Clinical trials: Pain Sensitivity
Inflammatory Bowel Diseases, Chronic Pain
Somatosensory Profiles in Individuals With Persistent Musculoskeletal Pain and Inflammatory Bowel Disease
This study evaluates nervous system hypersensitivity in individuals with inflammatory bowel disease (IBD) and experiences of ongoing musculoskeletal (MSK) pain.
- Conditions
- Inflammatory Bowel Diseases, Chronic Pain, Central Sensitization
- Trial name
- NCT03799471
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Low Back Pain
Kettlebell Swings & Low Back Pressure Pain Threshold
The purpose of this study is to determine whether a high intensity kettlebell workout, utilizing a Tabata protocol format, can decrease objective measures of pain pressure threshold in subjects without low back pain.
- Trial name
- NCT03696615
- Testing
- Tabata Kettlebell Swing Workout, Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Fatigue Syndrome, Chronic, Fibromyalgia
Pain Inhibition in Patients With Rheumatoid Arthritis and Central Sensitivity Syndromes
Both patients with peripheral structural pathologies, like rheumatoid arthritis (RA)-patients, or patients with central sensitivity syndromes (CSS) suffer chronic pain.
- Conditions
- Fatigue Syndrome, Chronic, Fibromyalgia, Arthritis, Rheumatoid
- Trial name
- NCT01154647
- Testing
- citalopram, 1 ml 0.9 % NaCl
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Bladder Pain and Discomfort, Urinary Urgency and Frequency
Sensory Sensitivity and Urinary Symptoms in the Female Population
Bladder pain and discomfort, as well as urinary urgency and frequency, are bothersome symptoms seen frequently in the general population.
- Conditions
- Bladder Pain and Discomfort, Urinary Urgency and Frequency, Bothersome Symptoms
- Trial name
- NCT01978002
- Testing
- Pain sensitivity testing, Urodynamic testing
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pain Thresholds
Does Boredom With Simultaneously Perceived Pain Affect Pressure Pain Thresholds
The purpose of this study is to investigate if different emotional states such as boredom and happiness could influence mechanical pain thresholds and other pain - related variables such as pain tolerance, pain intensity and pain…
- Trial name
- BPPPT (NCT07330167)
- Testing
- Boredom intervention, Humorous
- Where
- Sweden
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Linnaeus University
Pain Threshold, Pain Tolerance
Acute Effects of LLLT on Pain Threshold and Pain Tolerance
Pain is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Low-Level Laser…
- Conditions
- Pain Threshold, Pain Tolerance, Acute Pain, Low-level Laser Therapy
- Trial name
- NCT07422272
- Testing
- Low-Level Laser Therapy (LLLT)
- Where
- Cyprus
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- European University of Lefke
Pain
Hypoalgesic Effect of Electrical Current and Cervical Manipulation
This study evaluates the hypoalgesic effect of the TENS application associated with joint manipulation of the cervical region in healthy individuals.
- Trial name
- NCT03531541
- Testing
- Application of TENS, CJM
- Where
- 2 sites in Brazil
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Pain Threshold, Surgery
The Effect of Remifentanil on the Objectively Measured Pressure Pain Threshold
It is a clinical study investigating the relationship between objectively measured pain threshold and the need for escalating doses of remifentanyl opioids. This study is expected to include approximately 40 participants.
- Conditions
- Pain Threshold, Surgery, Postoperative Pain, Intravenous Anesthesia
- Trial name
- NCT07568405
- Testing
- Pressure pain theshold measured under remifentanil (ultiva®) infusion, Postoperative PCA IV morphine (Sterop®) consumption and adverse events history
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Nursing Caries, Pain
The Effect of Hand Puppets and Kaleidoscope on Pain and Fear in Preschool Children
This study aimed to determine the effects of hand puppets and kaleidoscopes on some emotional parameters in preschool children who underwent skin prick testing at the pediatric allergy and immunology outpatient clinic.The study…
- Conditions
- Nursing Caries, Pain, Fear of Pain
- Trial name
- NCT06512857
- Testing
- Hand puppet method, Kaleidoscope method
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Firat University
Intellectual Disability
Characterization of Nociception Phenotype in Individuals With Intellectual Disability
Background: People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain.
