Clinical trials: Pain Response
Jet Injection, Local Anasthesia
This Study Evaluate the Patient Response to Jet Injection, Pain and Satisfaction Compared to Conventional Method of Local Anasthesia Especially in Maxillary Teeth
Pain during administration of local anesthesia remains one of the major concerns in dental practice, often leading to anxiety and treatment avoidance.
- Trial name
- NCT07581249
- Testing
- Non aspirating dental syringe, The use of jet injection
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Pain
Electrical Stimulation of Accessory Spinal Nerve in Cortical Activation and Autonomic Response in Healthy Subjects
This randomized, crossover sham controlled trial with sham intended to study the effect of electrical stimulation on peripheral nerve (spinal accessory nerve) with acupuncture needle in healthy subjects aims to access the effect…
- Trial name
- NCT03295370
- Testing
- Electrical Stimulation
- Where
- Brazil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Children Who Need Circumcision
Assessment of Hemodynamic Response in Surgery of Circumcision in Children
The surgery stress relives systemic inflammatory response by hormones and adrenergic receptors. When the pro-inflammatory mediator is higher than anti-inflammatory response, the physiologic status is impaired and the patient is…
- Trial name
- NCT00943475
- Testing
- circumcision
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of Juiz de Fora
Pain, Acute, Pain, Neuropathic
Exercise and Pain in Non-Hispanic Blacks and Whites
Non-Hispanic Blacks tend to report higher levels of pain, experience pain more frequently, and be under-treated for pain compared to non-Hispanic Whites.
- Conditions
- Pain, Acute, Pain, Neuropathic, Analgesia, Aerobic Exercise
- Trial name
- NCT03609957
- Testing
- Aerobic Exercise Training, Interval Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Georgia State University
Meditation, Pain
Study of Affect Induction for Lab Induced Pain in Healthy Undergraduates
The goal of this clinical trial is to test if a mindfulness-enhanced positive affect induction (MPAI) works well to reduce pain intensity and pain unpleasantness from a cold water pain test in undergraduate college students who…
- Conditions
- Meditation, Pain, Mindfulness, Affect
- Trial name
- NCT05619419
- Testing
- Mindfulness-enhanced positive affect induction, Breathing Meditation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pain Thresholds, Healthy Adult Participants
Evaluation of Psychophysical Responses After Mechanical Stimulation.
This study evaluates the test-retest reliability of psychophysical responses to non-injurious sharp stimuli applied via a robotic system.
- Trial name
- NCT07774429
- Testing
- Robot-controlled non-injurious mechanical stimulation
- Where
- Argentina
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Patellofemoral Pain Syndrome
Pain and Movement Responses to Resistance Training to Muscular Failure in Patients With Patellofemoral Pain
This study aims to investigate the effect of training to muscular failure in patients with patellofemoral pain (PFP). In a cross-sectional observational design, participants with PFP will be be performing a knee exercise to…
- Trial name
- NCT07812519
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ted Gunhamn
Pain
Breast Feeding Analgesia in Preterm Infants
The purpose of this study is to compare the effects of mothers' breastfeeding with the effects of pacifier sucking on preterm infant biobehavioural responses during and immediately after a painful procedure Hypothesis: 1.
- Trial name
- NCT00175409
- Testing
- Blood collection
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Magnetic Resonance Imaging, Neuronal Activity
Perception of Baby's Painful Cry in fMRI
Crying is the primary signaling strategy available to the human newborn for eliciting parental care. Yet, the investigators only have superficial understanding of the information carried by cries, and how this information is…
- Trial name
- NCT03190486
- Testing
- functional Magnetic Resonance Imaging (fMRI)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fibromyalgia
The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia
The major goal of this study is to determine if the innate immune response is dysregulated in people with fibromyalgia, compared to healthy controls.
- Trial name
- NCT04263454
- Testing
- Endotoxin, Escherichia Coli, Magnetic Resonance Spectroscopy
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis, Knee
Nutramax Joint Health Formulation Biochemical Response Study
The Nutramax test article is a nutritional supplement that contains several ingredients shown to potentially provide benefit to patients suffering from a painful and sometimes debilitating condition of the knee called…
- Trial name
- NCT02614274
- Testing
- Nutraceutical joint health formulation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pain, Withdrawal
Evaluation of the Effect of Venous Diameter Measurement by Ultrasonography on Pain and Withdrawal Response
During general anesthesia, intravenous (IV) medications can disrupt the patient's comfort by causing a pain sensation or a withdrawal response in the heart.
