
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cairo University
Analgesic Effects of Music
The Sedative Effects of Music Listening on Pain During Cold Pressor Test
This study aims to understand whether listening to music can reduce pain and anxiety caused by a cold-temperature stimulus in healthy young adults (n = 30).
- Trial name
- ESEMP (NCT07515196)
- Testing
- Phase 1 - Silence (Baseline), Phase 2 - Happy Mode with Measured Rhythm, Phase 3 - Sad Mode with Measured Rhythm
- Where
- Lebanon
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rawane El Dimachki
Pain
Effect of Topical Application of Clove Gel Versus Benzocaine Gel on Pain Reduction During Application of Simple Dental Procedures in Children.
This study is aimed to evaluate the effectiveness of the topical application of clove gel versus topical application of 20% benzocaine gel in pain reduction in children undergoing dental treatment (rubber dam or matrix band…
- Trial name
- NCT05507359
- Testing
- clove gel, Benzocaine gel
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Pain, İnjection
Comparison of the Efficacy of Shotblocker and Acupressure in Reducing Pain Due to Intramuscular Injection
Various non-pharmacological approaches are used in the relief of pain caused by intramuscular injection. Shotblocher and acupressure, which are among these methods, are easy to apply.More evidence-based studies are needed to…
- Conditions
- Acute Pain, İnjection, Acupressure, Alternative Medicine
- Trial name
- NCT05456945
- Testing
- acupressure application, Shotblocher
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Pain, Postoperative
Multimodal Orthognathic Study Comparing Use of Exparel With Standard of Care.
A prospective, randomized clinical trial to determine if using liposomal bupivicaine in maxillary orthognathic procedures can reduce the post-operative use of opioids as well as improving the patient's quality of life, versus…
- Trial name
- NCT06499181
- Testing
- Liposomal bupivacaine, Bupivacain, Epinephrin
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pain
Buffered Lidocaine in Paracervical Blocks
For pain relief during a first trimester surgical aspiration, most providers use the paracervical block, either alone or in combination with other pain control techniques.
- Trial name
- NCT03107754
- Testing
- Lidocaine, Lidocaine-Sodium Bicarbonate
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Nasal Fracture
Efficacy of L/A Spray andL/A-soaked Nasal Packings on Postoperative Pain After Nasal Closed Reduction
This study is perfored to investigate the efficacy of preoperative lidocaine spray and lidocaine-bupivacaine mixture-soaked nasal packing for acute postoperative pain after nasal closed reduction surgery.
- Trial name
- NCT03733275
- Testing
- Lidocaine
- Where
- 2 sites in South Korea
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Opioid Dependence
DE-eSCALation of Opioids Post-surgical dischargE
The Descale Study aims to: 1. Look at the prescribing trends of opioids and the scale of long-term use following surgery within East Kent (United Kingdom) 2.
- Trial name
- DESCALE (NCT06396663)
- Testing
- Rapid Opioid de-escalation, Gradual Opioid de-escalation, Continuation of opioids
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Kent
Pain Management, Fear
Distraction Methods for Reducing Pain and Fear During Blood Draw in Children
Blood draw is a common invasive procedure that can cause pain and fear in children. This randomized controlled trial aims to compare the effects of pinwheel blowing, 3D hologram viewing, and sugar-free gum chewing on pain and…
- Trial name
- PED-DISTRACT (NCT07770191)
- Testing
- 3D Hologram Viewing, Pinwheel Blowing, Gum Chewing
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Gülsev Kutman
Arthropathy of Knee, Pain, Joint
Assessing if Cryoneurolysis Improves Prehabilitation and Decreases Pain After Surgery With Less Opioid Use in TKA Patients
This is a prospective, randomized control trial to evaluate the impacts of preoperative cryoneurolysis treatment on opioid consumption with prehabilitation and resulting postoperative functional improvement in patients undergoing…
- Conditions
- Arthropathy of Knee, Pain, Joint, Arthritis Knee, Opioid Use
- Trial name
- NCT03836313
- Testing
- iovera°
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Osteopathic Manipulative Treatment
By Potentially Adding a Century Old Therapeutic Measure to Pain Treatment Regimens Called Osteopathic Manipulative Treatment, Can Help Decrease Muscle and Bone Pain and the Usage of Opioid Pain Medication.
Osteopathic Manipulative Treatment (OMT) has been used to successfully treat patients for over a hundred years. Even though there have been many subjective clinical results, there is still little research measuring the actual…
- Trial name
- NCT06930196
- Testing
- Counterstrain, Muscle Energy, High Velocity Low Amplitude
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Skagit Regional Health
Virtual Reality, Patient Experience
Virtual Reality for Mindfulness and Anxiety Reduction in Fertility Procedures
This study aims to evaluate the effectiveness of a Virtual Reality (VR)-based mindfulness and meditation intervention in reducing anxiety among patients undergoing fertility-related surgical procedures.
- Trial name
- NCT07014267
- Testing
- Intervention Group (Virtual Reality intervention)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Anxiety Disorder of Childhood or Adolescence
Music to Decrease Pain and Anxiety During Head CTs Performed at the PEds ED
A single blinded controlled trial to determine if an intervention of listening to nursery songs with integrated heart beat sounds results in changes in anxiety level in infants and young children less than four years of age in an…
- Trial name
- NCT02437214
- Testing
- Use of music for anxiety in children
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Steven Weiss
Post Operative Pain, Nausea and Vomiting, Postoperative
ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery
This is a single center, prospective, double-blinded randomized controlled trial comparing the efficacy of bilateral superficial cervical plexus blocks (BSCPB) with local wound infiltration vs placebo with local wound…
- Conditions
- Post Operative Pain, Nausea and Vomiting, Postoperative, Opioid Use
- Trial name
- NCT05805423
- Testing
- bilateral superficial cervical plexus blocks and local wound infiltration
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of California, Davis