Clinical trials: Pancreatic Resection
Pancreatic Masses
Diagnostic Prediction of Pancreatic Masses
The goal of this observational study is to learn if a strategy can be developed for differentiating autoimmune pancreatitis (AIP) and primary pancreatic lymphoma (PPL) from pancreatic ductal adenocarcinoma (PDAC) in patients…
- Trial name
- NCT06724055
- Volunteers
- 110 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Ductal Adenocarcinoma (PDAC)
OSCAR I STUDY - The ONCObind CTC Removal Study
This study is a Prospective Single Arm Open Label Feasibility trial to evaluate the initial safety and signal of efficacy of a novel extracorporeal blood purification (EBP) procedure in metastatic PDAC refractory to systemic…
- Trial name
- NCT06481397
- Testing
- ONCObind (Onco-Seraph) 100 Filter
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- ExThera Medical Corporation
Liver Cancer, Pancreatic Cancer
Postoperative Thoracic Epidural Analgesia Versus Intravenous Patient-Controlled Analgesia For Liver and/or Pancreas
The goal of this clinical research study is to learn if there is a difference in patients' quality of recovery if they receive 1 of 2 standard kinds of pain control treatments after surgery on the liver and/or pancreas.
- Trial name
- NCT01438476
- Testing
- Intravenous Patient-Controlled Analgesia (IVPCA), Thoracic Epidural Analgesia (TEA), Questionnaires
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Fistula, Distal Pancreatectomy Complications
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
The purpose of this trial is to determine whether the use of an autologous falciform ligament patch combined with fibrin glue will reduce the rate of pancreatic fistula in patients completing distal pancreatectomy.
- Conditions
- Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
- Trial name
- NCT00889213
- Testing
- Falciform patch and fibrin glue application, standard pancreatic closure
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pancreatic Cancer
Vaccine Treatment for Surgically Resected Pancreatic Cancer
This 2-phase study will determine the safety of treating patients with pancreatic cancer with the genetically engineered HyperAcute-Pancreatic cancer vaccine.
- Trial name
- NCT00255827
- Testing
- HyperAcute-Pancreatic Cancer Vaccine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- NewLink Genetics Corporation
Von Hippel-Lindau Disease
Natural History and Management of Pancreatic Lesions in Von Hippel-Lindau Disease
Von Hippel-Lindau disease (VHL) is an inherited cancer syndrome. Patients are at risk for developing pancreatic cysts and tumors. These tumors are more aggressive in some people than in others.
- Trial name
- NCT00062166
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- National Cancer Institute (NCI)
Cancer of Pancreas, Cancer of the Pancreas
Epidural Analgesia Use in Pancreatic Resections
The rationale for this study is to investigate the benefits of epidural analgesia in pancreatic resections in a prospective, single blind, randomized control trial.
- Conditions
- Cancer of Pancreas, Cancer of the Pancreas, Pancreas Cancer, Pancreas Neoplasms
- Trial name
- E-PRO I (NCT02681796)
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Washington University School of Medicine
Safety Issues
he Safety Research of Timing of the Removal of Abdominal Drains After Pancreatic Surgery
Randomized, open, single-center, controlled prospective studies were designed to obtain reliable level I evidence in evidence-based medicine.Based on the premise of at least a 6-fold reduction in pancreatic fistula, as observed…
- Trial name
- NCT04892615
- Testing
- drainage tube was removed on 5th days after surgery., drainage tube was removed on 7th days after surgery.
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Xian-Jun Yu
Pancreatic Adenocarcinoma
A Randomized Phase II/Genomic Trial of Two Chemotherapy Regimens in Patients With Resected Pancreatic Adenocarcinoma
Determine the relapse-free survival of resected pancreatic cancer patients following two novel regimens with activity in advanced disease.
- Trial name
- NCT01839799
- Testing
- Gemcitabine, Abraxane, FOLFIRINOX
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pancreatic Malignant Neoplasm Primary
Failure to Adjuvant Therapy After Pancreatic Resection for Pancreatic Cancer
This study aims to evaluate the rate of patients submitted to pancreatic resection for pancreatic cancer, who fail to access to adjuvant therapy or do not complete adjuvant therapy.
- Trial name
- FOUNTAIN (NCT03788382)
- Where
- Italy
- Volunteers
- 317 people
- Sponsor
- Universita di Verona
Pancreas Cancer
Outcomes of Surgical Resection of Pancreatic Cystic Neoplasms Based on the European Expert Consensus Statement: A Prospective Observational Study.
