Clinical trials: Palliative Radiotherapy, active
Metastatic Spinal Cord Compression
To Determine Whether it is Feasible to Treat Patients Requiring Urgent Radiotherapy Diagnosed With Metastatic Cord Compression (MSCC) on the Magnetic Resonance Linear Accelerator (MRL) in a Single Appointment and Compare it to the Standard of Care Radiotherapy Pathway
The goal of this clinical trial is to understand whether the Magnetic Resonance Linear Accelerator (MRL) could expedite Radiotherapy treatment for Metastatic Cord Compression (MSCC) by removing the need for a planning CT (pCT)…
- Trial name
- RESONATE (NCT06965101)
- Testing
- Radiotherapy to the spine in a single appointment
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- The Christie NHS Foundation Trust
mCRC
Radiotherapy Combined QL1706, TAS-102 and Bevacizumab in mCRC
This single-center, single-arm, prospective study plans to enroll patients with advanced colorectal cancer who have failed first-line or higher systemic therapies.
- Trial name
- NCT07116577
- Testing
- Palliative radiotherapy, Iparomlimab and tuvonralimab, TAS-102
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Jinan Central Hospital
Bone Metastases in Subjects With Advanced Cancer, Radiotherapy
Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial
Rationale: With improvements in systemic tumour-directed treatments for primary tumours, survival rates for patients with bone metastases are improving.
- Trial name
- TIPZO-RT (NCT06805396)
- Testing
- Palliative Care Consult
- Where
- 5 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Roxanne Gal
Radiation Toxicity, Chemotherapeutic Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms, who have been referred to the HUGCDN Chronic Pain Unit for adjuvant palliative treatment with…
- Conditions
- Radiation Toxicity, Chemotherapeutic Toxicity, Chemotherapy-induced Peripheral Neuropathy, Delayed Wound Healing
- Trial name
- EPOOzo (NCT05417737)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Bernardino Clavo, MD, PhD
Palliative Radiotherapy
Advanced Techniques For Single-fraction Palliative Radiotherapy Versus Standard Multi Fraction Radiation
The aim of the study is to determine if single fraction dose escalated palliative radiotherapy results in a prolonged duration of benefit for patients otherwise suitable for Multifraction (5-10#) palliative radiation.
- Trial name
- ASPIRE_Multi (NCT04649125)
- Testing
- dose escalation
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Royal North Shore Hospital
Metastatic Breast Cancer
Study of Palliative Radiation Combined with Pembrolizumab in Unresectable Metastatic Stage IV Breast Cancer
This is a phase 2, open-label, single-arm trial designed to evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in combination with pembrolizumab following disease progression after two prior lines of…
- Trial name
- NCT04990921
- Testing
- Palliative Radiation and Pembrolizumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Palliative Radiotherapy, Radiotherapy, Intensity-Modulated
Advanced Techniques for Single-fraction Palliative Radiotherapy Versus ASPIRE-single
One third of patients treated in the radiation oncology departments are treated with palliative intent. These patients can be unwell due to their advanced disease and suffering from pain and other symptoms related to metastases.
- Trial name
- ASPIRE single (NCT04658537)
- Testing
- Radiation Therapy
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Royal North Shore Hospital
Cervical Cancer
Concomitant Curcumin Palliative Radiotherapy in Advanced Cervical Cancer Trial
The goal of this clinical trial is to test curcumin as an adjunct treatment in patients with cervical cancer receiving standard-of-care palliative radiation. The main questions it aims to answer are: 1.
- Trial name
- CuPRAC (NCT05947513)
- Testing
- Curcumin, Palliative radiotherapy
- Where
- Ethiopia
- Volunteers
- 27 people
- Sponsor
- Addis Ababa University
Rectal Cancer
Hypofractionated Palliative Radiotherapy in Patients With Advanced Non-operable Rectal Cancer
Many patients with rectal cancer were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases.
