Clinical trials: Pancreatic Surgery, active
Pancreas Cancer, Diabetes
Structured Follow-up Intervention on Glucose Status After Pancreatic Cancer Surgery
The primary aim of the present study is to examine the effect of a "structured follow-up intervention" to be performed in the first three months after PD on blood glucose.
- Trial name
- FiGluR (NCT06774170)
- Testing
- structured follow-up intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dokuz Eylul University
Resectable Colorectal Carcinoma, Resectable Digestive System Carcinoma
Acupuncture for the Management of Postoperative Pain in Patients With Pancreatic or Colorectal Cancer Undergoing Surgery
This trial investigates how well acupuncture works for the management of pain after surgery in patients having open colorectal or pancreatic surgery. Acupuncture may help to reduce postoperative symptoms including pain.
- Conditions
- Resectable Colorectal Carcinoma, Resectable Digestive System Carcinoma, Resectable Pancreatic Carcinoma
- Trial name
- NCT04560712
- Testing
- Acupuncture Therapy, Best Practice, Questionnaire Administration
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer
Prediction of Surgical Resectability After FOLFIRINOX Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: the Role of Diffusion Weighted Magnetic Resonance Imaging, Radiomics and Liquid Biopsy (PeRFormanCe Trial)
In this prospective study, new diagnostic tools will be explored for patients with borderline resectable and locally advanced pancreatic ductal adenocarcinoma (BR or LAPDA) who undergo neoadjuvant chemotherapy with FOLFIRINOX.
- Trial name
- PeRFormanCe (NCT05298722)
- Testing
- Imaging analysis of CT-scan and MRI with radiomics and genetic analysis of peripheral blood samples and questionnaires.
- Where
- 8 sites in Belgium, Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Pancreatic Cancer, Surgery
Examining Safety, Efficacy and Feasibility of Preoperative Propranolol in Patients With PDAC.
The IMPULS trial is a randomized, triple-blinded, placebo controlled, single center, pilot trial examining the efficacy and safety of preoperative propranolol in patients scheduled for pancreatic cancer surgery.
- Trial name
- IMPULS (NCT06145074)
- Testing
- Propranolol
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Zealand University Hospital
Diabetes Mellitus, Pancreas Transplantation
The Norwegian Pancreas Transplantation (PTx) Study
Several studies have shown acceptable results after Pancreas Transplantation (PTx) by substituting ATG with basiliximab, which is considered to convey a considerably lower number of adverse events.
- Conditions
- Diabetes Mellitus, Pancreas Transplantation, Allograft Rejection, Surgical Complication Nec
- Trial name
- PTx (NCT01957696)
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Fibroadenoma, Breast Fibroadenoma
Management of Breast Fibroadenoma: Comparing Observation, Microwave Ablation, and Surgical Excision
The purpose of this study is to evaluate and compare three different management strategies for benign breast fibroadenoma: conservative management with clinical and radiological follow-up (observation), ultrasound-guided…
- Conditions
- Fibroadenoma, Breast Fibroadenoma, Benign Breast Disease
- Trial name
- NCT07890766
- Testing
- Ultrasound-guided percutaneous microwave ablation, Conventional open surgical excision
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic
Pancreatic Cyst
Blood and Cystic Fluid From Patients Undergoing Surgery for Worrisome Pancreatic Cysts
The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection.
- Trial name
- NCT07767227
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Translational Genomics Research Institute
Pancreatic Cancer Resectable
Conventional Partial Pancreatoduodenectomy Versus an Extended Pancreatoduodenectomy for Pancreatic Head Cancers
The goal of this clinical trial is to learn if traditional pancreaticoduodenectomy (PD) combined with TRIANGLE (extended PD surgery) can increase disease-free survival (DFS) in patients with pancreatic head cancers compared to…
- Trial name
- NCT06703905
- Testing
- Expanded pancreaticoduodenectomy surgery, Pancreaticoduodenectomy
- Volunteers
- 270 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pancreatic Ductal Adenocarcinoma (PDAC), Borderline Resectable Pancreatic Cancer
PDAC Regression and Intraoperative Surgical Margin With Neoadjuvant TAMP (PRISM-TAMP)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival outcomes, even when treated with modern chemotherapy and radiation.
