Clinical trials: Parkinson's Disease
Idiopathic Parkinson's Disease (PD)
Study on the Incidence of Malignant Neoplasms in Patients With Parkinson's Disease and Heterozygous Mutation of the GBA Gene
This multicenter retrospective observational study investigates the incidence of malignant neoplasms in Parkinson's disease (PD) patients carrying heterozygous pathogenic variants in the GBA1 gene.
- Trial name
- ONCOGBA (NCT06814431)
- Where
- 4 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Parkinson Disease (PD), Immersive Virtual Reality
Virtual Reality on Balance of Parkinson's Disease
This study, titled: Effectiveness of immersive virtual reality on balance in people with Parkinson's disease. Is a randomized clinical trial conducted at Zaragoza Parkinson's Association in Spain.
- Conditions
- Parkinson Disease (PD), Immersive Virtual Reality, Physical Therapy
- Trial name
- RVI-PD (NCT07274514)
- Testing
- Immersive Virtual Reality Program, Standard Rehabilitation Program
- Where
- Spain
- Volunteers
- 57 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS)
Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders
Neurodegenerative disorders (NDDs), such as Parkinson¿s disease (PD), Alzheimer¿s disease (AD), Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are characterized by aggregation and intracellular accumulation…
- Conditions
- Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Alzheimer's Disease (AD)
- Trial name
- NCT06803784
- Testing
- Genetic: whole genome sequencing, whole exome sequencing
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Parkinson's Disease
The Relationship Between Homocysteine and Manifestation of Parkinson's Disease Patients
The aim of the current study is to investigate the association between blood homocysteine level and motor as well as cognitive manifestation of PD patients in Assiut governorate.
- Trial name
- NCT06849414
- Volunteers
- 44 people
- Sponsor
- Assiut University
Parkinson's Disease (PD), Deep Brain Stimulation
The Relation Between the Prognosis of Subthalamic Nucleus Deep Brain Stimulation Surgery by Microlesion Effect and Electrode Position
BACKGROUND: Parkinson's disease (PD) is a common movement disorder whose main symptoms include resting tremor, rigidity and bradykinesia.
- Trial name
- Microlesion Ef (NCT06685510)
- Testing
- the score of UPDRS item
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Parkinson Disease, MSA - Multiple System Atrophy
Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease
Clinical diagnosis of Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) is challenging, especially in the early stages.
- Conditions
- Parkinson Disease, MSA - Multiple System Atrophy, Lewy Body Dementia (LBD), Neurodegenerative Disease
- Trial name
- EXTRAORDINARY (NCT06846658)
- Where
- 3 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Parkinson's Disease (PD), Bradykinesia
Clinical Trail of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Upper Limb Bradykinesia in Parkinson' Disease' Patients
A randomized, double-blind, sham-controlled unicenter clinical trial was used to investigate the effectiveness and neural mechanism of high-frequency repetitive transcranial magnetic stimulation in the treatment of upper limb…
- Conditions
- Parkinson's Disease (PD), Bradykinesia, Upper Limb Function
- Trial name
- NCT06641193
- Testing
- high frequency-repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Parkinson's Disease (PD)
CuePD: Investigating the Effect of Personalised Auditory Cueing on Gait in Parkinson's Disease
Parkinson's Disease (PD) is a major cause of disability, globally. PD affects a person's movement speed, fluency, quality, and ease of walking.
- Trial name
- CuePD (NCT06941779)
- Testing
- Cueing
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Northumbria University
Parkinson's Disease (PD), Dual-task
The Effects of Dual Task Training With Different Task Priorities on Physical Performance and Cognitive Status in Patients With Parkinson's Disease
This study was planned to investigate and compare the effects of variable and fixed priority dual task training on balance, walking skills, mobility and cognition in patients with Parkinson's disease.
