Clinical trials: Parkinson's Disease Patients
Parkinson Disease, Parkinson's Disease
A Long-Term Follow-up Study of the Severe Parkinson's Disease Patients Administered the IPS101A Gene Therapy Product.
The purpose of this study is to evaluate the long-term safety of IPS101A and to assess the durability of efficacy in subjects who received IPS101A.
- Trial name
- NCT07629115
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Innopeutics Corporation
Parkinson Disease
A 12-week Study of Pramipexole Extended Release (ER) in Patients With Parkinson's Disease (PD), Followed by a 52-week Long-term Treatment Period
The objective of this trial is to investigate the safety, tolerability, trough plasma concentration, and efficacy of pramipexole ER in comparison with those of pramipexole IR administrated orally for 12 weeks in patients with PD…
- Trial name
- NCT00560508
- Testing
- Pramipexole Immediate Release, Pramipexole Extended Release
- Where
- 19 sites in Japan
- Volunteers
- 112 people
- Sponsor
- Boehringer Ingelheim
Parkinson´s Disease
Clinical Trial of Rasagiline in Levodopa-Treated Parkinson's Disease Patients With Motor Fluctuations
The objective of this study is to evaluate the efficacy, tolerability, and safety of rasagiline compared to placebo in PD patients with motor fluctuations on levodopa therapy.
- Trial name
- NCT01736891
- Testing
- Rasagiline
- Where
- 8 sites in China
- Volunteers
- 268 people
- Sponsor
- Chongqing Fortune Pharmaceutical Co., Ltd.
Parkinson Disease
Safety and Efficacy Study of CEP-1347 in the Treatment of Parkinson's Disease
The purpose of this study is to establish safety for CEP-1347 and to determine an efficacious dose in the treatment of Parkinson's disease.
- Trial name
- NCT00040404
- Testing
- CEP-1347 10mg, CEP1347 25mg, CEP-1347 50mg
- Where
- 66 sites in United States, Canada and 1 more
- Volunteers
- 806 people
- Sponsor
- Cephalon
Parkinson's Disease With End of Dose Wearing Off
Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease
To assess motor function and quality of life (QoL) in Parkinson's disease (PD) subjects with end-of-dose wearing off, comparing immediate and delayed switch to carbidopa/levodopa and entacapone.
- Trial name
- NCT00219284
- Testing
- Carbidopa/levodopa/entacapone
- Where
- 42 sites in United States, Puerto Rico
- Volunteers
- 359 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease
Phase II Clinical Study of TR-012001 in Japanese Patients With Parkinson's Disease
The purpose of this study to evaluate the safety and pharmacokinetics of TR-012001 in patients with Parkinson's disease when TR-012001 or placebo is administered.
- Trial name
- NCT06212089
- Testing
- TR-012001
- Where
- Japan
- Volunteers
- 12 people
- Sponsor
- SNLD, Ltd.
Parkinson Disease
Safety and Efficacy of Long-term Daily Use of Mirapex®-LA Tablets in Patients With Parkinson's Disease
Post-marketing surveillance (PMS) to investigate the safety and efficacy of long-term daily use of Mirapex®-LA Tablets in patients with Parkinson's disease.
- Trial name
- NCT01525641
- Testing
- Mirapex LA
- Where
- 118 sites in Japan
- Volunteers
- 615 people
- Sponsor
- Boehringer Ingelheim
Parkinson's Disease, Major Depressive Disorder
Antidepressant Effect of Deep Brain Stimulation in Parkinson's Disease Patients
The purpose of this study is: 1. To determine, in the context of a prospective clinical trial, whether stimulation parameters in PD patients treated with DBS, are associated with antidepressant effects. 2.
- Trial name
- NCT00885222
- Testing
- DBS parameters setting
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Parkinson Disease
Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease
The purpose of the study is to demonstrate that continuous apomorphine treatment during the night compared with placebo improves sleep quality in insomniac patient with Parkinson's disease.
- Trial name
- APOMORPHEE (NCT02940912)
- Testing
- Apomorphine
- Where
- 9 sites in France
- Volunteers
- 45 people
- Sponsor
- Clinique Beau Soleil
Parkinson's Disease, Mild Cognitive Impairment
Deep Brain Stimulation of the nbM to Treat Mild Cognitive Impairment in Parkinson's Disease
The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation of the nucleus basalis of Meynert (also called the "nbM") at improving memory in Parkinson's disease patients with mild cognitive…
- Trial name
- NCT02924194
- Testing
- stimulation ON, stimulation OFF
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Parkinson Disease
Study Of Cabaser and Sinemet CR For The Treatment Of Nighttime Symptoms Associated With Parkinson's Disease.