- Trial name
- NCT05473429
- Testing
- TSA2 Thermosensory Stimulator
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Primary Headache Disorders, Tension Headache
Pericranial and General Sensitivity in Patients With Primary Headache
Primary headaches such as migraine and tension type headache are among the most common neurological disorders and frequently cause significant disability and reduced quality of life.
- Conditions
- Primary Headache Disorders, Tension Headache, Tension-type Headache, Migraine
- Trial name
- HEAD-TMD (NCT07514208)
- Testing
- Pericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Pain Threshold, Stretching
The Effect of Stretching Intensity on Pain Sensitivity
The primary objective of this study is to determine the immediate efficiency of stretching intensity on regional and distant pain sensitivity in healthy subjects.
- Conditions
- Pain Threshold, Stretching, Pain Sensitivity, Range of Motion
- Trial name
- NCT05989490
- Testing
- Static stretching
- Where
- Denmark
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University College of Northern Denmark
Plantar Fasciitis, Chronic, Tibial Nerve
Tibial Nerve Size and Clinical Features in Chronic Plantar Fasciitis
This cross-sectional observational study aims to examine the relationship between tibial nerve cross-sectional area at the tarsal tunnel and plantar fascia thickness, pressure pain threshold, foot posture, and functional status…
- Trial name
- NCT07878273
- Testing
- Pressure Pain Threshold Assessment, Plantar fascia ultrasonographic Assessment, Tibial nerve ultrasonographic assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Pharmacological Action (PA)
The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects
1. To examine whether Ritalin has analgesic properties in healthy subjects. 2. To examine if Ritalin analgesic effect is a pain specific phenomenon or a part of a broader, non-specific effect on high mental functions.
- Trial name
- NCT01914822
- Testing
- methylphenidate hydrochloride
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Dental Pain, Muscle Sensitivity to Pressure
Analgetic Effect of Nitrousoxide-oxygen Inhalation for Dental Treatment of Children
To assess the analgetic effect of nitrousoxide-oxygen inhalation on pain perception in 12-15 years old children from 1) the dental pulp; 2) the masseter muscle; 3) the skin on the upper lip
- Conditions
- Dental Pain, Muscle Sensitivity to Pressure, Skin Sensitivity to Electric Stimulation
- Trial name
- NCT01022294
- Testing
- Nitrousoxide-oxygen and atmospheric air, Atmospheric air; nitrousoxide-oxygen
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Whiplash, Whiplash Injury
Changes of Pain Sensitivity During Rehabilitation of Patients Suffering From Whiplash Associated Disorders
This study investigates the sensory profile of people suffering from whiplash associated disorders (WAD) during rehabilitation.
- Conditions
- Whiplash, Whiplash Injury, Neck Pain, Healthy
- Trial name
- NCT03784196
- Testing
- Conservative rehabilitation
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
Covid19
Self- Versus Conventional-swabbing for COVID-19 Screening (COVISWAB)
Self-swabbing requires less personal protective equipment and could allow to test more people and even to do quick self-diagnosis if antigenic tests are available.
- Trial name
- COVISWAB (NCT04831853)
- Testing
- nasopharyngeal swabbing procedure (self swabbing first), nasopharyngeal swabbing procedure (conventionnal swabbing first)
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Hyperalgesia, Pain Perception
Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model
Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing.
- Conditions
- Hyperalgesia, Pain Perception, Central Nervous System Sensitization, Pain Threshold
- Trial name
- TS-OA-Cap (NCT07625475)
- Testing
- Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Healthy
A Phase 1 Study of FZ008-145 in Healthy Subjects.
The study will be conducted in 5 parts: Part A and Part B (single ascending dose [SAD] in solution formulation and tablet respectively), Part D and Part D2 (cold pressor test [CPT] to evaluate pain tolerance following single…
- Trial name
- NCT06685809
- Testing
- FZ008-145 solution, FZ008-145 Tablet
- Where
- Australia
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Guangzhou Fermion Technology Co., LTD