Clinical trials: Palliative Sedation
End of Life
Survey on Palliative Care and Law Perception
The primary objective of the current survey study is to obtain detailed information about European intensive care unit (ICU) clinicians' awareness of palliative care and relevant, local end-of-life (EoL) legislation.
- Trial name
- PCLAW (NCT06245525)
- Testing
- This is not an interventional study
- Where
- Greece
- Volunteers
- 523 people
- Sponsor
- University of Athens
Locally Advanced Cancer, Metastatic Cancer
Identification of In-hospital Patients in Need of Palliative Care Using a New Simplified Screening Tool
Every day many patients affected by chronic life-limiting illnesses are admitted into Internal Medicine wards, coming from the Emergency Department.
- Conditions
- Locally Advanced Cancer, Metastatic Cancer, Chronic Respiratory Failure, Chronic Heart Failure
- Trial name
- SST2017 (NCT04143230)
- Testing
- Screening for PC by means of two different screening tools
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Palliative Care
Sodium Oxybate Versus Midazolam for Comfort Sedation
The study aims at deepen the proof level of sodium oxybate use for comfort sedation at the end of life in a palliative care unit by comparing it to midazolam in a prospective randomized study with blinded efficacy evaluation.
- Trial name
- ONAMI (NCT05085873)
- Testing
- Sodium Oxybate injection, Midazolam injection
- Where
- Monaco
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Analgesia, Sedation
Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care
Dexmedetomidine is allowed in Switzerland for intravenous (IV) medication in the intensive care unit in the adult patient. Its active molecule, Dexmedetomidine (Dex), is a selective and powerful α2-Adrenoreceptors (AR) agonist…
- Conditions
- Analgesia, Sedation, Anxiolysis
- Trial name
- INDEX (NCT03151863)
- Testing
- Opioids, Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- Walid HABRE
COVID-19 Infection, Sars-cov-2
Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection
The current sars-cov-2 epidemic is responsible for severe respiratory infections leading to end-of-life situations. Dexmedetomidine may be indicated in mild to moderate sedation in palliative patients, due to its pharmacological…
- Conditions
- COVID-19 Infection, Sars-cov-2, Respiratory Failure, Palliative Situation
- Trial name
- PRODEX (NCT04350086)
- Testing
- Treatment with Dexmedetomidine
- Where
- France
- Sponsor
- University Hospital, Limoges
End Stage Cancer
Psychosocial Approach and Sedation Practices
This study aims to explore deeply the representations and emotional impact of MS on caregivers (doctors and nurses) and relatives of cancer patients.
- Trial name
- NCT04016038
- Testing
- a psycho-social investigation
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Palliative Sedation
Measuring Comfort During Palliative Sedation
Background. In case of untreatable suffering at the end of life, palliative sedation may be chosen to assure comfort by reducing the patient's level of consciousness.
- Trial name
- COMPAS (NCT03273244)
- Testing
- NeuroSense monitoring and ANI monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 12 people
- Sponsor
- Vrije Universiteit Brussel
Palliative Care, Deep Sedations
Prevalence of Deep Sedation in Terminal Palliative Phase
This nation-wide, multicentric, prospective and cross-sectional study aims to estimate the prevalence of deep sedations (i.e. with a -4 or -5 score at the Richmond scale at the induction time) for patients in terminal phase and…
- Trial name
- PREVAL-S2P (NCT04333719)
- Testing
- Type of sedations
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Bordeaux
Communication, Palliative Sedation
REcommened Communication With Sympathy in Terminally Ill Cancer Patients Treated With Palliative Sedation
In terminally ill cancer patients, palliative sedation has been applied to intractable refractory symptoms such as pain, dyspnea, delirium, agitation.
- Trial name
- RESTORE (NCT04642677)
- Testing
- healthcare provider's recommended communication with sympathy and printed paper
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Pusan National University Yangsan Hospital
Refractory Pains
Efficiency and Safety of a Procedural Sedation by Propofol on Terminally Ill Patients With Refractory Pain
Relieving symptoms of patients hospitalized in a palliative care unit is a priority. Although they receive appropriate care, they may still experience pain refractory to analgesia or/and to conservative treatment during care…
- Trial name
- PROPOPAL2 (NCT02734511)
- Testing
- sedation with propofol
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Palliative Care, Withdrawal of Life Support
End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made.
- Conditions
- Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation
- Trial name
- ARREVE-3 (NCT07368010)
- Testing
- Protocol for palliative care and life-support withdrawal
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Nantes University Hospital
Refractory Pains, End of Life Patients
Pilot Study of Sedation With Propofol in Refractory Pains Due to Care in Palliative Care Unit
In the palliative care unit, certain patients suffer from pain associated with medical procedures/care which is poorly controlled by antalgics.
- Trial name
- PROPOPAL1 (NCT02198404)
- Testing
- sedation with propofol
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Forearm Fracture, Radius Fractures
Pain Palliation in Forearm Fractures in the Emergency Department
The aim is to evaluate the success of reduction procedures and pain palliation in patients with forearm fractures undergoing reduction under procedural sedation-analgesia (PSA) and ultrasound (US)-guided infraclavicular nerve…
- Conditions
- Forearm Fracture, Radius Fractures, Ulnar Fracture
- Trial name
- NCT06588907
- Testing
- Bupivacaine Hydrochloride, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Ankara Etlik City Hospital
Pain Intractable, Delirium
Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients
Cancer patients with very difficult to control symptoms at the Abbotsford (AC) and Fraser Valley (FVC) Cancer Centers are referred and admitted to the Tertiary Palliative Care Units at the Abbotsford Regional Hospital and Cancer…
- Conditions
- Pain Intractable, Delirium, Dyspnea, Nausea
- Trial name
- NCT01687751
- Testing
- Dexmedetomidine, Midazolam
- Where
- Canada
- Sponsor
- Fraser Health
Palliative Sedation
The Clinical Practice of Palliative Sedation
Palliative Sedation (PS) is defined as the intentional lowering of consciousness of a patient in the last phase of life, to relieve patients suffering from refractory symptoms.
- Trial name
- PALLSED (NCT04719702)
- Where
- 8 sites in Belgium, Germany and 3 more
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center