Clinical trials: Pathological Conditions, Signs and Symptoms
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
End Stage Renal Disease
Blood Flow Conditions and Sounds in AVFs
This is a prospective non-pharmacological interventional study aimed at investigating the relationship between the blood flow condition and the arteriovenous fistula (AVF) sound, with the ultimate aim of predicting the AVF…
- Trial name
- APOLLO (NCT06411353)
- Testing
- MRI acquisition, US examination
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Piriformis Syndrome
Comparative Effects of PIR and PFS on Pain, Hip ROM, and Disability in Piriformis Syndrome
This randomized clinical trial evaluates the effectiveness of Post-Isometric Relaxation (PIR) and Post-Facilitation Stretching (PFS) for managing pain, improving hip abduction and internal rotation, and enhancing functional…
- Trial name
- PIR-PFS RCT (NCT07255053)
- Testing
- Post Isometric Relaxation (PIR), Post Facilitation Stretching (PFS)
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Faisalabad
Chronic Kidney Disease Requiring Hemodialysis, Chronic Kidney Disease
Serum circ_DLGAP4, lncRNA KCNQ1OT1, and Their Targets by Erythropoietin Resistance in Chronic Kidney Disease
Non-coding RNAs have evolved as biomarkers and as phased and specific therapeutic targets for chronic kidney disease (CKD). However, their clinical significance in CKD patients is largely unexplored.
- Trial name
- NCT07037953
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anorexia Nervosa
Estradiol and Fear Extinction in Anorexia Nervosa (AN)
The purpose of this study is to determine whether estrogen may help reduce fear of high calorie-density foods in weight-restored women with Anorexia Nervosa (AN).
- Trial name
- NCT02792153
- Testing
- Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease
A Study to Assess the Effects of Dexpramipexole in Participants With Eosinophilic COPD
This is an open-label Phase II study assessing the PD of dexpramipexole 150 mg twice daily (BID) in participants with eosinophilic COPD.
- Trial name
- SUSPIRE-1 (NCT06533553)
- Testing
- Dexpramipexole Dihydrochloride
- Where
- 23 sites in United States
- Volunteers
- 30 people
- Sponsor
- Areteia Therapeutics
Constipation, Gastrointestinal Dysfunction
Effect of Polydextrose on Fecal Bulk and Bowel Function in Mildly Constipated Subjects
Polydextrose (PDX) (8-30g/day) has been reported to increase faecal bulk and consistency, leading to easier stool passage in healthy subjects.
- Trial name
- NCT05309837
- Testing
- Polydextrose
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Tate & Lyle
Sepsis, Vancomycin Treatment
A New Protocol for Continuous Vancomycin Infusion Dosing.
This observational study prospectively collect data on chosen dosing, renal function, measured plasma concentrations and adherence to the recommended clinical protocl for ICU patients treated with continuous vancomycin infusion.
- Trial name
- CVIP (NCT05143645)
- Testing
- Plasma vancoymcin measurements
- Where
- Sweden
- Volunteers
- 101 people
- Sponsor
- Karolinska University Hospital
Obesity, Overweight
Online Platform for Healthy Weight Loss (POEmaS)
Clinical trial to test the efficacy of an online platform based on behavior change principles in promoting weight loss among overweight and obese students and employees of the Federal University of Minas Gerais.
- Trial name
- POEmaS (NCT03435445)
- Testing
- Online platform group, Online dietitian coaching, Control group
- Where
- Brazil
- Volunteers
- 1,276 people
- Sponsor
- Federal University of Minas Gerais
Atrial Flutter, Arrhythmia
RF Lesion Monitoring With 8mm IntellaTip MiFi XP
Abnormal heart rhythms or arrhythmias are often managed by a procedure in which a catheter is introduced into the heart. These catheters can then cauterize abnormally functioning portions of the heart muscle with the hope of…
- Trial name
- NCT02089672
- Testing
- Catheter ablation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Esophageal Achalasia, Gastroparesis
Respiratory and Hemodynamic Implications of Endoscopic Myotomy of the Esophagus and Stomach
The goal of this observational study is to learn about hemodynamic and respiratory repercussions during general anesthesia in patients with achalasia or gastroparesis who underwent an endoscopic treatment such as a peroral…
- Trial name
- NCT05602272
- Testing
- General anesthesia for per-oral endoscopic myotomy
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Inflammation, Migraine
Identification of Inflammatory Markers in Migraine Patients
Migraine is prevalent in 10-12% of the population. It involves the development of a cranial perivascular neurogenic inflammation. Recent information suggests that migraine might be a risk factor to stroke.