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Borderline Resectable Pancreatic Cancer, Pancreatic Neoplasms
- Trial name
- PRISM-TAMP (NCT07477418)
- Testing
- Gemcitabine Delivered by Transarterial Microperfusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Vermont
Pancreas Adenocarcinoma, Resectable Pancreatic Cancer
Testing the Combination of Two Approved Chemotherapy Drugs and Radiation Prior to Surgery in Localized Pancreatic Cancer
The purpose of this phase 2 research study is to determine whether a combination of chemotherapy drugs plus radiation therapy, given before surgery in resectable pancreactic cancer, can help to increase the chances of surgeons…
- Trial name
- NCT03492671
- Testing
- Gemcitabine 1000 mg, nab-paclitaxel, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Loma Linda University
Prehabilitation, Pancreas Cancer
Preoperative Optimisation of Modifiable Risk Factors in Surgery of the Pancreas
The goal of this stepped-wedge randomized controlled trial is to investigate whether implementation of a best practice program for preoperative optimisation (prehabilitation program) with a focus on screening, assessment, and…
- Conditions
- Prehabilitation, Pancreas Cancer, Surgery, Postoperative Complications
- Trial name
- PROMISE-P (NCT05851534)
- Testing
- Preoperative optimisation program
- Where
- 13 sites in Netherlands
- Volunteers
- 2,575 people
- Sponsor
- Maastricht University Medical Center
Pancreatic Neuroendocrine Tumor
Pancreatic Neuroendocrine Tumour - Optimal Surgical Debulking or Not
Pancreatic neuroendocrine tumours (pan-NETs) are neoplasms arising from the endocrine cells of the pancreas. Although pan-NET are quite rare, the incidence is on the rise and together with other abdominal neuroendocrine tumours…
- Trial name
- PANTODON (NCT07273409)
- Testing
- Debulking surgery
- Where
- 4 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Uppsala University
Pancreatic Cancer, Adult, Prehabilitation
Prehab for Pancreatic Cancer Surgery
The goal of this clinical study is to test whether a structured prehabilitation program can be successfully used by adults with pancreatic cancer who are receiving chemotherapy before planned surgery.
- Trial name
- NCT07478185
- Testing
- Multimodal Prehabilitation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Massachusetts, Worcester
Gastrointestinal Neoplasms
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
This study will check how well a new medicine, Risvutatug rezetecan, (Ris-Rez, also known as GSK5764227) works, how safe it is and how the body handles it in participants all around the world with advanced inoperable or…
- Trial name
- NCT06885034
- Testing
- Risvutatug Rezetecan
- Where
- 85 sites in United States, Australia and 17 more
- Volunteers
- 346 people
- Sponsor
- GlaxoSmithKline
Pancreatic Cancer Patients Diagnosed With Locally Advanced or Metastatic Pancreatic Cancer Not Amenable to Curative Surgical Resection, Pancreatic Cancer Borderline
EGFR Targeted Photoimmunotherapy With ASP-1929 for Locally Advanced Pancreatic Cancer
This is an open label phase II study to determine the safety and preliminary efficacy of photoimmunotherapy (PIT) for patients with locally advanced and borderline resectable pancreatic cancer.
- Conditions
- Pancreatic Cancer Patients Diagnosed With Locally Advanced or Metastatic Pancreatic Cancer Not Amenable to Curative Surgical Resection, Pancreatic Cancer Borderline, Pancreatic Cancer Resectable
- Trial name
- NCT07698613
- Testing
- ASP-1929 photoimmunotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brown University
Whipple Operation
Dachengqi Decoction for Enhancing Early Gastrointestinal Recovery After Whipple Surgery
To investigate the clinical efficacy of the traditional Chinese medicine formula Dachengqi Decoction in promoting early gastrointestinal function recovery after Whipple surgery, and to evaluate its impact on postoperative…
- Trial name
- NCT06948474
- Testing
- Dachengqi decoction, modified gastrointestinal dual-lumen feeding tube, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 45 people
- Sponsor
- China-Japan Friendship Hospital
Borderline Resectable Pancreatic Ductal Adenocarcinoma
NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial
This phase II trial tests how well liposomal irinotecan, oxaliplatin, 5-fluorouracil and leucovorin (NALIRIFOX) before surgery works in treating patients with pancreatic ductal adenocarcinoma that is close to major blood vessels…
- Trial name
- NCT06821997
- Testing
- Biospecimen Collection, Computed Tomography, Fluorouracil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Pancreatic Cancer, Pancreatic Neoplasms
Wearable-Supported Prehabilitation and Rehabilitation for Patients Undergoing Surgery for Pancreatic Cancer
The goal of this clinical trial is to evaluate whether a wearable-enabled prehabilitation and rehabilitation pathway can improve recovery and post-operative outcomes in adults undergoing surgery for pancreatic cancer or related…
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Periampullary Carcinoma, Pancreatic Surgery
- Trial name
- POWR-PaC (NCT07772258)
- Testing
- Corsano CardioWatch, Prehab4Cancer Programme
- Volunteers
- 120 people
- Sponsor
- Manchester University NHS Foundation Trust
Pancreatic Cancer
PANCREATIC DISEASE COHORT A Registry and Biospecimen Bank to Better Understand Pancreatic Disease
The specific aims of this project are to create a registry, as well as a biospecimen bank for individuals with pancreatic disease (e.g.
- Trial name
- NCT01102556
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University