Clinical trials: Parodontitis
Chronic Periodontitis
Efficacy of Herbal Dentifrice in Treatment of Chronic Periodontitis
The study will be a single center, longitudinal prospective, triple blind (investigators, patients and statistician), randomized design.
- Trial name
- NCT06043687
- Testing
- Dentifrice Paste
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Periodontal Diseases, Bone Diseases
Regenerative Potential of a Collagen Membrane Associated or Not to Bovine Bone in Class II Furcation Defects.
Periodontal disease is an infectious-inflammatory disease that accommodates the supporting and supporting tissues of the teeth, with the formation of periodontal pockets, and this destruction can generate anatomical defects in…
- Trial name
- RPPCMABBICFD (NCT04450849)
- Testing
- guided tissue regeneration with using an absorbable collagen membrane associated with inorganic bovine bone associated., guided tissue regeneration with using an absorbable collagen membrane associated or not with inorganic bovine bone associated with collagen matrix.
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis
Periodontal Phenotype and Scaling and Root Planing
Periodontal phenotype has been recognized as one of the key factors that may potentially impact the outcome of a variety of periodontal surgical and non-surgical procedures.
- Trial name
- NCT05449938
- Testing
- Scaling and root planing
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Diabetes Mellitus, Type 2, Apical Periodontitis
Association of Apical Periodontitis With Systemic Level of Inflammatory Markers : A Longitudinal Intervention Study
While cross-sectional studies have reported a significant association between diabetes and Apical Periodontics, prospective studies are scarce.
- Trial name
- NCT05814965
- Testing
- endodontic treatment in the form of root canal treatment, endodontic treatment, assessment of inflammatory marker
- Where
- India
- Volunteers
- 280 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Hypertension
Effect of Non-surgical Periodontal Therapy in Hypertensive Patients With Assessment of Endocan and TNF-α Levels in GCF
There is a strong crossway relationship between periodontitis and hypertension. Hypertension is the most prevalent of cardiovascular diseases and its prevalence is increased by the presence of periodontitis.
- Conditions
- Periodontitis, Hypertension, TNF Alpha, Endocan
- Trial name
- NCT06627192
- Testing
- NSPT, clinical and biochemical assesment
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Apical Periodontitis
Effect of Apical Patency on Success of Root Canal Treatment in Non Vital Teeth
Maintaining Apical patency during root canal treatment is a widely followed methodology in modern endodontic treatment protocols.
- Trial name
- NCT03454815
- Testing
- Apical patency
- Volunteers
- 65 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Smoking Habit
Effects of Smoking on Clinical and Microbiological Response in Individuals With Periodontitis
This study aimed to compare the distribution of subgingival periodontal pathogens following non-surgical periodontal therapy in smoking and non-smoking people with periodontitis.
- Conditions
- Periodontitis, Smoking Habit, Subgingival Plaque
- Trial name
- NCT06383455
- Testing
- Non-surgical periodontal therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Trakya University
Irreversible Pulpitis With Apical Periodontitis
Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis
This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion.
- Trial name
- NCT07768852
- Testing
- Full pulpotomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Periodontitis
Assesment of Gingival Crevicular Fluid and Serum ErbB4/Neuregulin-4 Levels in Periodontal Disease and Health
This study aimed to investigate gingival crevicular fluid (GCF) and serum ErbB4 and Nrg4 levels in periodontal health and disease.
- Trial name
- NCT04051385
- Testing
- non surgical periodontal treatment, Gingival crevicular fluid and serum collection
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Gingivitis, Periodontitis
A Clinical and Imaging Study to Evaluate a Novel Dentifrice
There is a need for toothpastes that more effectively remove oral biofilm, inhibit biofilm re-formation and support periodontal health.
- Conditions
- Gingivitis, Periodontitis, Dental Plaque
- Trial name
- NCT02271815
- Testing
- Oral Hygiene
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- University of California, Irvine
Chronic Apical Periodontitis
Comparison of Anti-microbial Efficacy of Calcipex and Metapex in Endodontic Treatment of Chronic Apical Periodontitis
Introduction: Pulpal necrosis may lead to spread of the infection from the pulp to involve the apex of the tooth and surrounding bone which when asymptomatic with periapical radiolucency on radiograph, is called chronic apical…
- Trial name
- NCT04336709
- Testing
- Calcipex II, Metapex
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Aga Khan University
Chronic Periodontitis, Type2 Diabetes
1.2% Rosuvastatin Subgingivally Delivered In Chronic Periodontitis With Type 2 Diabetes Mellitus
The purpose of the present study was to evaluate the effects of subgingival delivery of 1.2% Rosuvastatin (RSV) gel as an adjunct to scaling and root planing in chronic periodontitis (CP) with Type 2 diabetes mellitus patients.
