Clinical trials: Pain Severity
Irritable Bowel Syndrome (IBS)
Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
The objective is to evaluate whether ONO-2952 modulates visceral pain perception produced by rectal distention in female patients with IBS-D
- Trial name
- RESTORE (NCT01887002)
- Testing
- ONO-2952
- Where
- 4 sites in United States
- Volunteers
- 39 people
- Sponsor
- Ono Pharma USA Inc
Chronic Low Back Pain
Efficacy and Safety of Hydrocodone Bitartrate (HYD) in Subjects With Moderate to Severe Chronic Low Back Pain
The primary objective of this study is to evaluate the analgesic efficacy and safety of HYD tablets 20 to 120 mg once-daily dose compared to placebo in subjects with moderate to severe chronic low back pain uncontrolled by their…
- Trial name
- NCT01452529
- Testing
- Hydrocodone bitartrate q24h film-coated tablets
- Where
- 102 sites in United States
- Volunteers
- 905 people
- Sponsor
- Purdue Pharma LP
Dizziness, Nausea
Efficacy of a Transcranial Vibrating System for Mitigation of Migraine Associated Vertigo
Vertigo is among the most common symptoms associated with migraine and affects 26.5% of migraine sufferers, leading to a dramatic impact in life limiting even the most simple activities.
- Conditions
- Dizziness, Nausea, Headache, Confusion
- Trial name
- NCT03886012
- Testing
- Otoband
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Otolith Labs
Coronary Artery Disease, Angina Pectoris
An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery
The primary objective of this study is to evaluate sternal bone healing following a full median sternotomy versus standard of care for sternal closure with wire cerclage.
- Conditions
- Coronary Artery Disease, Angina Pectoris, Cardiac Valve Disease
- Trial name
- SB (NCT01783483)
- Testing
- SternaLock Blue closure system, Suture Wire
- Where
- 12 sites in United States
- Volunteers
- 236 people
- Sponsor
- Zimmer Biomet
Angina Pectoris, Coronary Heart Disease
Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction
Objective to evaluate the effect of Shexiang Baoxin Pill on myocardial ischemia in patients with coronary microvascular dysfunction (non obstructive coronary heart disease) through a randomized, double-blind, placebo-controlled…
- Conditions
- Angina Pectoris, Coronary Heart Disease, X Syndrome, Angina, Non Obstructive Coronary Artery Disease
- Trial name
- NCT04984954
- Testing
- MUSK pill
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Severe Knee Pain, Severe Knee Disability
Persona Revision Knee System EMEA PMCF Study
The purpose of this post-market clinical follow-up study is to confirm the long-term safety, performance and clinical benefits of the Persona Revision Knee System Implants and Instrumentation in revision Total Knee Arthroplasty.
- Conditions
- Severe Knee Pain, Severe Knee Disability, Revision Arthroplasty
- Trial name
- NCT07843966
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 238 people
- Sponsor
- Zimmer, GmbH
Chronic Pain, Insomnia
The Efficacy of CALPXT96™in Improving Sleep Quality in Patients With Chronic Non-cancer Pain
California Poppy has been traditionally used in Herbal Medicine as an analgesic, mild sedative and/or sleep aid. However there are no human clinical trial data to support its use.
- Trial name
- CALPXT96 (NCT02232256)
- Testing
- CALPXT96
- Where
- Canada
- Sponsor
- 9305-9954 Quebec Inc
Pain
Efficacy and Safety of Ralfinamide in Patients With Chronic Neuropathic Low Back Pain
The aim of the study is to determine if an experimental drug, ralfinamide, relieves your neuropathic low back pain, and if it demonstrates superiority to placebo, a "dummy" or sugar pill that contains no active medication.
- Trial name
- NCT01019824
- Testing
- Ralfinamide
- Where
- United Kingdom
- Volunteers
- 411 people
- Sponsor
- Newron Pharmaceuticals SPA
Pain
Omnitram Pharmacokinetic Study In Healthy Volunteers
The purpose of this study is to compare the safety, pharmacokinetic properties (the absorption, distribution and excretion), and analgesic activity of Omnitram (10 mg tablets), Tramadol (Ultram, 50 mg tablet) following oral…
- Trial name
- NCT02205554
- Testing
- Omnitram, Tramadol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Syntrix Biosystems, Inc.