- Trial name
- VDIAMETER (NCT03376308)
- Testing
- Pain Score, Withdrawal movement score, hemodynamic response
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Acute Nociceptive Pain, Hyperalgesia
Pain Response to Cannabidiol in Opioid-induced Hyperalgesia, Acute Nociceptive Pain and Allodynia By Using a Model Mimicking Acute Pain in Healthy Adults
Prospective, randomized, placebo-controlled, double-blinded, crossover study to investigate the effect of cannabidiol (CBD) on remifentanil-induced hyperalgesia in healthy volunteers in a well-established acute pain model.
- Conditions
- Acute Nociceptive Pain, Hyperalgesia, Allodynia, Opioid-induced Hyperalgesia
- Trial name
- CANAB II (NCT04059978)
- Testing
- CBD, Remifentanil
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Kinesiophobia (Fear of Movement), Musculoskeletal Injuries
Binaural Beats Stimulation on the Autonomic Nervous System (ANS), Kinesiophobia and Fitness Levels in Professional Athletes With Musculoskeletal (MSK) Injuries
The purpose of the current study is to investigate the effectiveness of binaural beat stimulation on the autonomic nervous system (ANS), taking into account kinesiophobia related to reinjury and fitness levels in professional…
- Trial name
- ANS MSK HRV (NCT07370636)
- Testing
- Auditory stimulation with binaural beats and guidance, Auditory stimulation without binaural beats, Auditory stimulation with background music
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of West Attica
Acute Pain
Minimum Local Anesthetic Volume of Bupivacaine in Labour Epidurals
Different medications can be used as analgesics in labor epidurals. Bupivacaine is one of the most commonly used drugs for that purpose. The efficacy of a certain medication injected epidurally depends on the dose that is given.
- Trial name
- NCT00450099
- Testing
- bupivacaine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Neck Pain Musculoskeletal, Chronic Neck Pain
Clinical and Brain Activity Assessment Before and After Physiotherapy in People With Chronic Non-specific Neck Pain
The goal of this clinical trial is to investigate whether electroencephalographic features are associated with the multidimensional clinical characteristics of adults with chronic non-specific neck pain and whether clinical and…
- Trial name
- NCT07756229
- Testing
- Manual physiotherapy and neck-specific exercise programme
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ander Cervantes Benítez
Impacted Third Molar Tooth, Pain, Acute
Variability in Analgesic Response to Ibuprofen
Nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, are recommended as first-line treatment for post-surgical dental pain.
- Trial name
- NCT06539741
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Respiratory Depression
Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo.
The purpose of this study is to explore and compare VRH after administration of Belbuca, Oxycodone HCl and Placebo in recreational opioid users.
- Trial name
- NCT03996694
- Testing
- Belbuca 300 µg, Belbuca 600 µg, Belbuca 900 µg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- BioDelivery Sciences International
Shoulder Arthroscopy, Pain
Intravenous Dexamethasone on Supraclavicular Brachial Plexus Block for Shoulder Arthroscopy
Previous studies have confirmed that IV dexamethasone prolongs brachial plexus blocks. However, these studies only used fixed doses of IV dexamethasone at relatively high doses, which could potentially lead to increased glucose…
- Trial name
- SCB & IV Dex (NCT02688530)
- Testing
- IV Saline, IV Dexamethasone 4mg, IV Dexamethasone 6mg
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Pain Sensation, Hyperalgesia
Pain Response to Cannabidiol in Induced Acute Nociceptive Pain, Allodynia and Hyperalgesia By Using a Model Mimicking Acute Pain in Healthy Adults
This study is to investigate the effect of CBD on acute pain in healthy volunteers in a well-established acute pain model.
- Conditions
- Pain Sensation, Hyperalgesia, Allodynia
- Trial name
- CANAB I (NCT03985995)
- Testing
- CBD 800 mg p.o
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland