Clinical trials: Pain Sensitivity
Headache Migraine Chronic
Spectacle Tints and Thin-Films for Migraine
Nearly all migraine sufferers report sensitivity to light during a headache and a significant proportion of sufferers report light sensitivity between attacks. Light is also a common trigger for migraine headaches.
- Trial name
- NCT02720211
- Testing
- Gray tinted spectacle lenses, Thin-Film spectacle lenses
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Inflammatory Bowel Diseases, Chronic Pain
Somatosensory Profiles in Individuals With Persistent Musculoskeletal Pain and Inflammatory Bowel Disease
This study evaluates nervous system hypersensitivity in individuals with inflammatory bowel disease (IBD) and experiences of ongoing musculoskeletal (MSK) pain.
- Conditions
- Inflammatory Bowel Diseases, Chronic Pain, Central Sensitization
- Trial name
- NCT03799471
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pain, Inflammatory Response
Association Between Body Composition and Pain in Spinal Cord Injury
The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and…
- Trial name
- NCT05459207
- Testing
- Moderate Fat Meal, High Fat Meal
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Insulin Resistance
The Effect of 12-week Circuit Training on Insulin Sensitivity and Endothelial Function in Women With Insulin Resistance
During the last 10 years many studies concerning the impact of physical training on whole-body insulin sensitivity have been published, but there is a lack of an extended investigation on the potential clinical benefits of novel…
- Trial name
- NCT04528693
- Testing
- Circuit training (combination of strength and endurance exercises)
- Where
- Poland
- Volunteers
- 49 people
- Sponsor
- Poznan University of Physical Education
Low Back Pain
Kettlebell Swings & Low Back Pressure Pain Threshold
The purpose of this study is to determine whether a high intensity kettlebell workout, utilizing a Tabata protocol format, can decrease objective measures of pain pressure threshold in subjects without low back pain.
- Trial name
- NCT03696615
- Testing
- Tabata Kettlebell Swing Workout, Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Posttraumatic Headache
Hypersensitivity to Adrenomedullin in Post-Traumatic Headache
Adrenomedullin is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether adrenomedullin induces headache with migraine-like features in people with persistent post-traumatic headache (PTH)…
- Trial name
- NCT07059546
- Testing
- Adrenomedullin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Neuropathic Pain
Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation).
- Trial name
- ALLO (NCT02858479)
- Testing
- stimulation on painful area (area allodynic), same stimulation on non-painful area, MRI scan
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fatigue Syndrome, Chronic, Fibromyalgia
Pain Inhibition in Patients With Rheumatoid Arthritis and Central Sensitivity Syndromes
Both patients with peripheral structural pathologies, like rheumatoid arthritis (RA)-patients, or patients with central sensitivity syndromes (CSS) suffer chronic pain.
- Conditions
- Fatigue Syndrome, Chronic, Fibromyalgia, Arthritis, Rheumatoid
- Trial name
- NCT01154647
- Testing
- citalopram, 1 ml 0.9 % NaCl
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Central Sensitisation, Postoperative Pain
Evaluation of the Effect of Central Sensitivity on Pain and Functional Status After Total Knee Joint Replacement Surgery
The study is a prospective observational study designed to determine the effects of central sensitization on pain and functional status of patients before and after total knee joint replacement surgery.
- Conditions
- Central Sensitisation, Postoperative Pain, Arthritis
- Trial name
- NCT06553118
- Testing
- Total knee arthroplasty
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Pain
Validation of the Turkish Version of the Pain Sensitivity Questionnaire
The Pain Sensitivity Questionnaire(PSQ) is a self-rating measure for the assessment of pain sensitivity and has been developed by Dr. R. Ruscheweyh in Germany.
- Trial name
- NCT03609788
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medeniyet University
Myofascial Pain Syndromes, Myofascial Trigger Point Pain
Kinesio Taping for Upper Trapezius Myofascial Trigger Points
Myofascial pain syndrome is one of the most common causes of musculoskeletal pain, and the upper trapezius is the muscle most frequently affected in the neck and shoulder region.