- Conditions
- Parkinson's Disease (PD), Dual-task, Balance, Walking
- Trial name
- NCT06794177
- Testing
- Variable priority dual task training, Fixed priority dual task training, Single task training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Parkinson's Disease (PD)
Low-Fidelity Driving Simulator Training in Parkinson's Disease.
The goal of this clinical trial is to learn if low-fidelity driving simulator training works to improve cognitive performance, driving behavior, and driving aptitude in individuals with Parkinson's disease.
- Trial name
- NCT07463755
- Testing
- Low-fidelity driving simulator training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Kansas Medical Center
Parkinson's Disease
fMRI-guided Transcranial Magnetic Stimulation Treatment for Parkinson's Disease
The goal of this clinical trial is to compare the efficacy of targeting the newly discovered SCAN versus traditional effector-specific networks in M1 using multimodal imaging and rTMS in patients with Parkinson's disease.
- Trial name
- NCT06734676
- Testing
- Intermittent theta burst stimulation (iTBS)
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Changping Laboratory
Deep Brain Stimulation, Parkinson's Disease
EEG Measurements to Capture DBS-induced Electric Potentials
To measure the electric fields induced by DBS (deep brain stimulation) on the scalp and to improve electric field simulations, the investigators will measure EEG (electroencephalography) measurements with high sampling rates…
- Trial name
- NCT07115394
- Testing
- EEG recording
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Bradykinesia, Parkinson Disease
prTMS as an Intervention for Bradykinesia in Parkinson's Disease
This study investigates the use of patterned repetitive transcranial magnetic stimulation (prTMS) as an intervention for bradykinesia in Parkinson's Disease (PD).
- Trial name
- ADAPT-BK (NCT07397377)
- Testing
- Active patterned repetitive transcranial magnetic stimulation (prTMS)
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Parkinson's Disease
Evaluation of GM101 Injection in Patients With Parkinson's Disease
The objective of this study is to assess the safety of GM101 in participants with Parkinson's disease (PD)
- Trial name
- NCT07100171
- Testing
- Biological: GM101
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Genemagic Biosciences Co., Ltd
Essential Tremor, Parkinson's Disease (PD)
Attention and Eye Movement in Parkinson's Disease
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement…
- Conditions
- Essential Tremor, Parkinson's Disease (PD), Dystonias
- Trial name
- NCT06899022
- Testing
- Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Parkinson's Disease, Parkinson
Impact of Ketoflex 12/3 Diet on Parkinson's Disease Symptoms: A Clinical Study
This study aims to investigate the effects of the Ketoflex 12/3 diet on motor and non-motor symptoms in patients with Parkinson's disease.
- Trial name
- NCT06892418
- Testing
- Ketoflex 12/3 Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Medipol University Hospital
Parkinson's Disease (PD)
PET-MRI of Reward System in Parkinson's Disease With RBD
Impulse control disorders (ICDs) are frequently observed in Parkinson's disease (PD) and can have a major functional impact on the quality of life of both the patient and their entourage.
- Trial name
- RBD Impulse (NCT07213219)
- Testing
- PET-MRI (Positron Emission Tomography - Magnetic Resonance Imaging).
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson&Amp;#39;s Disease, Action Tremor
Effectiveness of STIL Orthosis in PD
Parkinson's disease is a neurodegenerative condition that leads to uncontrollable shaking (tremor), which can substantially impair everyday activities.
- Trial name
- STIL-PD (NCT06886178)
- Testing
- STIL Orthosis
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Dysarthria, Hypokinetic
Listener Training for Improved Intelligibility of People With Parkinson's Disease
Listener training offers a promising avenue for improving communication for people with dysarthria due to Parkinson's disease by offsetting the intelligibility burden from the patient onto their primary communication partners.
- Trial name
- NCT06815263
- Testing
- Listener Training
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Utah State University
Adjustment Disorder
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to…
- Trial name
- NCT07002034
- Testing
- RE104 for Injection
- Where
- 32 sites in United States
- Volunteers
- 100 people
- Sponsor
- Reunion Neuroscience Inc