Acute Postoperative Pain, Dental Pain
A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction
The primary objective of this trial is to assess the safety and tolerability of single, ascending doses of CYT-1010 in healthy male and female volunteers and in the treatment of acute postoperative pain after third molar…
- Trial name
- NCT07905105
- Testing
- CYT-1010
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cytogel Pharma, LLC
Small Fiber Neuropathy
A Study to Evaluate the Efficacy and Safety of VX-150 in Treating Subjects With Pain Caused by Small Fiber Neuropathy
This is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group, multicenter study evaluating the efficacy of VX-150 for the treatment of pain caused by small fiber neuropathy.
- Trial name
- NCT03304522
- Testing
- VX-150
- Where
- 34 sites in United States, Germany and 2 more
- Volunteers
- 89 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain, Fatigue
Acute Effect of Sound Healing on Pain, Fatigue and Mood
There is evidence that sound healing improves health and well-being. However, sound healing modalities, such as tuning forks, continue to be understudied, especially among people with chronic illnesses.
- Conditions
- Pain, Fatigue, Mood Change
- Trial name
- NCT05795322
- Testing
- Sound healing with tuning forks
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Innowage Limited
Dentine Hypersensitivity
Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity
A study to compare the efficacy of a test dentifrice against a control dentifrice in reducing dentinal hypersensitivity over a two week treatment period.
- Trial name
- NCT01592851
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcohol Abuse, Alcohol Abuse/addiction
A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder
This study will evaluate the safety and exploratory efficacy of AFA-281 in patients with Alcohol use disorder on cravings, subjective response to alcohol, pain thresholds, anxiety, depression, and sleep.
- Conditions
- Alcohol Abuse, Alcohol Abuse/addiction, Anxiety, Pain Threshold
- Trial name
- NCT06710431
- Testing
- AFA-281
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Afasci Inc
Chronic Pain
A Single Arm, Open-label First In Human Study for Assessing the Safety and Performance of the EpiFinder in Subjects With Clinical Indication for Lumbar Epidural Steroids Injection (ESI)
The EpiFinder device, which is the investigational device in this study, is intended for use in epidural procedures, between a luer syringe and an epidural needle, to give the treating physician a clear indication that the needle…
- Trial name
- NCT04047927
- Testing
- EpiFinder
- Where
- 2 sites in Israel
- Volunteers
- 15 people
- Sponsor
- Omeq Medical
Painful Diabetic Neuropathy, Diabetic Neuropathy
Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy
The purpose of the study is to determine whether clonidine gel is an effective treatment for reducing the pain associated with painful diabetic neuropathy.
- Conditions
- Painful Diabetic Neuropathy, Diabetic Neuropathy, Neuropathy
- Trial name
- NCT02068027
- Testing
- Clonidine Gel 0.1%
- Where
- 23 sites in United States
- Volunteers
- 260 people
- Sponsor
- BioDelivery Sciences International
Knee Osteoarthritis
Evaluation of the Evolution of Biological and Imaging Markers of Bone and Cartilage Degradation in Patients With Knee Osteoarthritis Receiving Intra-articular Injections of a Hyaluronan Derivative HYMOVIS®
This pilot study MOKHA is aimed to evaluate the beneficial effect of HYMOVIS® on cartilage of patients suffering of knee osteoarthritis as revealed by using scientifically sound, objective measurements of biological and MRI-based…
- Trial name
- MOKHA (NCT04293861)
- Testing
- HYMOVIS
- Where
- 8 sites in Belgium, France
- Volunteers
- 50 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Ankle Sprain
HKT-500 in the Treatment of Adult Patients With Ankle Sprain
The objective of this study is to demonstrate the multiple-dose efficacy and safety of HKT-500 for the treatment of ankle sprain.
- Trial name
- NCT00927641
- Testing
- Ketoprofen Patch
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Pain, Post-surgical
Analgesic Efficacy Of Valdecoxib In Patients Following Bunion Surgery
To assess the analgesic efficacy and general safety of 2 dosing regimens of valdecoxib compared to placebo on the first post-operative day in patients with moderate or severe pain following bunionectomy surgery.
- Trial name
- NCT00653354
- Testing
- valdecoxib
- Where
- 21 sites in United States
- Volunteers
- 360 people
- Sponsor
- Pfizer
Joint Pain
A Study to Evaluate the Efficacy of E-PR-01 on Musculoskeletal Health in Physically Active Individuals
The present study is a randomized, placebo-controlled, parallel-group, double-blind (double-dummy) clinical study. Not more than 210 individuals will be screened, and considering a screening failure rate of 18%, approximately 168…
- Trial name
- NCT05825222
- Testing
- E-PR-01 (Low dose), E-PR-01 (High Dose)
- Where
- 6 sites in India
- Volunteers
- 157 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
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