- Trial name
- NCT02985099
- Testing
- SRP plus Rosuvastatin gel
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontitis, Adult
Utilization of a Periodontal Endoscope in Nonsurgical Periodontal Therapy
The purpose of this study was to compare the clinical outcomes of teeth deep cleaning or scaling and root planing (SRP) using a periodontal endoscope (Perioscopy®) versus traditional SRP using magnifying loupes for up to twelve…
- Trial name
- NCT05293301
- Testing
- Use of Periodontal Endoscope (Perioscopy®) to enhance visualization while performing teeth deep cleaning, Use of traditional loupes to enhance magnification to enhance visualization while performing teeth deep cleaning
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Irriversible Pulpitis With Apical Peridontitis, Hot Tooth
Effect of Cryotherapy and Laser Application on Post-Operative Pain in Single Visit Endodontically Treated Symptomatic Apical Periodontitis Cases
This study compare the effect of applying ice after single visit endodontic treatment with lasers to reduce post operative pain .
- Trial name
- LLLT (NCT06657664)
- Testing
- cryotherapy with sterile saline at 2.5ºC, intaoral cryotherapy, Both intracanal and intraoral cryotherapy
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Tanta University
Chronic Periodontitis
Evaluation of Acacia Catechu and Low-Level Laser in the Treatmentof Stage II Periodontitis
Evaluation of Acacia catechu and Low-Level Laser in the Treatment of Stage 2 Periodontitis.
- Trial name
- LLLvsAgel (NCT06805292)
- Testing
- Acacia catechu, Low Level Laser Therapy, phase 1 therapy chronic periodontitis
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Faculty of Dental Medicine for Girls
Periodontal Diseases, Gingivitis
Asprosin, Adropin, Irisin Levels in Periodontitis
The recently discovered association of the hormones 'asprosin, adropin and irisin' with obesity and metabolic status, as well as the fact that periodontal diseases are affected by obesity and nutrition bilaterally, have led us to…
- Conditions
- Periodontal Diseases, Gingivitis, Obesity
- Trial name
- NCT06250764
- Testing
- Clinical periodontal measuremenets, ELISA test from gingival crevicular fluid (GCF)
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- AYSAN LEKTEMUR ALPAN
Chronic Periodontitis
To Study the Healing Effect of 0.25% Lemongrass Oil Mouthwash on Chronic Periodontitis Patients.
Periodontitis is the inflammation of the tissues supporting the teeth. Lemongrass (Cymbopogon Citratus) oil mouthwash can be used with subgingival scaling in the treatment of periodontal diseases.
- Trial name
- NCT05502627
- Testing
- 0.25% lemon grass oil mouthwash
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Medical Institute, Lahore
Periodontitis
Efficacy and Safety of LP-005 Injection in Patients With Moderate-to-Severe Periodontitis
This is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical study designed to evaluate the clinical efficacy, safety, pharmacokinetics, pharmacodynamics, and immunogenicity of multiple local injections…
- Trial name
- NCT07603713
- Testing
- LP-005 Injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Longbio Pharma (Suzhou) Co., Ltd.
Periodontal Diseases, Periodontal Pocket
Occlusal Load Distribution and Periodontal Status
Occlusal forces are unevenly distributed among teeth during mastication, potentially predisposing certain teeth to higher functional loads.
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontitis, Periimplantitis
- Trial name
- Perio-Occlusio (NCT07199062)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Stage II and III Periodontitis
Effectiveness of Topical Fluoroquinolone Gel in Treating Stage II/III Periodontitis
The goal of this clinical trial is to investigate the effect of local application of levofloxacin gel on healing of periodontal pockets in patients with stage II/III periodontitis. The main questions it aims to answer are: 1.
- Trial name
- NCT07892261
- Testing
- Levofloxacin in-situ gel, Professional mechanical plaque removal
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Naira Mohammed
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