Clinical trials: Pathological Conditions, Anatomical
Hypertrophy
Food First Approach to Stimulate Muscle Protein Synthesis in Healthy Adults
In a crossover design 10 young healthy adults (20-35 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise.
- Trial name
- Salmon (NCT03870165)
- Testing
- Resistance exercise, Salmon, Isolated amino acids and fatty acids
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Lumbar Herniated Intervertebral Disc
Biportal Endoscopic Discectomy Versus Microdiscectomy: RCT, Non-inferiority Trial
This study is to compare the clinical outcome between the biportal endoscopic discectomy and microdiscectomy in herniated intervertebral disc of lumbar spine
- Trial name
- BESS (NCT03924700)
- Testing
- Biportal endoscopy, Microdiscectomy
- Where
- 2 sites in South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Hospital
Low-output External Gastrointestinal Fistula
Glue Application in the Treatment of Low-Output Fistulas
Adjuvant use of fibrin glue (FG) in the fistula tract has been shown to promote closure of low-output enterocutaneous fistulas (ECFs).
- Trial name
- FG-treatment (NCT01828892)
- Testing
- Endoscopy exploration and glue application, Endoscopy exploration, Antibiotics (ceftazidime, cefotaxime, or meropenem, with or without vancomycin)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jinling Hospital, China
Atrophy
Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes
The proposed project will evaluate the musculoskeletal outcomes of quadriceps and hamstring muscle size and function following orthopedic knee surgery involving anterior cruciate ligament (ACL) repair or reconstruction.
- Trial name
- FAKS-HMB (NCT05869812)
- Testing
- CaHMB (Dietary supplement, not Drug), CaLa
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Leukoplakic Lesions
Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia
Oral leukoplakia is a precancerous lesion with relatively high malignant transformation potential. They are often treated by wide surgical excisions or conservative retinoids therapy.
- Trial name
- NCT03233165
- Testing
- Er:YAG laser, Er,Cr:YSGG laser
- Volunteers
- 54 people
- Sponsor
- University of Zagreb
Idiopathic Dilated Cardiomyopathy
Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart
The primary goal of the study is to measure in the intact human heart, the alterations in gene expression over time that are associated with reverse remodeling in response to β-blockade.
- Trial name
- BORG (NCT01798992)
- Testing
- Carvedilol, Metoprolol succinate, Metoprolol succinate + doxazosin
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of Colorado, Denver
Asthma, Allergies
T Cell Effector and Regulatory Mechanisms in Asthma
The specific hypothesis for this study is that there are fundamental differences in T effector and T regulatory cell responses in the lung to allergens in allergic asthma (AA) when compared to allergic nonasthmatics (ANA) that…
- Trial name
- MGH-001 (NCT01612936)
- Testing
- Bronchoscopy, Segmental Allergen Challenge and Broncheoalveolar Lavage, PET-CT imaging(13NN perfusion/ventilation, 18FDG inflammation, and CT imaging)
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Andrew D. Luster, M.D.,Ph.D.
Incisional Hernia, Cholecystectomy, Laparoscopic
Trocar Site Hernia After Laparoscopic Cholecystectomy, Supra Versus Infraumbilical Incision for Umbilical Trocar Entry
Trocar site hernia is a specific complication of laparoscopic surgery. The increasingly frequent use of the laparoscopic approach has resulted in an increase in the number of hernias, mainly at the umbilical area.
- Trial name
- HOT (NCT04254237)
- Testing
- Infraumbilical Hasson trocar incision, Supraumbilical Hasson trocar incision
- Where
- 3 sites in Spain
- Volunteers
- 130 people
- Sponsor
- Complejo Hospitalario La Mancha Centro
Vaginal Vault Prolapse
Laparoscopic Sacrocolpopexy: Long Term Follow-up
The purpose of this study is to determine the long term results of laparoscopic sacrocolpopexy regarding anatomical results, recurrences, complications, further surgeries required, patients satisfaction and quality of life.
