Clinical trials: Pathologic Response
HPV Infection, Cervical Cancer
Effector and Memory Immune Responses to HPV Vaccination in Vietnamese Women Post Virus Exposure
A Study to evaluate if the 3 dose extended schedule (0-6-18 months) for the HPV vaccine Gardasil-9 provide similar immune responses and short term protection against HPV infection compared to the regular 3 dose schedule (0-2-6…
- Conditions
- HPV Infection, Cervical Cancer, Anogenital Cancer, Anogenital Warts
- Trial name
- HPV9vxFSW (NCT06681636)
- Testing
- Human papillomavirus 9-valent vaccine, Recombinant
- Where
- 3 sites in Australia, Vietnam
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Hygiene and Epidemiology, Vietnam
Cardiovascular Disease
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.
- Trial name
- NCT06263452
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Sepsis, Severe Sepsis
Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a fluid treatment-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03752489
- Testing
- Treatment-specific InSight, InSight
- Volunteers
- 51,645 people, healthy volunteers welcome
- Sponsor
- Dascena
Obesity, Diabetes
The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children
This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children.
- Trial name
- NCT02499107
- Testing
- Rice treatment, Pasta treatment, Boiled and mashed potato treatment
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity, Social Dominance
Subjective Social Status and Energy Balance
Investigators examined the associations between SSS, energy balance, food intake and changes in body composition following a high calorie lunch for 2 weeks.
- Conditions
- Obesity, Social Dominance, Social Behavior, Eating Behavior
- Trial name
- NCT03510364
- Testing
- Dietary intervention
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Neonatal Sepsis, Necrotizing Enterocolitis
Bovine Lactoferrin and Neonatal Survival in Low Birth Weight Babies.
Pakistan has the third highest number of neonatal deaths worldwide. During the last two decades (1990-2013), neonatal mortality rate in the country has declined by only 1.0% per year.
- Trial name
- NCT03431558
- Testing
- bLF (Bovine lactoferrin)
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Sepsis
Prevention of Infection in Indian Neonates - Phase I Observational Study
India, with one of the world's largest populations, continues to struggle with extremely high infant and neonatal mortality rates.
- Trial name
- NCT00518609
- Where
- 3 sites in India
- Volunteers
- 1,326 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Medical Education, Simulation Training
Effectiveness of Simulation Based Training in Implementing One Hour Bundle Sepsis
This study aimed to compare simulation training with conventional training (case-based discussion only) to improve team performance in implementing one-hour sepsis bundle in the intensive care unit
- Conditions
- Medical Education, Simulation Training, Sepsis
- Trial name
- NCT05076721
- Testing
- Simulation training, Case-based discussion training
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Parkinson Disease
Neural Control of Breathing in Parkinson's Disease
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder.
- Trial name
- NEURON-PD (NCT06074614)
- Testing
- Hypercapnic ventilatory response, Respiratory related evoked potential, Transcranial magnetic stimulation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Immune Response, Birth Weight
Impact of Electronic Cigarettes on Perinatal Immune Responsiveness and Birth Outcomes
There has been a dramatic escalation of electronic cigarette (e-cig) use among women of childbearing age, including pregnant women.
- Conditions
- Immune Response, Birth Weight, Gestational Age
- Trial name
- NCT02553577
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Kristin Ashford
Psychological Phenomena and Processes, Nutrition Physiological Phenomena
The Effects of Fiber on Appetite and Digestion Hormones
In this research study, investigators are interested in how certain dietary fibers in the diet affect certain hormones released from your intestine after eating and how these influence your appetite.
- Trial name
- FS (NCT01050101)
- Testing
- No fiber, Low GI high fiber viscous meal, Low GI high fiber non-viscous
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Laparoscopy
Effect of Music on Inflammatory Response During Laparoscopic Surgery
This study evaluates the effect of per-operative music on the bio-molecular inflammatory response in laparoscopic surgery. Per-operative music intervention will be given to the test group via headphones while the control group…
- Trial name
- NCT02827292
- Testing
- music, No music, Laparoscopic Surgery
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sir Ganga Ram Hospital
Hyperventilation, Larynx
Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe Asthmatics.
The Investigators aim to: 1. Study the effect of hyperventilation on the development of paradoxical vocal cord movement (PVCM) in healthy individuals and in patients with mild and severe asthma, 2.
- Conditions
- Hyperventilation, Larynx, Asthma
- Trial name
- NCT05565430
- Testing
- Acute Hyperventilation, Chronic hyperventilation, Effects of anticholinergic medication
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Monash Medical Centre
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
LRTI, Sepsis
Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis
The TAILORED-Treatment consortium was established to develop new tools aimed to increase the effectiveness of antibiotic and antifungal therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in…
- Conditions
- LRTI, Sepsis, Fungal Infections, Bacteremia
- Trial name
- TailoredT (NCT02025699)
- Where
- Israel
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Healthy Volunteers, Sepsis
The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation
Severe sepsis still carries a high mortality rate despite advantages in intensive care medicine and antimicrobial therapy. The inflammatory and procoagulant host response to infection are intricately linked and interactions…
- Trial name
- NCT01099566
- Testing
- Prasugrel
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hyperuricemia, Healthy
The Relationship Among, Serum Uric Acid, Left Ventricular Hypertrophy and Metabolic Syndrome
Hyperuricemia is associated with the prevalence of metabolic syndrome and cardiovascular risks in diverse of the population. Whether the dose-response effects on the prevalence of metabolic syndrome and cardiometabolic risks is…
- Trial name
- NCT03473951
- Testing
- Hyperuricemia
- Where
- Taiwan
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Diabetes, Pre-diabetes
Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM)
The investigators know that metformin works at the level of the cells in the body by acting on a protein called Cyclic amine monophosphate- Response Binding Elements (CREB) binding protein or Constitutive Reverter of eIF2α…
- Conditions
- Diabetes, Pre-diabetes, Obesity
- Trial name
- NCT01876992
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Apnea, Obesity
The Effects of Treating Obese and Lean Patients With Sleep Apnea
The investigators' overall goal is to compare the effect of CPAP treatment on intermediate cardiovascular risk measures in obese versus lean patients with obstructive sleep apnea (OSA).
- Trial name
- PISA (NCT01578031)
- Testing
- Positive Airway Pressure During Sleep (ResMed S9 Elite), Usual Care
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Inflammatory Response
Blueberry-protein Supplementation and Exercise
This study is the human clinical trial component of an SBIR grant with Sinnovatek (funded). Cyclists (n=20) will consume a blueberry-protein, blueberry, or placebo supplement for 2 weeks prior to cycling for 2.5 h at high…
- Trial name
- NCT05596500
- Testing
- Blueberry-protein gel, Blueberry gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
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