The study will assess the relative benefit of cabergoline vs carbidopa/levodopa therapy in treating nighttime problems of Parkinson Disease.
- Trial name
- NCT00174239
- Testing
- cabergoline, controlled-release levodopa / carbidopa
- Where
- 14 sites in Australia, Italy and 1 more
- Volunteers
- 220 people
- Sponsor
- Pfizer
Parkinson Disease, Fatigue
Lifestyle and Non-motor Symptom Management in Parkinson's Disease
Parkinson's Disease (PD) has generally been thought of as a movement disorder however other health-related symptoms, known as non-motor symptoms, are also very common.
- Trial name
- NCT04837976
- Testing
- Semi-structured interviews and a consensus workshops using nominal group techniques.
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Patients With Parkinson's Disease
Evaluation of Bilateral Gamma Knife Thalamotomy in Patients Presenting With Severe Essential Tremor
Essential tremor (ET) is the most frequent movement disorder. Its prevalence is about 1/200 implying that at least 300 000 peoples are concerned in France. Its frequency increase with age (14% of patients 65 yo).
- Trial name
- VIMBIL (NCT02827955)
- Testing
- Gamma Knife® radiosurgery bilateral
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson's Disease
Efficacy and Safety of Carbidopa/Levodopa/Entacapone in Patients With Parkinson's Disease Requiring Initiation of Levodopa Therapy
The CELC200A2401 study has been designed in order to evaluate the hypothesis that administering the combination carbidopa/levodopa/entacapone at the time that levodopa therapy is initiated results in a decrease in the risk of the…
- Trial name
- STRIDE-PD (NCT00099268)
- Testing
- Carbidopa/levodopa/entacapone, Immediate release carbidopa/levodopa
- Where
- 73 sites in United States, Austria and 12 more
- Volunteers
- 747 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease
A Trial of Fecal Microbiome Transplantation in Parkinson's Disease Patients
48 PD patients (age 35-75y; H\&Y 1-3) testing positive in a stool PD-dysbiosis test will be randomized in a 2:1 ratio to receive either donor FMT or their own stool through intracaecal infusion.
- Trial name
- NCT04854291
- Testing
- Administration of donor FMT
- Where
- 4 sites in Finland
- Volunteers
- 51 people
- Sponsor
- Helsinki University Central Hospital
Parkinson Disease
Effect of Metformin as Add-on Therapy in Levodopa Treated Parkinson's Disease Patients
The goal of this clinical trial is to learn that metformin has effect on motor aspects of daily living and oxidative stress in levodopa treated Parkinson disease patients. Researcher will compare drug metformin to a placebo.
- Trial name
- NCT07055958
- Testing
- Metformin
- Where
- Bangladesh
- Volunteers
- 74 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Impulse Control Disorder, Parkinson Disease
rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease
This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control…
- Trial name
- NCT06237868
- Testing
- rTMS Active
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- West Virginia University
Parkinson's Disease
Multicentre Study in Four Parallel Groups of Parkinson's Disease (PD) Patients
The purpose of this study is to investigate the tolerability and the effect of BIA 9-1067 at steady-state on the levodopa pharmacokinetics in Parkinson's Disease (PD) patients treated with levodopa/dopa-decarboxylase inhibitor.
- Trial name
- NCT01568047
- Testing
- BIA 9-1067, Levodopa/Carbidopa, Levodopa/Benzerazide
- Where
- 7 sites in Romania, Ukraine
- Volunteers
- 40 people
- Sponsor
- Bial - Portela C S.A.
Parkinson Disease, Virtual Reality
Upper Extremity Rehabilitation With Virtual Reality in Parkinson's Disease Patients
Upper extremities are the first part of the body to be affected by Parkinson's disease. Although studies have shown that virtual reality-assisted rehabilitation methods are effective on gait and balance, studies on their use for…
- Conditions
- Parkinson Disease, Virtual Reality, Neurological Rehabilitation, Upper Extremity Dysfunction
- Trial name
- NCT06147726
- Testing
- Upper extremity position matching exercises in virtual reality, Conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ramazan KURUL
Parkinson's Disease
Voltage Only Adjustment Versus Multiple Parameters Adjustment of Bilateral STN DBS Treatment in PD Patients.
The programming of subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson's disease (PD) is complex work because the parameter setting has not been standardized so far.
- Trial name
- VOMPDS (NCT01934881)
- Testing
- voltage adjustment only, Multiple parameters adjustment
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chen Ling
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