- Trial name
- NCT01394237
- Testing
- Examination
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- Kantonsspital Aarau
Allergic Asthma
Efficacy of Omalizumab in Adults (18-60 Years of Age) With Moderate-Severe, Persistent Allergic Asthma, Despite Receiving Inhaled Corticosteroids and Long Acting Beta-agonists
This study aims to investigate the effect of omalizumab on the number of tissue eosinophils and other markers of airway inflammation and remodeling, including thickness of the lamina reticularis, in moderate to severe asthmatics…
- Trial name
- eXplore (NCT00670930)
- Testing
- omalizumab at a dose of 0.016mg/kg/IU/mL
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary
Involvement of Plasmatic Factors in the Peripheral Muscle Dysfunction of COPD Patients - In Vitro Study
Chronic Obstructive Pulmonary Patients is a defined by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or…
- Trial name
- NCT03197909
- Testing
- Determination of pro-inflammatory plasma factors
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Renal Injury, Kidney Injury
Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract
Given the high recurrence of urolithiasis in patients, the search for less aggressive and preventive treatments is increasingly necessary.
- Conditions
- Renal Injury, Kidney Injury, Kidney Calculi, Ureteral Obstruction
- Trial name
- NCT04695951
- Testing
- Renalof
- Where
- Nicaragua
- Volunteers
- 155 people
- Sponsor
- Catalysis SL
Congenital Diaphragmatic Hernia
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm, the muscle that separates the chest cavity from the abdominal cavity, does not form properly.
- Trial name
- NCT01098929
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pelvic Organ Prolapse, Urinary Incontinence
Vaginal Estradiol Use in Pessary Care
The primary outcome of this study compare the rate of pessary discontinuation at 6 months post-pessary fitting in women using vaginal estradiol versus those not using vaginal estradiol.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Pessary Ulcer of Vagina, Vaginal Atrophy
- Trial name
- NCT05458375
- Testing
- Estradiol vaginal cream
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Bladder Cancer, Prostate Cancer
Occupational Situation and Return to Work of Urological Patients
This study will examine the work status of all adult patients admitted over a 6-month period to the University Hospital in Kraków, Poland, for treatment of urological diseases.
- Conditions
- Bladder Cancer, Prostate Cancer, Renal Cancer, Urinary Stones
- Trial name
- OCCURORTW (NCT07088536)
- Testing
- Occupational Status Survey and Telephone Follow-up and Quality-of-Life Assessment in a subset of patients
- Where
- Poland
- Volunteers
- 2,000 people
- Sponsor
- Jagiellonian University
Colon Cancer, Rectal Cancer
Pilot Study Evaluating the Efficacy of AlloMEM After Loop Ileostomy
The objective of this study is to investigate whether the use of Human Peritoneal Membrane (HPM) in a temporary loop ileostomy is beneficial to patients.
- Trial name
- AlloMem (NCT01113736)
- Testing
- AlloMEM™
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Kidney Stones, Urinary Stone Disease / Nephrolithiasis
Fecal Microbiota Transplantation in Kidney Stone Patients
This open-label pilot study evaluates whether oral microbial transplant therapy can change urine factors associated with recurrent calcium-oxalate kidney stones.
- Conditions
- Kidney Stones, Urinary Stone Disease / Nephrolithiasis, Recurrent Calcium-oxalate Kidney Stones
- Trial name
- FMT IND (NCT05516472)
- Testing
- Microbial Transplant Therapy (FMT CAPSULE DE / FMPCapDE / MTP-CP101), Vancomycin and neomycin antibiotic pretreatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Joshua Stern
End Stage Renal Disease, AV Fistula
Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD
A prospective single-arm well-controlled study to evaluate the safety and effectiveness of a less invasive means of establishing vascular access to facilitate dialysis in patients with end stage renal disease.
- Conditions
- End Stage Renal Disease, AV Fistula, Fistula, End Stage Kidney Disease
- Trial name
- NCT02363972
- Testing
- Ellipsys Vascular Access Catheter
- Where
- 5 sites in United States
- Volunteers
- 103 people
- Sponsor
- Medtronic Endovascular
Urinary Tract Stones, Urinary Stones
ESWL for Distal Ureteric Stone: Supine Versus Prone
Extracorporeal shockwave lithotripsy (ESWL) for urinary stone is common and widespread nowadays. Approximately 80% of urinary stones are treated by ESWL.
- Conditions
- Urinary Tract Stones, Urinary Stones, Urinary Calculi
- Trial name
- NCT02298465
- Testing
- Supine ESWL, Prone ESWL, Extracorporeal Shockwave Lithotripsy (ESWL)
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Queen Mary Hospital, Hong Kong
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