- Conditions
- Inflammation, Migraine, Headache
- Trial name
- NCT00969995
- Where
- Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sleep Deprivation, Sleep
Effects of Napping in Sleep-Restricted Adolescents
To examine the neurobehavioural responses to two successive cycles of sleep restriction and recovery in adolescents, and to determine the benefits of napping on cognitive performance, alertness, and mood.
- Trial name
- NCT02838095
- Testing
- Nap
- Where
- Singapore
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Colorectal Cancer
Association of MSI, TS, DPD, MVD and EGFR With Chemosensitivity in Stage IV in Colorectal Cancer
The present project will follow our previous phaseⅡ study of FOLFOX regimens for the treatment of stage Ⅳ colorectal cancer. We will recruit at least 200 patients for this study.
- Trial name
- NCT00173472
- Testing
- Chemotherapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Opioid Misuse and Addiction, Pain
Toward Zero Prescribed Opioids for Outpatient General Surgery
Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the…
- Trial name
- NCT05327777
- Testing
- Oxycodone, Zero Opioid Protocol
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Sepsis, Antimicrobial Resistance (AMR)
Implementation of a Sepsis Chart and Its Effects on Mortality Rate in Indonesian Primary Referral Hospitals
The goal of this observational study is to evaluate the effectiveness of implementing Koran Sepsis, or sepsis chart, a paper-based order set designed to guide the implementation of the One-hour Sepsis Bundle, in improving…
- Trial name
- NCT07843277
- Testing
- Sepsis chart (koran sepsis), Usual care
- Where
- 2 sites in Indonesia
- Volunteers
- 304 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Neuropathic
Pulsed Electromagnetic Field Therapy to a Tailored Exercise Program for Patients Suffering From Chemotherapy-induced Neuropathy Related to Breast Cancer
This research studied the usefulness of a targeted intervention designed to manage chemotherapy-induced symptoms, particularly focusing on pain relief, balance deviations and functional improvements.
- Trial name
- PEMFTEPCHIN (NCT06947577)
- Testing
- pulsed electromagnetic field (PEMF) therapy and a tailored exercise program (TEP), Tailored Exercise Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Birth Outcomes, Labor Pain and to Reduce Pain
The Effect of the Intrapartum Care Model Given in Line With WHO Recommendations on the Birth Process and Care
This study aimed to evaluate the effects of the intrapartum care model provided in line with the World Health Organization (WHO) recommendations on labor pain, fear, comfort, duration, oxytocin use and perception of midwifery…
- Conditions
- Birth Outcomes, Labor Pain and to Reduce Pain, Fear of Birth, Birth Comfort
- Trial name
- NCT06681675
- Testing
- The group that applied the Intrapartum Care Model
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Parkinson's Disease
Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA)
The study will investigate the biomarker of a-synuclein aggregate in CSF detected by protein misfolding cyclic amplification (PMCA) and its sensitivity and specificity in diagnosing Parkinson's disease at H-Y stage I and disease…
- Trial name
- NCT04536857
- Testing
- Biomarker assay
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Huashan Hospital
Mental Illness Persistent, Chronic Disease
Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border
This study evaluated whether patients with severe and persistent mental illness (SPMI) who received coordinated co-located behavioral health and primary care services were more likely to improve health outcomes after 12 months…
- Conditions
- Mental Illness Persistent, Chronic Disease, Hypertension, Diabetes
- Trial name
- NCT03881657
- Testing
- Reverse Colocated Integrated Care, Usual Care
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Health Resources in Action, Inc.
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