Clinical trials: Paracervical Block
Pain
Buffered Lidocaine in Paracervical Blocks
For pain relief during a first trimester surgical aspiration, most providers use the paracervical block, either alone or in combination with other pain control techniques.
- Trial name
- NCT03107754
- Testing
- Lidocaine, Lidocaine-Sodium Bicarbonate
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Contraception
The PRICE Trial: Pain Reduction for Intrauterine Contraception Experiment
Intrauterine devices (IUDs) are a highly effective form of reversible contraception with a less than 1% failure rate. They can be easily placed in the office and require little maintenance care.
- Trial name
- PRICE (NCT06532162)
- Testing
- 1% Lidocaine Paracervical Block, Normal Saline Paracervical Injection
- Where
- Canada
- Volunteers
- 246 people
- Sponsor
- Mount Sinai Hospital, Canada
Contraception, Pain, Acute
Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed.
- Conditions
- Contraception, Pain, Acute, Anesthesia, Local
- Trial name
- EPIC (NCT06960317)
- Testing
- Buffered Lidocaine, Unbuffered lidocaine, Xylocaine jelly 2%
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Legal Abortion With Complication, Pain
Paracervical Block for Pain Control in First Trimester Abortion
Many woman undergoing a surgical abortion receive a paracervical nerve block for pain reduction, in which lidocaine (a numbing medication) is injected around the cervix.
- Trial name
- NCT01094366
- Testing
- Paracervical Block
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pain
12 Versus 20 mL PCB for D&E Cervical Prep
More research is needed to investigate methods of pain control for cervical preparation for abortion procedures. Women report pain with paracervical block injection as well as with osmotic dilator placement.
- Trial name
- NCT03356145
- Testing
- 12 mL paracervical block, 20 mL paracervical block
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pain, Postoperative
Preemptive Local Anesthesia in Vaginal Surgery
Preemptive analgesia is an intervention which provides an anesthetic prior to initiating a painful stimulus. This trial is examining the effects of a local anesthetic given at the point of innervation prior to performing a…
- Trial name
- NCT00318292
- Testing
- bupivacaine and epinephrine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Pelvic Organ Prolapse (POP), Postoperative Pain
Effect of Paracervical Block on Postoperative Pain After vNOTES Uterosacral Ligament Suspension
This study is a prospective, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effect of paracervical block on early postoperative pain after vaginal natural orifice transluminal endoscopic…
- Trial name
- vNOTES-PB (NCT07440576)
- Testing
- Bupivacaine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Erkan Gol
Paracervical Block
Paracervical Block During Office Hysteroscopy
The purpose of this study is to determine the effectiveness of paracervical block for pain relief in office hysteroscopy - particularly with the placement of the Essure device.
- Trial name
- NCT00811187
- Testing
- Lidocaine paracervical block, Normal Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain Management, Abortion
Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement
The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.
- Conditions
- Pain Management, Abortion, Second Trimester Abortion, Dilation and Evacuation
- Trial name
- PCB-KinD (NCT07487246)
- Testing
- Ketorolac, oral ibuprofen, Lidocaine HCl 1%
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Rush University Medical Center
Surgical Abortion
Cervical Preparation of Abortions Under Paracervical Block in the First Trimester:
Surgical abortion is one of the most frequently surgery of women in the world. 43 millions are annually performed in the world. 90% of the abortions are performed during the first trimester of pregnancy before 13 weeks.
- Trial name
- BPCEN (NCT03043014)
- Testing
- Mifépristone versus Misoprostol
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pain Due to Intrauterine Contraceptive Device
Pain Control for Intrauterine Device Placement Using Paracervical Block
Intrauterine device (IUD) placement can be painful for patients during and after the procedure. Fear of pain from IUD insertion can be a barrier to obtaining this highly effective long acting reversible contraception.
- Trial name
- NCT02219308
- Testing
- Paracervical Block (PCB)
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Pipelle Versus Karman Endometrial Biopsy Under Standardized Paracervical Block
Endometrial biopsy is a commonly used outpatient procedure to evaluate abnormal uterine bleeding and postmenopausal bleeding. Different sampling methods are available, but their diagnostic adequacy and patient experience may…
- Trial name
- PB-EMB (NCT07366814)
- Testing
- Pipelle Endometrial Biopsy, Karman Cannula Endometrial Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 480 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pain During Saline Infusion Sonogram
Paracervical Block for Pain Reduction in Saline Infusion Sonograms
Inadequate pain management during gynecologic procedures is a growing women's health concern, especially as it reduces access to care for patients who may subsequently avoid further treatment.
- Trial name
- NCT07048769
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Montefiore Medical Center
Uterine Curettage, Abortion, Induced
Evaluation of Different Anesthesia for Uterine Curettage
Anesthesia during uterine curettage is a problem. Paracervical block is used in general for such an operation, though, the anesthetic efficacy is incomplete.
- Trial name
- EDAUC (NCT00733564)
- Testing
- Lidocaine, Propofol, Sevoflurane
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanjing Medical University
Second Trimester Medical Abortion
Paracervical Block During II-trimester Abortion
Paracervical blockage can reduce severe pain during second trimester induced medical abortion.
- Trial name
- NCT01617564
- Testing
- bipuvacain, NaCl
- Where
- 2 sites in Sweden
- Volunteers
- 112 people
- Sponsor
- Kristina Gemzell Danielsson
Pain
Lidocaine-Prilocaine Cream in Conjunction With Paracervical Block for Pain With Abortion
The investigators theorize that the application of a lidocaine-prilocaine cream 5-10 minutes prior to the administration of a paracervical block could decrease pain associated with its administration and pain with abortion…
- Trial name
- NCT03508804
- Testing
- Lidocaine-Prilocaine Cream, 1% Lidocaine Paracervical Block
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Hysterosalpingography-Related Pain
Pain Control During Hysterosalpingography: A Three-Arm Randomized Trial
Hysterosalpingography (HSG) is commonly performed during infertility evaluation and may cause pain during cervical manipulation, uterine distension, and contrast-medium injection.
- Trial name
- HSG-PAIN (NCT07792668)
- Testing
- Indomethacin 100Mg Suppository, Lidocaine %2 ampoule
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Abnormal Uterine Bleeding, Analgesia
Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy
A randomized double-blind placebo controlled trial comparing the effect of a combined ketorolac and lidocaine paracervical block with a standard lidocaine paracervical block on procedure related pain with office hysteroscopies.
- Conditions
- Abnormal Uterine Bleeding, Analgesia, Paracervical Block
- Trial name
- NCT06653400
- Testing
- paracervical block, Lidocaine, ketorolac
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myoma;Uterus, Polyp Uterus
Paracervical Block Versus Transcervical Block in Outpatient Procedural Hysteroscopy
Hysteroscopy is a minimally invasive, diagnostic and therapeutic gynecological surgical technique and the gold standard in the study of the uterine cavity.
- Trial name
- NCT05967936
- Testing
- Bupivacaine Injection
- Where
- Canada
- Volunteers
- 242 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal