Clinical trials: Paralysis
Cortical/Cerebral Visual Impairment, Cerebral Palsy
Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment
The goal of this study is to learn about eye gaze technology's use as an assessment and intervention of visual skills and the impact on occupational performance in children with cortical/cerebral visual impairment.
- Trial name
- NCT06067607
- Testing
- eye gaze technology
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockhurst University
Functional Dyspepsia
Assessment of GI Function to a Large Test Meal by Non-invasive Imaging
Dyspeptic symptoms such as abdominal pain, bloating and nausea after a meal are common; however the cause of these problems in many patients is often unclear despite medical investigation.
- Trial name
- NCT03007433
- Testing
- 400ml of Liquid Nutrient Drink
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Parkinson Disease
Quantification Tools for a Novel Tau PET Marker in a Rare Neurological Disease: 18F-PI-2620 in Progressive Supranuclear Palsy
The aim of this clinical trial is to explore the potential of novel 2nd generation tau PET radiotracers as biomarkers in cases suggestive of progressive supranuclear palsy (PSP), an atypical form of parkinsonism.
- Trial name
- Quanti-TAU-PET (NCT07105384)
- Testing
- Radiotracer
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Cerebral Palsy
Robot-assisted Training in Children With CP
Cerebral palsy (CP) is the most common physical disability in early childhood causing serious motor and sensory impairments. Effective interventions for the recovery of motor functions are of profound significance to children…
- Trial name
- NCT06450158
- Testing
- Robot (Amadeo)-assisted Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Cerebral Stroke, Hemiplegia, Spastic
Compensatory Kinematic Movements in Various Directions After Stroke
This is cross-sectional study. By comparing kinematic analysis between stroke and healthy subjects in various directions, this investigation analyzes the compensatory kinematic movement for reaching task in stroke survivors
- Trial name
- NCT05683158
- Where
- South Korea
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Tetraplegia, Asthma
Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury
The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers.
- Trial name
- NCT02235714
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Facial Paralysis
Myofunctional Therapy in Facial Palsy
Objective: Quantify the benefits of myofunctional therapy associated to botulinum toxin injection in patients with long standing facial unilateral palsy.
- Trial name
- NCT00989209
- Testing
- Botulinum Toxin Type A, myofunctional therapy
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Gastroparesis
Needs Assessment Evaluating Quality of Life Issues for Gastroparesis Patients and Caregivers
The project will involve conducting a Needs Assessment for Gastroparesis patients and their caregivers with the goal of identifying quality of life issues associated with this disease.
- Trial name
- NCT01329211
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cerebral Palsy
Fall Frequency in Children With Cerebral Palsy
The aim of this cross-sectional clinical study is to evaluate the frequency of falls in children diagnosed with cerebral palsy and compare it with healthy controls.
- Trial name
- NCT06679166
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Beylikduzu State Hospital
Unilateral Cerebral Palsy
Validation of AI for Personalized Assessment and Rehabilitation of Upper Limb in Children With Unilateral Cerebral Palsy
Unilateral Cerebral palsy (UCP) is the most common neurological chronic disease in childhood with a significant burden on children, their families and health care system.
- Trial name
- AInCP (NCT06073522)
- Testing
- Artificial Intelligence for combining multi-domain data acquisition
- Where
- 2 sites in Italy, Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies
A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
This will be a double blind, randomised, placebo controlled, single and multiple oral dose study conducted in 3 parts: Part A, Part B and Part C.
- Conditions
- Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies, MELAS Syndrome, Mitochondrial Myopathies
- Trial name
- NCT03888716
- Testing
- KL1333
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abliva AB
Spinal Cord Injury
Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation
The purpose of this study is to investigate whether combining a noninvasive method of brain stimulation, called Transcranial Direct Current Stimulation (tDCS), enhances the effect of training of the affected upper limbs in…
- Trial name
- NCT01539109
- Testing
- Rehabilitation, Noninvasive brain stimulation: tDCS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Healthy Volunteers, Spinal Cord Injury
Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis
This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves…
- Conditions
- Healthy Volunteers, Spinal Cord Injury, Stroke, Paralysis
- Trial name
- NCT04755699
- Testing
- Transcutaneous Electrical Stimulation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cerebral Palsy
Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities
This study is investigating the potential effects of a high-intensity home-exercise program among children with cerebral palsy. The program includes rhythmic movements to music that are adapted for wheelchair uses and…
- Trial name
- NCT05619211
- Testing
- Sprint-Intensity Interval Training with Telecoaching
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gastroparesis
FTIH to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Oral Doses of GSK1322888 in Healthy Caucasian and Japanese Volunteers
This study is the First Time In Human study for the motilin receptor agonist, GSK1322888. GSK1322888 is a potent and selective small molecule motilin receptor agonist, distinct from the motilide compound structures.
- Trial name
- NCT01294566
- Testing
- GSK1322888
- Where
- Australia
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cerebral Palsy
Effects of Augmentative and Alternative Communication in Children With Cerebral Palsy Cerebral Palsy
Cerebral Palsy is a neuromuscular disorder that causes multiple disabilities in an individual. Children's ability to rely on speech as a primary mode of communication can be compromised by cerebral palsy.
- Trial name
- NCT06196944
- Testing
- Augmentative Alternative Communication, Augmentative Alternative Communication Device
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pain, Acute, Vocal Fold Polyp
Patient Augmented Reality and Vibratory Array Otorhinolaryngology Procedures
In-office procedures (IOPs) are a cost-effective, and safe alternative to many operating room procedure, with benefits such as reduced anesthesia risk.
- Conditions
- Pain, Acute, Vocal Fold Polyp, Vocal Cord Paralysis, Laryngeal Neoplasms
- Trial name
- PARVA (NCT06227039)
- Testing
- Vibroacoustic stimulation on, Augmented Reality on, Vibroacoustic stimulation off
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hereditary Spastic Paraplegia, SPG47
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia
The Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia (HSP) is focused on gathering longitudinal clinical data as well as biological samples (skin and/or blood and/or saliva) from male and female…
- Conditions
- Hereditary Spastic Paraplegia, SPG47, SPG50, SPG51
- Trial name
- HSP (NCT04712812)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Neonatal Brachial Plexus Palsy
Forced Lefthandedness in Neonatal Brachial Plexus Palsy (NBPP) Children
The aim of the project is to assess the neurophysiological and functional consequences of forced lefthandedness in a population with right neonatal brachial plexus palsy (NBPP).
- Trial name
- NBPP (NCT04376372)
- Testing
- Functional testing, Magnetic resonance imaging, Electromyography
- Where
- Belgium
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Poststroke/CVA Hemiparesis, Paralytic Stroke
BCI Post-stroke Neurorehabilitation
The goal is to evaluate the potential of a EEG based BCI (Brain-Computer-Interface) connected to a non-invasive pneumatic glove for rehabilitation of hand-movements post-stroke.
- Conditions
- Poststroke/CVA Hemiparesis, Paralytic Stroke, Hand Flaccid Paralysis
- Trial name
- BCI-stroke (NCT02404857)
- Testing
- EEG based Brain Computer Interface
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier