Clinical trials: Pathogenesis
Muscular Diseases
The Role of Ischaemia-reperfusion Injury in the Pathogenesis of Muscle Wasting After Thoracic Aortic Surgery
Single-centre observational study over one year investigating the mechanisms of muscle homeostasis in patients with acute skeletal muscle atrophy following major aortic surgery
- Trial name
- RIMMAS (NCT03354767)
- Testing
- Aortic and aortic valve surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Lymphangiomatosis, Lymphedema
Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders
Background: Lymphatics are a type of vessel, similar to arteries and veins. Lymphatic disorders happen when these vessels don t work properly.
- Conditions
- Lymphangiomatosis, Lymphedema, Lymphangiectasia, Pulmonary Lymphangiectasia
- Trial name
- NCT02156115
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chikungunya, Arthritis
Chikungunya Arthritis in the Americas
Chikungunya is a mosquito-borne viral illness that leads to chronic joint pain in approximately one half of patients. The mechanisms leading to long term arthritis in humans has not been well established.
- Trial name
- NCT02463968
- Testing
- Venipuncture for blood draw, Arthrocentesis for synovial fluid draw
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- George Washington University
Dry Eye, Ocular Inflammation
Closed Eye Neutrophils in Dry Eye Disease
The purpose of this prospective study is to evaluate different inflammatory cells that accumulate on the ocular surface, during sleep, and how these cells may contribute to dry eye disease.
- Trial name
- NCT03332342
- Testing
- Eye wash
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Psoriasis
Characterization of Cutaneous Microbiota in the Psoriasis Pathogenesis
The skin harbors a complex and dynamic microbiota constituted by numerous microorganisms that live in symbiosis with the host. The specific etiology of psoriasis is still not-well understood; nonetheless several studies…
- Trial name
- MICROBIOTA (NCT03475914)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Dementias, Neurodegenerative Dementia
In-depth Analysis of Cholesterol Metabolism and Related Biomarkers in the Pathogenesis and Progression of the Disease in Neurodegenerative Dementias
The aim of the study is to evaluate the role of cholesterol in the pathogenesis of neurodegenerative dementias. Hypercholesterolemia is a known risk factor for Alzheimer disease (AD), and oxysterols, the principal cholesterol…
- Trial name
- RF-2021-123742 (NCT07207486)
- Where
- 2 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Sick Sinus Syndrome
The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome
Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system.
- Trial name
- NCT01310920
- Testing
- observation
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Chronic Obstructive Pulmonary Disease
Study on the Etiology, Risk Factors and Pathogenesis of COPD Based on Clinical Bioinformatics
The risk factors and causes of chronic obstructive pulmonary disease（COPD）are not clear, so the prevalence of COPD is high and the prevention effect is not good.
- Trial name
- NCT05069194
- Where
- China
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Neurodegenerative Disorders
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5).
- Trial name
- NCT00874783
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Saliva, Oral Lichen Planus
Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics
The goal of this observational study is to compare salivary proteome profiles in patients with Oral Lichen Planus (OLP), Oral Leukoplakia (OL), and healthy individuals without oral mucosal disease.
- Conditions
- Saliva, Oral Lichen Planus, Oral Leukoplakia, Proteomics
- Trial name
- NCT07416318
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Crohn Disease (CD)
The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease
The goal of this study is to find out if there is a direct connection between an imbalance of gut bacteria and the development of scar tissue in the gut by identifying important bacterial proteins found in scarred gut tissue.
- Trial name
- NCT06720961
- Testing
- Collection of surgical specimen, Collection of stool sample
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Type 1 Diabetes, De Novo Lipogenesis
Pathogenesis of the Cardiometabolic Risk in Youth With Type 1 Diabetes
The purpose of this study is to quantitate hepatic de novo lipogenesis (DNL) in youth with poorly-controlled type 1 diabetes (T1D) (HbA1c >8.5%), youth with T1D who achieve targeted glycemic control (HbA1c <7.5%) and lean…
- Trial name
- NCT04101045
- Testing
- Oral Glucose Tolerance Test
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Yale University
Arthritis, Rheumatoid, Neovascularization, Pathologic
Preliminary Study of Sonic Hedgehog Signaling Pathway in the Pathogenesis of Rheumatoid Arthritis
Rheumatoid arthritis(RA) with a high incidence and high morbidity, the pathogenesis has not been fully elucidated. Fibroblast-like synovial cells excessive proliferation and synovial angiogenesis is the most important cause of RA…
- Conditions
- Arthritis, Rheumatoid, Neovascularization, Pathologic, Synovitis
- Trial name
- NCT01731262
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Atrial Fibrillation
Autoimmunity in the Pathogenesis of AF
This research study is being done to find out whether autoimmune mechanisms are associated with the development of atrial fibrillation.
- Trial name
- NCT03498729
- Testing
- Peripheral Blood Sample
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Osteoarthritis (OA)
Research on the Pathogenesis and Therapeutic Targets of Articular Cartilage Degeneration in Osteoarthritis
Before you are included in this study, you will undergo the following examinations to determine if you are eligible to participate: Before you are included in this study, your doctor will ask and record your medical history…
- Trial name
- NCT07796607
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yunnan University of Chinese Medicine
Obesity
Relation of Blood-boron Levels With Body Mass Index
According to our experimental experiences w hypothesized that blood boron levels may be corralated to body mass index.
- Trial name
- NCT01400061
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- SB Istanbul Education and Research Hospital
Colorectal Cancer, Colorectal Cancer Metastatic
Possible Association of Intestinal Helminths and Protozoa With Colorectal Cancer Pathogenesis
Colorectal cancer (CRC) has the third highest cancer incidence in the world. There is mounting evidence that the intestinal microbiota plays an important role in colorectal carcinogenesis.
- Conditions
- Colorectal Cancer, Colorectal Cancer Metastatic, Intestinal Parasite, Protozoan Infections
- Trial name
- NCT03173001
- Testing
- Parasitological examination
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Preeclampsia
The Role and Mechanism of GPER-Hippo-CBS/H2S Pathway in Preeclampsia
The goal of this clinical trial is to learn about in health conditions. The main questions it aims to answer are: The pathological significance of GPER in uterine artery dilation in preeclampsia The Mechanism of GPER Hippo…
- Trial name
- NCT06205771
- Testing
- H2S content
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hao Feng
Monoclonal Gammopathy of Undetermined Significance (MGUS), Intestinal Flora
Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy
This is an observational case-control study, aiming to systematically analyze the gut microbiome characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS).
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Intestinal Flora, Multiple Myeloma, M-Protein
- Trial name
- NCT06690593
- Where
- China
- Volunteers
- 2,990 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Anemia, Chronic Heart Failure
Hepcidin in Anemic Chronic Heart Failure (CHF) Patients
Background: Anemia in chronic heart failure (CHF) is directly linked to increased mortality and reduced exercise capacity. The pathomechanism for the development of anemia in CHF is not well understood.
- Trial name
- NCT00437866
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna