Clinical trials: Pathophysiology
Alzheimer Disease, Mild Cognitive Impairment
Flortaucipir PET Imaging in the Preclinical, Prodromal and Dementia Phases of Alzheimer's Disease
A Phase 1 study designed to evaluate imaging characteristics of flortaucipir in the preclinical, prodromal and dementia phases of Alzheimer's disease.
- Trial name
- NCT04468347
- Testing
- Flortaucipir F18, Brain PET scan
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Olfactory Impairment
The Efficacy of Modified Olfactory Training for Patients With Olfactory Dysfunction
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can treat olfactory disorders in adults?…
- Trial name
- NCT06353139
- Testing
- Modified olfactory training device
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Depression, Mild Cognitive Impairment
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
Mild cognitive impairment (MCI) leading to Alzheimer's disease and related disorders (ADRD) represents a significant health and economic burden of the rapidly expanding senior population.
- Trial name
- NCT06011681
- Where
- 2 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Miro Health
Cognitive Impairment
GAME Veterans With PTSD Using Computer-Based Cognitive Training
The investigators hypothesis are as follows: H1a: OEF/OIF veterans with PTSD who perform cognitive training (CT) will demonstrate greater objective improvements on standard (untrained) neurocognitive measures, with the largest…
- Trial name
- NCT01087775
- Testing
- Cognitive Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Karen Seal
Aging, Endothelial Dysfunction
Effect of a Daily Supplement on Plasma PAI-1 Levels
In a healthy person, the production of nitric oxide (NO) by the endothelium, the inner lining of the blood vessel, is responsible for a) the ability of the blood vessel to dilate so it can increase its blood flow and b) act as an…
- Conditions
- Aging, Endothelial Dysfunction, Senescence
- Trial name
- NCT07469475
- Testing
- Supplement with ginger extract, L-citrulline, Paullinia cupana, and muira puama
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Symptomatic Menopause, Cognitive Impairments
Attention & Memory Impairments in Menopausal Women
The purpose of this study is to determine whether a medication called Vyvanse® (lisdexamfetamine; LDX) has an impact on cognitive functioning, specifically measures of sustained attention, verbal encoding and recall and working…
- Trial name
- NCT01324024
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Erectile Dysfunction (ED)
The Feasibility of Using Dornier Machine in Patients With Erectile Dysfunction, a Pilot Study.
Extracorporeal Shockwave Therapy (ESWT) is a well-established modality for treating various urological and musculoskeletal conditions.
- Trial name
- DED-Pilot (NCT07331961)
- Testing
- extracorporeal shock wave therpy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
COPD, Pulmonary Vascular Disorder
Pulmonary Vasculature and Right Heart Dysfunction in Chronic Obstructive Pulmonay Disease
The pulmonary vasculopathy and right heart dysfunction in COPD are drawing increasing attention these days. Recent researches show that pulmonary vasculopathy and right heart dysfunction relate to greater severity in COPD.
- Conditions
- COPD, Pulmonary Vascular Disorder, Right Ventricular Dysfunction
- Trial name
- NCT03184727
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Pelvic Floor Dysfunction; Vaginal Laxity; Bladder Neck Descent in Parous Women
Evaluation of Vaginal Laxity and Bladder Neck Descent in Parous Women Using 2D and 3D Transperineal Ultrasound
This study aims to evaluate vaginal laxity and bladder neck descent in women who have given birth, using non-invasive 2D and 3D transperineal ultrasound.
- Trial name
- VLBNDUS (NCT07491224)
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Assiut University
Obstructive Sleep Apnea, Mild Cognitive Impairment
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometabolic and neurocognitive…
- Conditions
- Obstructive Sleep Apnea, Mild Cognitive Impairment, Subjective Cognitive Impairment
- Trial name
- NCT06089096
- Testing
- Home Sleep Apnea test (HSAT)
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Atherosclerosis, Endothelial Dysfunction
Predictive Medicine Research
To establish normal values by age, race, and gender of novel markers of risk in healthy subjects necessary to predict precise risk of cardiovascular disease in an individual
- Trial name
- NCT00384761
- Where
- United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Emory University
Mild Cognitive Impairment, Dementia
Validation of acceXible's Automated Speech Analysis Method for the Early Detection and Monitoring of Patients With Mild Impairment or Dementia in Primary Care
Dementia, especially dementia caused by Alzheimer's disease, is considered one of the most severe health problems of our time. It is currently known that the disease begins many years before clinical symptoms appear.
