Clinical trials: Pain Threshold
Pain
Mechanistic Study of Duloxetine in Breast Cancer Patients With Chronic Pain
Early stage breast cancer is typically treated with surgery, chemotherapy, radiation therapy, and/or endocrine therapy. Following treatment, 25-60% of breast cancer survivors have reported chronic pain, which can be difficult to…
- Trial name
- NCT01912612
- Testing
- Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan Rogel Cancer Center
Pain, Hypogonadism
Effects of Testosterone Replacement on Pain Sensitivity and Pain Perception
Naturally occurring opiates (endorphins) decrease testosterone levels by inhibiting the synthesis of gonadotropin releasing hormone (GnRH) and also inhibiting testosterone synthesis by the testes.
- Trial name
- TAP (NCT00351819)
- Testing
- AndroGel
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Boston University
Sensitivity
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
- Trial name
- SensoryFLO (NCT03283072)
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Knee Osteoarthritis, Chronic Pain
Motor Cortex Plasticity and the Effect of Deep Intramuscular Needling Stimulation Therapy (DIMST) in Osteoarthritis Pain
The aim of this study is to evaluate the cortical excitability in pain of knee osteoarthritis (OA), as well as the effect of one session of a kind of electroacupuncture (deep needling intramuscular stimulation therapy - DIMST) in…
- Trial name
- NCT01855958
- Testing
- DIMST
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Myofascial Trigger Point Pain (MTrP)
Percutaneous Microelectrolysis on Myofascial Trigger Points Pain.
The aim of the design is to investigate the value of percutaneous microelectrolysis (MEP) as an analgesic technique in myofascial trigger points.
- Trial name
- MEP (NCT03636386)
- Testing
- Percutaneous microelectrolysis, Ultrasound therapy
- Where
- Chile
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Quiropraxia y Equilibrio
Breast Cancer, Pain
Pilot Study to Evaluate the Effect of Aromatase Inhibitor Therapy on Pain Threshold in Breast Cancer Patients
Postmenopausal women who have hormone receptor positive breast cancer are typically treated with aromatase inhibitor medications, which substantially decrease the amount of estrogen produced by their bodies.
- Conditions
- Breast Cancer, Pain, Arthralgia
- Trial name
- NCT01814397
- Testing
- Anastrozole, exemestane, letrozole
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan Rogel Cancer Center
Hyperalgesia
Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids
This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil).
- Trial name
- NCT01222091
- Testing
- Propranolol, Remifentanil
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pain
Unmodulated 5 Kilohertz Currents Versus TENS: Effect on Pain Thresholds, Tactile Threshold, and Nerve Conduction
The purpose of this study is to determine whether the transcutaneous application of unmodulated 5 Kilohertz (KHz) alternating currents are effective in decreasing the thermal and mechanical experimental pain and cause changes in…
- Trial name
- NCT02320838
- Testing
- 5 KHz, TENS
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Back Pain, Radiculopathy Lumbar
Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy
SNRB, as measured by the change in pain and objective functional ability, can solicit crucial information regarding a patient's clinical picture and can predict a patient's outcome post-surgery.
- Conditions
- Back Pain, Radiculopathy Lumbar, Degenerative Lumbar Spinal Stenosis
- Trial name
- NCT03801356
- Testing
- Selective Nerve Root Block
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The Cleveland Clinic
Pain, Surgery
The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population
Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population.
- Trial name
- NCT01950078
- Where
- China
- Volunteers
- 1,533 people, healthy volunteers welcome
- Sponsor
- Xianwei Zhang
Hamstring Injury, Muscle Tone Increased
Cranial Laser Reflex Technique for Hamstring Function
Purpose: To conduct a pilot study of the effect of Cranial Laser Reflex Technique (CLRT) compared with sham laser on hamstring muscle flexibility, strength, and pain pressure threshold.
- Conditions
- Hamstring Injury, Muscle Tone Increased, Muscle Pain, Muscle Weakness
- Trial name
- CLRTHam (NCT03044106)
- Testing
- CLRT
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Knee Osteoarthritis
Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis
This research is being done to evaluate whether combining medications that are FDA approved, but have not yet been approved for combination treatment, can be effective in reducing pain.
- Trial name
- NCT03098563
- Testing
- Blinded study medication
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Pain, Neuropathic, Pain, Acute
Ice Immersion Using Virtual Reality & Augmented Reality
The purpose of this study is to evaluate the effectiveness of different technologies, Virtual Reality and Augmented Reality with modifications as passive content, active content, cognitive load modulation, and positive…
- Trial name
- NCT04196686
- Testing
- VR/AR, Ice Bath
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pain
Mirthful Laughter and Muscle Soreness / Pain
The purpose of this study is first to investigate the effect of a controlled intervention with a comedy video on pain tolerance in a social setting while quantitatively measuring laughter in a young healthy population…
- Trial name
- NCT02896075
- Testing
- 30 Minute Comedy Video, 30 Minute Documentary Video
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Healthy
Comparing the Effects of Upper and Lower Body Resistance Training on Pain Sensitivity
Resistance exercise may immediately lessen the perception of pain. The purpose of this study is compare the effects of an upper body exercise to a lower body exercise on the perception of pain (pressure pain threshold).
- Trial name
- NCT05985382
- Testing
- Lower Body Resistance Exercise, Upper Body Resistance Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Dental Anxiety
Efficacy of an Internet-based Intervention for Dental Anxiety
The overall objective of the activities described in this protocol is to examine the efficacy of the Internet-based intervention in the reduction of dental anxiety in patients seeking dental treatment.
- Trial name
- NCT03680755
- Testing
- Internet-based intervention for dental anxiety
- Where
- United States
- Volunteers
- 503 people
- Sponsor
- Temple University
Surgery, Individuality
The Realtime Detection for Individual Variation of Analgesic ：A Comparison of Sufentanil vs Fentanyl
Purpose: This study aimed to find a quick and timely way to investigate the individual variation of efficacy of opioid analgesic in Chinese patients undergoing elective surgeries.
- Trial name
- NCT01748071
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Painful Peripheral Diabetic Neuropathy
A Study to Evaluate PEMF Therapy on Experimentally Inducted Pain in Subjects With Painful Peripheral Diabetic Neuropathy
Evaluate the effectiveness of the Provant Therapy System compared to sham on pain sensitivity and nervous system response to various qualities of experimentally induced pain in the upper and lower extremities of subjects with…
- Trial name
- NCT02809911
- Testing
- Provant
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Regenesis Biomedical, Inc.
No Disease State or Condition
Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers
The purpose of this study is to determine if the topical application to gingival tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT03233737
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Healthy
The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold
Oxytocin is neurohypophysial peptide that acts mainly as a neuromodulator in the brain.The vast majority of basic science studies suggested a large effect of oxytocin in minimizing acute pain.Few studies have demonstrated an…
- Trial name
- NCT02550093
- Testing
- Intervention 1, Washout Period, Intervention 2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwestern University