Clinical trials: Paracetamol Administration
Healthy
A Relative Bioavailability Study of Acetaminophen 650 mg Extended Release Gelcaps Under Fed Condition
The study was conducted as an open label, balanced, randomised, two-treatment, two-period, two-sequence, single dose, crossover bioavailability study comparing acetaminophen extended release gelcaps 650 mg (containing…
- Trial name
- NCT01079078
- Testing
- Acetaminophen
- Where
- India
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Pain
Paracetamol / Ibuprofen for Postpartum Pain in the Early Postpartum Period
The investigators will examine the effectiveness of non-opioid analgesia (Paracetamol versus Ibuprofen) in the early postpartum period
- Trial name
- NCT04653506
- Testing
- Paracetamol 1000 mg, Ibuprofen 400 mg
- Where
- Israel
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Focus of Study: Pharmacokinetics Analysis, in Vivo Dissolution Studies
Pharmacokinetics of a Standard Paracetamol Tablet and Oral Solution After Oral Administration in Chinese Healthy Volunteers
Drug dissolution in vivo play a crucial role for the bioavailability and therapeutic of an orally administered solid dosage form.
- Trial name
- NCT02095704
- Testing
- paracetamol oral solution, paracetamol tablet
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Central South University
Obesity, Morbid
The Effect of Timing of Intravenous Paracetamol Administration on Post-surgical Pain
This study is designed as a population-based prospective randomized cohort study. A prospective cohort of patients admitted to laparoscopic sleeve gastrectomy due to morbid obesity
- Trial name
- NCT03221998
- Testing
- IV paracetamol, IV saline (NaCl 0.9 %)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Pain
To Evaluate the Paediatric Analgesia Slide
The Paediatric Analgesia Slide is a device developed for parents. Its development follows research into the Paediatric Analgesia Wheel, a device intended for use by hospital doctors.
- Trial name
- NCT00765609
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- County Durham and Darlington NHS Foundation Trust
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pain, Postoperative Pain
Efficacy of Different Drugs to Control Post Root Canal Treatment Pain
Root canal therapy will ideally eliminate post-endodontic pain but occasionally analgesics are needed to diminish the pain [Owatz et al 2007].
- Conditions
- Pain, Postoperative Pain, Irreversible Pulpitis
- Trial name
- NSAID (NCT02417337)
- Testing
- Paracetamol, Ibuprofen, Mefenamic Acid
- Where
- Sudan
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Khartoum
Healthy
A Relative Bioavailability Study of Acetaminophen Extended Release Gel Tabs 650 mg Under Fasting Condition
The study was to compare single-dose oral bioavailability of acetaminophen 650 mg extended release geltabs (containing acetaminophen 650 mg) of OHM Laboratories Inc.
- Trial name
- NCT01523080
- Testing
- Acetaminophen
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Pain, Orofacial
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management
The purpose of this study is to compare the effectiveness of a combined ibuprofen and acetaminophen regimen in controlling discomfort for 4 days after initial orthodontic appliance placement as compared to ibuprofen alone or a…
- Trial name
- NCT04059172
- Testing
- Ibuprofen 200 mg and acetaminphen 650 mg, Ibuprofen 200 mg
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pain, Acute
Acetaminophen IV vs Hydromorphone IV in the ED
The purpose of the current study is to compare the analgesic efficacy of intravenous acetaminophen and intravenous hydromorphone in the treatment of acute pain in the ED.
- Trial name
- NCT03107481
- Testing
- Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Multimodal Analgesic Approach
IV vs Oral Acetaminophen in Spine Fusion Perioperative Care
The United States is currently experiencing an explosive opioid epidemic. In 2014 alone, 28,647 Americans died from an opioid associated overdose; the annual death toll has increased by over 300% since 2000.
- Trial name
- NCT03020875
- Testing
- Ofirmev, Per Os Acetaminophen
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Enteral Nutrition
Gastric Emptying Study After Administration of a High Caloric Sip Feed
Measurement of gastric emptying time of an oral nutritional supplement (ProvideXtra DRINK) by using the paracetamol absorption method in healthy volunteers.
- Trial name
- NCT00600678
- Testing
- ProvideXtra DRINK (oral nutritional supplement, food for special medical purposes)
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fresenius Kabi
Healthy
A Relative Bioavailability Study of Acetaminophen 650 mg Extended Release Gelcaps Under Fasting Condition
The study was conducted as an open labeled, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioavailability study comparing acetaminophen extended release gelcaps 650 mg of OHM Laboratories…
- Trial name
- NCT01073709
- Testing
- Acetaminophen
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Caesarean Section; Pain
Parecoxib vs. Dexketoprofen for the Management of Pain After Cesarean Section.
Although it is known that parecoxib and dexketoprofen are commonly used in successful post-operative pain relief, there are very few studies that compare these two agents in their individual applications and/or combined with…
- Trial name
- NCT04847024
- Testing
- Parecoxib, Dexketoprofen
- Where
- Panama
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Saint Thomas Hospital, Panama
Pain
Comparative Bioavailability Study of Codeine Sulfate
The objective of this study was to assess the comparative bioavailability of codeine from Roxane Laboratories' Codeine Sulfate 30mg tablets to Tylenol® #3 (acetaminophen 300mg with codeine phosphate 30mg) under fasted conditions
- Trial name
- NCT01010152
- Testing
- Codeine Sulfate
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
NSAID, Pain Management
Pre-emptive Analgesics in Orthodontic Treatment
This study is designed to determine if the preemptive use of a combination of acetaminophen and ibuprofen is more effective in reducing pain following orthodontic tooth movement when compared to the use of acetaminophen and…
- Trial name
- NCT03523988
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pain Management, Cesarean Section
To Compare the Efficacy and Patient's Satisfaction From Pain Management of Women After Cesarean Section by Pain Relievers' Administration in Fix Protocol Compared to Protocol Following Demand
Cesarean deliveries are prevalent. Unlike other operations, quick recovery is required for the mother to nurture the newborn child and establishing an appropriate mother-child bonding.
- Trial name
- NCT01764048
- Testing
- Fix protocol, medications following demand protocol
- Where
- Israel
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Pain
An Effectiveness and Safety Study Comparing Acetaminophen (3900 mg/Day) to Ibuprofen (1200 mg/Day) in the Treatment of Post-Race Muscle Soreness.
The purpose of this study is to compare the effectiveness and safety of acetaminophen extended release caplets and ibuprofen in relieving the muscle soreness that occurs after a marathon.
- Trial name
- NCT00240838
- Testing
- acetaminophen extended release caplets
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Gastrointestinal Motility Disorder
Absorption of Paracetamol, Talinolol and Amoxicillin After Oral Administration Using Non-caloric and Caloric Water
To visualize the localization and to measure the volume of water in the small intestine by T2-weighted MRI imaging after oral administration of 240 ml water (non-caloric water) and after administration of 240 ml water containing…
- Trial name
- NCT01635608
- Testing
- Acetaminophen, Talinolol, Amoxicillin
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Obesity
Morphine-sparing Effect of Intravenous Paracetamol for Post-operative Pain Management Following Laparoscopic Gastric Banding in Morbidly Obese Patients
The investigators predict that giving patients paracetamol in the operative period will reduce their need for opioid pain reducers in the post operative setting.
- Trial name
- NCT02154464
- Testing
- Paracetamol
- Where
- Israel
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center