- Conditions
- Myofascial Pain Syndromes, Myofascial Trigger Point Pain, Neck Pain
- Trial name
- NCT07790042
- Testing
- Kinesio Taping (muscle inhibition technique)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Pamukkale University
Bladder Pain and Discomfort, Urinary Urgency and Frequency
Sensory Sensitivity and Urinary Symptoms in the Female Population
Bladder pain and discomfort, as well as urinary urgency and frequency, are bothersome symptoms seen frequently in the general population.
- Conditions
- Bladder Pain and Discomfort, Urinary Urgency and Frequency, Bothersome Symptoms
- Trial name
- NCT01978002
- Testing
- Pain sensitivity testing, Urodynamic testing
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pain Thresholds
Does Boredom With Simultaneously Perceived Pain Affect Pressure Pain Thresholds
The purpose of this study is to investigate if different emotional states such as boredom and happiness could influence mechanical pain thresholds and other pain - related variables such as pain tolerance, pain intensity and pain…
- Trial name
- BPPPT (NCT07330167)
- Testing
- Boredom intervention, Humorous
- Where
- Sweden
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Linnaeus University
Hamstring Tightness
IASTM vs. Static Stretching for Hamstring Tightness: Short- and Long-Term Effects
This study compares two treatments for people with tight hamstring muscles (the muscles at the back of the thigh): instrument-assisted soft tissue mobilization (IASTM) and static stretching.
- Trial name
- IASTM-HT (NCT07838844)
- Testing
- Instrument-Assisted Soft Tissue Mobilization, Static Stretching
- Volunteers
- 46 people
- Sponsor
- GÖKHAN MARAŞ
Acute Coronary Syndrome, Chest Pain
High-Sensitivity Cardiac Troponin T to OPtimize Chest Pain Risk Stratification
This is a prospective observational cohort study of ED patients with acute chest pain or other symptoms suggestive of ACS. Blood samples will be collected from study participants for High-Sensitivity Cardiac Troponin T (hs-cTnT)…
- Trial name
- STOP CP (NCT02984436)
- Testing
- Blood Sample, HEART Score
- Where
- 6 sites in United States
- Volunteers
- 1,572 people
- Sponsor
- University of Florida
Knee Arthritis, Hip Arthritis
Preoperative Pain Threshold and Rapid Recover Programs
To investigate the association between grip strength and preoperative pain threshold as measured by pressure algometer and validated pain outcome surveys.
- Trial name
- NCT02740738
- Testing
- Wagner Pain Algometer, Dynamometer
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Pain Threshold, Pain Tolerance
Acute Effects of LLLT on Pain Threshold and Pain Tolerance
Pain is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Low-Level Laser…
- Conditions
- Pain Threshold, Pain Tolerance, Acute Pain, Low-level Laser Therapy
- Trial name
- NCT07422272
- Testing
- Low-Level Laser Therapy (LLLT)
- Where
- Cyprus
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- European University of Lefke
Ectopic Pregnancy
The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy
The experiment aims to explore the clinical effect of subclinical doses of ketamine on early postoperative pain sensitivity in ectopic pregnancy population.
- Trial name
- NCT06559280
- Testing
- esketamine
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Fujian Provincial Hospital
Tension-Type Headache
Efficacy of Kinesio Taping in Tension Type Headache
Aim: The purpose of this study was to investigate the efficacy of Kinesio taping on upper trapezius muscle on the reduction of pain and emotional state in the treatment of patients with tension type headache by acting on…
- Trial name
- NCT03665142
- Testing
- Kinesio taping, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Istanbul Bilgi University
Pain
Hypoalgesic Effect of Electrical Current and Cervical Manipulation
This study evaluates the hypoalgesic effect of the TENS application associated with joint manipulation of the cervical region in healthy individuals.
- Trial name
- NCT03531541
- Testing
- Application of TENS, CJM
- Where
- 2 sites in Brazil
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos