Clinical trials: Parkinson
Lewy Body Disease, Parkinson Disease Dementia
Learning to PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia
The investigators propose to adapt, improve, and implement a peer mentor support and caregiver education (PERSEVERE) program to improve LBD-specific caregiving mastery.
- Conditions
- Lewy Body Disease, Parkinson Disease Dementia, Dementia With Lewy Bodies
- Trial name
- NCT04649164
- Testing
- Peer mentor support and caregiver intervention, Focus group to provide feedback on educational materials and mentoring program
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Cerebral Oxygenation
Cerebral Oxygenation During Gait in Elderly
Ageing is accompanied by a cognitive decline altering gait and increasing the risk of falling. Physical activity could reduce this cognitive decline by an improvement in the oxygen supply to the brain.
- Trial name
- OXYSENIOR (NCT04045444)
- Testing
- walking, cognitive task
- Where
- France
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Parkinson's Disease
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease
Balance and gait problems cause severe impairments for people with Parkinson's disease In some Parkinson's disease patients the investigators see a loss of acetylcholine in the brain.
- Trial name
- UDALL (NCT02458430)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson's Disease
Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic…
- Trial name
- NCT04799470
- Testing
- Novel DBS stimulation patterns
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Registry
With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NDD Registry (NCT04472130)
- Where
- Hong Kong
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Vincent Mok
Parkinson's Disease Psychosis
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
Patients with Parkinson's disease (PD) sometimes experience symptoms affecting their movement, such as slowness, tremor, stiffness, and balance or walking problems.
- Trial name
- C-SAPP (NCT04373317)
- Testing
- Pimavanserin, Quetiapine
- Where
- 24 sites in United States
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson Disease, Freezing of Gait Symptoms in Parkinson Disease
Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease
This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease.
- Trial name
- NCT07695233
- Testing
- Excitatory Stimulation, Inhibitory Stimulation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Robert Chen
Alzheimer's Disease, Parkinson's Disease
Taxonomy of Neurodegenerative Diseases : Observational Study in Alzheimer's Disease and Parkinson's Disease
The AETIONOMY project will generate a refined taxonomy and testable mechanisms underlying the derived stratification of patients.
- Trial name
- AETIONOMY (NCT05040048)
- Testing
- Clinical, biological and imaging assessment
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson's Disease, Essential Tremor
Sensory Gating Measured With Microelectrode Recording (MER) During Deep Brain Stimulation (DBS) Surgery
Deep brain stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's disease (PD), Essential Tremor (ET), Dystonia and Obsessive Compulsive disorder (OCD).
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia, Obsessive Compulsive Disorder
- Trial name
- NCT02320266
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson's Disease
Cholinergic Nicotinic Receptors and Cognition in PD
Mild cognitive impairment and dementia are frequent non-motor complications of moderate to advanced Parkinson's disease. Brain positron emission tomography (PET) study findings confirm post-mortem evidence that cholinergic loss…
- Trial name
- CHONI (NCT02076295)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson's Disease
A Multiple-Dose Study of Sinemet® CR (Carbidopa/Levodopa) in Healthy Subjects
The purpose of this clinical research study is to determine if different dosage regimens of Sinemet® CR (Carbidopa/levodopa) are dose proportional
- Trial name
- NCT00460954
- Testing
- Sinemet® controlled release (Carbidopa/levodopa)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Parkinson Disease
Chinese DENOVO PD Registry
The main objective of this longitudinal, multi-center study is to explore the clinical characteristics of PD and confirm biomarkers for PD evolution or progression.
- Trial name
- NCT05767151
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Parkinson Disease
Relationship of Dopamine to Cognitive Function in Parkinson's Disease
This study will examine how the brain chemical dopamine affects memory, reasoning, and other thought processes in people with Parkinson's disease with and without dementia and in healthy control subjects.
- Trial name
- NCT00094601
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Parkinson's Disease
Antigen Presentation and Lymphocyte Response in Parkinson's Disease
The way the immune system responds to certain PD-related proteins in PD donors compared to the way it responds in persons without or fewer PD related proteins is not well studied and this study aims to analyze the autoimmune…
- Trial name
- NCT02939534
- Where
- 3 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Columbia University
Autonomic Failure, Pure Autonomic Failure
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia.
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Parkinson Disease, Multiple System Atrophy
- Trial name
- NCT04246437
- Testing
- [18F]FDOPA, Carbidopa 200mg oral dose, Entacapone 400mg oral dose
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Daniel Claassen
Deep Brain Stimulation, Parkinson Disease
Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with…
- Trial name
- NCT06960096
- Testing
- DBS combined with fMRI
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Parkinson Disease
Flexible Reaching Control in Parkinson Disease
Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g.
- Trial name
- REACH-PD (NCT05908266)
- Testing
- Reaching movements, Disease Assessment
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Parkinson Disease
A Study Evaluating Potential Screening Tools for Detecting Parkinson Disease
This study is designed as a prospective cohort study to test the strategy of combining two biomarkers of parkinsonism, olfaction and brain imaging with a radioactively labeled drug, [123I]β-CIT , in a population of first-degree…
- Trial name
- NCT00387075
- Testing
- [123I]β-CIT and SPECT imaging, [123I]β-CIT
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson's Disease, PD
iPACES v3 MCI NIA Protocol Copied for iPACES v4 PD NINDS
The primary purpose of this study is to attempt to replicate and extend promising pilot findings regarding the cognitive benefits of in-home neuro-exergaming with iPACES (interactive Physical and Cognitive Exercise System v3) for…
- Conditions
- Parkinson's Disease, PD, Mild Cognitive Impairment, MCI
- Trial name
- iPACES-PD (NCT05810454)
- Testing
- iPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- iPACES LLC
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