- Trial name
- NCT05380297
- Testing
- Speech analysis
- Where
- Spain
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Accexible
Drug Hypersensitivity
Management of Drug Hypersensitivity in Children
The aim of this study is (1) to assess the incidence of suspected drug allergies in a pediatric hospital and the proportion in which these reactions are confirmed to be allergic; (2) to evaluate the diagnostic values of the…
- Trial name
- DHC (NCT02031120)
- Where
- Switzerland
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Mild Cognitive Impairment, The Cognitive Normal Elderly
The Effects of Multidomain Non-pharmacological Interventions on the Elderly With or Without Mild Cognitive Impairment
The study aiming to investigate the efficacy, safety, and potential mechanism of a multimodal intervention on cognitive function in individuals with MCI or the cognitive normal elderly living in a community.
- Trial name
- NCT05483790
- Testing
- the multimodal intervention
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Sleep Apnea, Ventricular Arrythmias
Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias
Hypothesis: The CPAP treatment diminishes the effect of ventricular arrhythmias in patients with ischemic heart disease or dilated myocardiopathy, systolic ventricular disfunction and sleep apnea-hypopnea syndrome…
- Conditions
- Sleep Apnea, Ventricular Arrythmias, Systolic Left Ventricle Dysfunction
- Trial name
- SAHS-ICD (NCT00765713)
- Testing
- Nasal continuous positive airway pressure
- Where
- 3 sites in Spain
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
Cognitive Decline, Mild
Cognition, Flavonoids, Exercise, Gut Microbiome
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants…
- Trial name
- NCT06495190
- Testing
- Blueberry, Walking, Stretching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Erectile Dysfunction
Daily Oral L-arginine Plus Tadalafil in Diabetic Patients With Erectile Dysfunction
Tadalafil is an effective oral therapy in erectile dysfunction. L-arginine is a pro drug that increase the level of nitrous oxide in the smooth muscles so can increase the strength and duration of erection.
- Trial name
- NCT03834610
- Testing
- L-arginine 5 gm oral caps, Tadalafil 10 MG, serum testosterone level
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Adolescent Mental Health, Psychosocial Adaptation
Trauma-Informed School Intervention for Adolescent Mental Health and Self-Injury Prevention in China
This study evaluated a school-based psychosocial adaptive capacity enhancement program for Chinese adolescents. The program was developed to support students who may have experienced childhood household dysfunction or other…
- Conditions
- Adolescent Mental Health, Psychosocial Adaptation, Childhood Household Dysfunction
- Trial name
- TISI-China (NCT07583524)
- Testing
- School-Based Psychosocial Adaptive Capacity Enhancement Program
- Where
- China
- Volunteers
- 5,787 people, healthy volunteers welcome
- Sponsor
- WU Han
Executive Dysfunction, Motor Activity
The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training
This doctoral thesis has the aim to identify the role of Brain-derived neurotropic factor in the relationship between physical fitness/activity and executive functions in typically developing children and children with Autism…
- Conditions
- Executive Dysfunction, Motor Activity, Child
- Trial name
- NCT02503579
- Testing
- physical training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Ghent
Diminished Ovarian Reserve
A Randomized Controlled Trial of Combined Bu Shen Yi Qi Decoction and Dehydroepiandrosterone (DHEA) for the Treatment of Ovarian Function Decline
The purpose of this clinical trial is to evaluate the efficacy and safety of Bushen Yiqi formula combined with dehydroepiandrosterone (DHEA) in the treatment of women with diminished ovarian reserve (DOR).
- Trial name
- NCT07535983
- Testing
- Bushen formula combined with dehydroepiandrosterone
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
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