Clinical trials: Parkinsonian Syndromes
REM Sleep Behavior Disorder, Parkinson Disease
A Study of Efficacy and Safety of Idebenone Vs. Placebo in Prodromal Parkinson Disease
To investigate whether 24 months of idebenone may reduce the progression from Prodromal Parkinson disease (PPD) to Parkinson disease (PD).
- Trial name
- SEASEiPPD (NCT04152655)
- Testing
- Idebenone
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson Disease
Development of Digital Diagnostic Devices for Parkinson's Disease
In this project, ocular motor, pupil and gait data in people with Parkinson's disease (PD) will be collected in order to develop machine learning models for the diagnosis and monitoring of PD.
- Trial name
- NCT06663826
- Testing
- oculomotor and pupillary function assessment
- Where
- Switzerland
- Volunteers
- 116 people
- Sponsor
- machineMD AG
Parkinson's Disease and Parkinsonism
Aim 3 Particle Swarm Optimization PIGD
In Parkinson's disease (PD) patients undergoing standard-of-care Deep Brain Stimulation (DBS) therapy, to compare the effect on Parkinson's symptoms of two different neurostimulator settings designed to differ from each other as…
- Trial name
- NCT05934747
- Testing
- DBS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Parkinson Disease, Mood
The Benefits of Nature for Mood and Cognition in Persons With and Without Parkinson's Disease
This online study aims to explore the benefits of nature for mood and cognition in persons with and without Parkinson's disease.
- Conditions
- Parkinson Disease, Mood, Cognition
- Trial name
- NCT06483126
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Schizophrenia, Psychosis
Effects of Rhythmic Auditory Stimulation on Movements in Individuals at Risk for Psychotic Onset and Schizophrenia Patients
The purpose of this research is to examine effects of movement training with the aid of rhythmic auditory stimulation (RAS) on reducing severity of dyskinesia and bradykinesia in at-risk individuals and schizophrenia patients.
- Conditions
- Schizophrenia, Psychosis, Parkinsonism, Dyskinesias
- Trial name
- NCT04553835
- Testing
- Rhythmic auditory stimulation (RAS) for schizophrenia patients, No RAS for schizophrenia patients, RAS for at-risk individuals
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr WANG Shumei
Parkinson Disease
CS1P1 PET Studies of Neuroinflammation in Parkinson Disease
Parkinson disease (PD) is a progressive neurological disorder strongly linked to advancing age that results in decline in mobility and thinking.
- Trial name
- NCT06084533
- Testing
- [11C]-CS1P1
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Parkinson Disease, Fall
Steps Against the Burden of Parkinson's Disease - RCT Kiel
Parkinson's disease (PD) affects over 10 million worldwide, causing unstable gait and falls in 70% of patients despite medication. This leads to confidence loss, isolation, fractures, and hospitalizations.
- Trial name
- StepuP (NCT07058285)
- Testing
- Speed-dependent treadmill training (SDTT), SDTT+ anteroposterior perturbations
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Kiel
Parkinson's Disease, Chronic Appendicitis
A Study Assessing the Effects of Acupuncture in Parkinson's Disease Patients With Chronic Appendicitis
The incidence of PD is high, and when the disease is serious to a certain extent, the effect of drugs to control symptoms decreases, resulting in a significant reduction in the quality of life of patients.
- Conditions
- Parkinson's Disease, Chronic Appendicitis, Acupuncture
- Trial name
- NCT06304285
- Testing
- Acupuncture treatment
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Progressive Supranuclear Palsy, Cortico Basal Degeneration
Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes
The study will compare health care utilisation and quality of life for patients with progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy in different parts of the region that our specialist clinic…
- Conditions
- Progressive Supranuclear Palsy, Cortico Basal Degeneration, Multiple System Atrophy
- Trial name
- UHSQOLAPS (NCT06645626)
- Where
- United Kingdom
- Volunteers
- 198 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Parkinson Disease
Treadmill Training in People With Parkinson's Disease
The study will explore if coupling speed and cadence during treadmill training elicit more benefits than controlling speed alone in individuals with Parkinson's disease.