Introduction: Pancreatic cystic neoplasms (PCNs) comprise neoplasms with a wide range of benign and malignant varieties. The most common include serous cystic neoplasms (SCNs), mucinous cystic neoplasms (MCNs), intraductal…
- Trial name
- NCT04747600
- Testing
- surgical resection
- Volunteers
- 63 people
- Sponsor
- Zagazig University
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Controlled Trial Comparing Closed-suction Drain Versus Passive Gravity Drain Following Pancreatic Resection
Pancreatic resection is the only potentially curative modality of treatment for pancreatic neoplasm. The mortality associated with this procedure decreased rapidly in the past decades.
- Trial name
- DRAPA (NCT01988519)
- Testing
- Closed gravity drain, closed suction drain
- Where
- 2 sites in Czechia
- Volunteers
- 223 people
- Sponsor
- University Hospital Hradec Kralove
Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer
Mesopancreatic Excision for Pancreatic Duct Adenocarcinoma.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high rates of local recurrence and distant metastasis. Recent evidence suggests that mesopancreatic excision (TMpE) may improve R0 resection rates, reduce local…
- Trial name
- TMpE (NCT07148830)
- Testing
- Total Mesopancreas Excision (TMpE) (as part of Pancreaticoduodenectomy)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Exocrine Pancreatic Insufficiency (EPI)
A Study of Creon (Pancrelipase) in Resected and Non-resected Pancreatic Cancer Participants With Exocrine Pancreatic Insufficiency (EPI)
This is a study in participants with Exocrine Pancreatic Insufficiency (EPI) due to pancreatic cancer. This study will include resected participants who are post pancreatic cancer surgery, and an additional cohort in non-resected…
- Trial name
- NCT03859869
- Testing
- Pancrelipase
- Where
- 33 sites in United States
- Volunteers
- 1 people
- Sponsor
- AbbVie
Pancreatic Cancer
SBRT Plus Pembrolizumab and Trametinib for Pancreatic Cancer
Hypothesis: Survival benefits could be found in SBRT Plus Pembrolizumab and Trametinib compared with SBRT plus gemcitabine.
- Trial name
- NCT02704156
- Testing
- Cyberknife plus Pembrolizumab and Trametinib, Cyberknife plus Gemcitabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Changhai Hospital
Pancreatic Necrosis, Acute Pancreatitis
Necrosectomy With Cryotechnology for Accelerated Removal
Pancreatic necrosis is a serious complication of acute pancreatitis. Pancreatic necrosis involves the irreversible death of pancreatic tissue, which can lead to severe health issues, including infections and an increased risk of…
- Conditions
- Pancreatic Necrosis, Acute Pancreatitis, Acute Pancreatic Necrosis, Necrosis
- Trial name
- NECTAR (NCT06553651)
- Testing
- Cryotechnology Necrosectomy Procedure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Adenocarcinomas of the Pancreas
Study on Hyperthermic Intraperitoneal Chemotherapy After Resection of Pancreascarcinoma
In patients with peritoneal metastases of colorectal cancer could be a radical removal of all tumor foci a significantly improved survival compared to a sole systemic chemotherapy are additionally achieved by a hyperthermic…
- Trial name
- PanHIPEC (NCT02863471)
- Testing
- Gemcitabine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital Tuebingen
Pancreatic Cancer
Postoperative Proton Radiotherapy With Chemo for Pancreatic Cancer
The purpose of this study is to find out what effects, good and/or bad, proton radiation combined with chemotherapy has on resected pancreatic cancer.
- Trial name
- PC03 (NCT01553019)
- Testing
- Proton radiation, Gemcitabine
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Preoperative Physical Exercise Training, Aerobic Capacity
Home-based Prehabilitation in Pancreatic Resection
Rationale: The complication rate after pancreatic resection is high, especially in elderly and physically unfit patients. Aerobic capacity, as indicated by the ventilatory anaerobic threshold (VAT) assessed by a cardiopulmonary…
- Conditions
- Preoperative Physical Exercise Training, Aerobic Capacity, Aerobic Fitness, Functional Mobility
- Trial name
- NCT05496777
- Testing
- Home-based prehabilitation program
- Where
- 3 sites in Italy, Netherlands
- Volunteers
- 45 people
- Sponsor
- Nicole Hildebrand
Pancreas Neoplasms, Pancreatitis
PROMs After Pancreatectomy
The standard of care for a patient with resectable pancreatic is to perform pancreatic resection which, even in the modern era is associated with significant complications and impact on quality of life, often in the setting of…
- Conditions
- Pancreas Neoplasms, Pancreatitis, Pancreatic Cyst
- Trial name
- PERSPECTIVE (NCT07173257)
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Arizona