- Trial name
- NCT03853733
- Testing
- rectal cancer radiotherapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Consorci Sanitari de Terrassa
Esophageal Cancer
A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study
The purpose of this study is to investigate the effects of the addition of the stereotactic body radiotherapy and durvalumab to a well tolerated 2 week chemotherapy and radiation treatment regimen in people with esophageal cancer…
- Trial name
- PALEO (NCT06290505)
- Testing
- Durvalumab
- Where
- 9 sites in Australia, New Zealand
- Volunteers
- 54 people
- Sponsor
- Australasian Gastro-Intestinal Trials Group
Patients With Symptomatic or Bulky Tumors (More Than 8 cm) or With Tumors Resistant to Radiation
GRID Therapy as Palliative Radiation for Patients With Advanced and Symptomatic Tumors
Palliative radiation therapy represents 40% of the on-going radiation at the Jewish General Hospital. In a traditional palliative radiation treatment to bulky or radioresistant tumors, radiotherapy schema varies from 24 to 30 Gys…
- Trial name
- NCT02333110
- Testing
- spatially fractionated radiation therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Solid Tumor, Metastatic Cancer
A Study of RP-3500 in Combination With Standard Radiation Therapy in People With Solid Tumor Cancer
The purpose of this study is to test the safety of the study drug, RP-3500 when given in combination with palliative external beam radiotherapy (EBRT) to people who have metastatic solid tumor cancer with a mutation of the ATM…
- Trial name
- NCT05566574
- Testing
- RP-3500, External Beam Radiotherapy (EBRT)
- Where
- 7 sites in United States
- Volunteers
- 49 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer, Metastatic Cancer
Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors
The purpose of this research study is to determine if lattice radiation therapy (LRT) will provide better treatment for bulky (large) tumors than current standard of care radiotherapy.
- Conditions
- Cancer, Metastatic Cancer, Locally Advanced, Locally Advanced Solid Tumor
- Trial name
- NCT06416007
- Testing
- Lattice therapy (LRT)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Cincinnati
Metastases, Metastatic Cancer
Trial Comparing LATTICE Radiotherapy vs Moderately Dose-escalated Palliative Radiation for Patients With Metastases.
Unblinded, randomized study of 5-fraction LATTICE radiotherapy (20 Gy with an SIB to 66.7 Gy in 5 fractions) versus moderately dose-escalated palliative radiation (25 Gy in 5 fractions)
- Trial name
- NCT07594431
- Testing
- LATTICE Radiotherapy, Standard radiotherapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stanford University
Palliative Radiotherapy, Metastatic Cancer (Different Solid Tumour Types)
Hybrid Arc Palliative Radiation Therapy (HART): A Single Arm Phase II Trial
This is a prospective single-center single-arm Phase II trial of HART for patients with metastatic cancer. The primary objective is to assess the incidence of acute GI toxicity following HART.
- Trial name
- HART (NCT06778408)
- Testing
- Hybrid Palliative Radiation Therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Vermont Medical Center
Head and Neck Cancer
"QUAD SHOT" Radiotherapy With Pembrolizumab in Patients With Recurrent Head & Neck Cancer
The purpose of this study is to test the safety of palliative "QUAD SHOT" radiotherapy combined with pembrolizumab and evaluate the effects of the combination treatment patients with recurrent cancer of head and neck.
- Trial name
- QUADSHOT (NCT04373642)
- Testing
- Pebrolizumab + QUADSHOT Radiotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Oklahoma
Palliative Care
Evaluation of Toxicities in Patients Treated With Palliative Radiotherapy at Policlinico Sant Orsola of Bologna.
The aim of the study is to assess the outcome in palliative patients, particularly in terms of symptom resolution or alleviation, after radiation treatment of the various tumours analysed, in relation to the treatment setting…
- Trial name
- NCT06760806
- Where
- Italy
- Volunteers
- 7,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Spine Metastases
Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease
Early palliative care has been shown to improve the quality of life and even survival for patients with metastatic cancer. More and more supportive oncology teams in cancer centers now advocate for early integration of radiation…
- Trial name
- PROMISSeD (NCT05534321)
- Testing
- Prophylactic Radiotherapy, Standard of care systemic therapy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Baptist Health South Florida
Head and Neck Cancer
Development and Application of a Nurse-Led Preemptive Symptom Management Protocol for Head and Neck Cancer Patients Undergoing Radiation Therapy
The aim of this study is to investigate whether a nurse-led preemptive symptom management protocol can reduce the radiation therapy interruption rate in patients with head and neck cancer compared to conventional care models.
- Trial name
- NCT07467083
- Testing
- Nurse-led preemptive symptom management, Concentional care
- Where
- China
- Volunteers
- 170 people
- Sponsor
- West China Hospital
Cancer Metastatic
Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy for Painful Non-Spine Bone Metastases
This study is being done to answer the following question: Is Stereotactic Body Radiation Therapy or SBRT (a form of radiation therapy which can deliver high doses of radiation to the specific painful area of the body most…
- Trial name
- NCT06391242
- Testing
- Standard Conventional Radiotherapy, Stereotactic Body Radiotherapy
- Where
- 12 sites in Canada
- Volunteers
- 230 people
- Sponsor
- Canadian Cancer Trials Group