- Trial name
- NCT05239026
- Testing
- Advanced treadmill walking, Traditional treadmill walking
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Georgia State University
PARKINSON DISEASE (Disorder)
Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Counteract Dopaminergic Desensitization and Neuropsychiatric Complications in Parkinson's Disease
This study is a Phase III multicentric randomized controlled trial with parallel group design and waiting list in patients that have an indication to undergo intestinal L-Dopa + entacapone (Lecigon®) under the existing indication…
- Trial name
- INITIATE-LECIG (NCT07151378)
- Testing
- LECIG (levodopa, carbidopa, entacapone intestinal gel), Best oral medication
- Where
- 7 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Parkinson Disease
Pramipexole Extended Release Versus Pramipexole Immediate Release for 18 Weeks in Chinese Parkinson's Disease (PD) Patients
The objective of this trial is to evaluate non-inferiority of pramipexole Extended release to Immediate release at 18 weeks on the primary efficacy endpoint (Unified Parkinson's Disease Rating Scale II+III) in Chinese PD patients…
- Trial name
- NCT01191944
- Testing
- pramipexole immediate release tablet, pramipexole extended release tablet
- Where
- 20 sites in China
- Volunteers
- 475 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease
Pilot Trial of Transnasal Nicotine in Parkinson Disease
The widely observed inverse relationship between smoking and Parkinson's Disease (PD) and the results of numerous preclinical studies indicating neuroprotective effects of nicotine, suggest a possible novel intervention in PD.
- Trial name
- NCT03865121
- Testing
- Nicotine Nasal Spray 10 MG/ML (0.5 MG/SPRAY)
- Where
- Mexico
- Volunteers
- 6 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Parkinson Disease
Melatonin on Clock Genes in Parkinson's Disease
Parkinson's disease (PD) is the second most important neurodegenerative disease that affects about 2% of the population over 60 years of age.
- Trial name
- NCT04287543
- Testing
- Melatonin
- Where
- Mexico
- Sponsor
- Instituto Mexicano del Seguro Social
Parkinson's Disease, Overactive Bladder
Anticholinergic Therapy for Overactive Bladder in Parkinson's Disease
The purpose of this research study is to investigate the cognitive (thinking, memory, knowledge, intelligence) side effects of two medications commonly used to treat overactive bladder (OAB) symptoms in veteran patients with…
- Trial name
- NCT00892450
- Testing
- Oxybutynin and darifenacin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease
ExAblate Transcranial MRgFUS of the Subthalamic Nucleus for Treatment of Parkinson's Disease
This is primarily a safety protocol to evaluate the safety of subthalamotomy using Transcranial ExAblate for treatment of Parkinson's Disease (PD) motor features.
- Trial name
- NCT02246374
- Testing
- ExAblate Transcranial System
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- InSightec
Parkinson Disease
Comparative Effects of Virtual Reality and Proprioceptive Neuromuscular Facilitation in Patients With Parkinson's Disease
Parkinson's Disease is a chronic neurodegenerative disorder marked by the progressive loss of dopaminergic neurons in the substantia nigra and accumulation of α-synuclein (Lewy bodies).It impacts both motor and non-motor systems…
- Trial name
- VR PNF RPT PD (NCT07308093)
- Testing
- Intervention 1, artificial intelligence
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Parkinson's Disease
Vestibulopathy as a Cause of Imbalance in Parkinson
Balance problems and falls are common in people with Parkinson's disease but respond poorly to dopamine stimulating medications suggesting other causes.
- Trial name
- NCT04768647
- Testing
- TNM
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Safety, Tolerability and Effects of Mannitol in Parkinson's Disease
Parkinson's disease is a progressive neurodegenerative disease that causes disabling motor and cognitive impairments. Currently, no disease-modifying therapy exists for this disease.
- Trial name
- PD-mannitol (NCT03823638)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Parkinson's Disease, Overactive Bladder
Safety and Efficacy of Botulinum Toxin A for Treatment of Overactive Bladder in Parkinson's Disease
A randomized controlled trial is to be conducted to confirm the efficacy and safety of intramuscular injection of botulinum toxin in the treatment of Parkinson's bladder overactivity.
- Conditions
- Parkinson's Disease, Overactive Bladder, Onabotulinumtoxin A
- Trial name
- NCT05997043
- Testing
- oral anti-Parkinson drugs and injection of botulinum toxin, oral anti-Parkinson's drugs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
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