Clinical trials: Pathophysiology
Abdominal Hypertension, Abdominal Compartment Syndrome
Updated Abdominal Compartment Society Consensus Definitions
An international team of experts is working on a project called updated WSACS consensus definitions. The goals of this study are to: 1. To generate expert consensus on the definitions and classification of IAH and ACS. 2.
- Trial name
- WSACS (NCT07563842)
- Testing
- Delphi study
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Diabetes Mellitus, Type 2
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion
FIERCE is an observational cross-sectional study. Approximately 90 individuals living with type 2 diabetes (T2D) and/or individuals living without diabetes will be randomized (2:1).
- Trial name
- FIERCE (NCT06108388)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Carcinoma, Hepatocellular, Liver Dysfunction
Evaluation of Remnant Liver Function Using Primovist-enhanced MRI Before Resection/Ablation of Hepatocellular Carcinoma
The purpose of this study is to determine whether the global and segmental hepatic uptake and excretion of Gd-EOB-DTPA on Gd-EOB-DTPA-enhanced liver MRI correlates with standard liver function test results in the patients with…
- Trial name
- LiFE (NCT01490203)
- Testing
- Gd-EOB-DTPA, MRI
- Where
- 4 sites in South Korea
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Placental Dysfunction, Prenatal Stress
Effects of Pregnancy-Specific Anxiety on Placental Inflammatory and Oxidative Stress Response and Birth Outcomes
Explore the associations of prenatal maternal anxiety to placental histologic findings, and the pro-inflammatory, anti-inflammatory, and immunoregulatory cells found in the placenta and determine the effect of maternal anxiety on…
- Trial name
- MOMSPlacenta (NCT04993742)
- Testing
- MOMS Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Vocal Cord Dysfunction, Asthma Brittle
Is Laryngeal Ultrasound Useful in the Assessment for ILO? A Protocol for a Two-stage Exploratory Pilot Study
This study is a feasibility study to see if an ultrasound scan of the vocal cords can detect narrowing of the vocal cords as seen in a condition called inducible laryngeal Obstruction (the vocal cords narrow or close on breathing…
- Conditions
- Vocal Cord Dysfunction, Asthma Brittle, Inducible Laryngeal Obstruction, Paradoxical Vocal Fold Motion
- Trial name
- NCT05686941
- Testing
- Trans-cutaneous Laryngeal ultrasound (TLUS), TLUS and simultaneous laryngoscopy
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lancashire Teaching Hospitals NHS Foundation Trust
Vaginal Infection, Vaginal Discharge
Evaluation of a Postcoital Sponge on Self-Reported Vaginal Health Parameters
LiviWell has developed a product designed for postcoital semen absorption. Previous studies have demonstrated the product rapidly absorbs semen, and leads to less symptoms of postcoital vaginal microbiome disruption such as…
- Conditions
- Vaginal Infection, Vaginal Discharge, Vaginosis, Sexual Dysfunction
- Trial name
- NCT06530186
- Testing
- LiviWell Postcoital Vaginal Insert
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Hypertension, Atherosclerosis
Age-Related Changes in Body Composition
Background: Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age.
- Trial name
- NCT01517113
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Migraine
Physiopathology, Diagnosis and Therapy of Primary Cephalalgia and Adaptive Disorders
The main aim of the present pilot study is to prove the possibility to use the Nitroglycerin (NTG) model to describe the pathophysiology of headache using task-free advanced Magnetic Resonance Imaging (MRI) techniques, in order…
- Trial name
- NCT04696510
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Abnormally Decreased Muscle Contraction
Abdominal Wall Evaluation in Low Back Pain
The purpose of this study was to evaluate feed-forward contraction of the transversus abdominis and thickness of the transversus abdominis, obliquus internus, and obliquus externus during calm and standardized respiration in low…
- Trial name
- NCT01488760
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Mild Cognitive Impairment, Dementia
Korean Joint Registry for Alzheimer's Treatment and Diagnostics (JOY-ALZ)
The purpose of this research is to investigate the long-term effectiveness and safety of new Alzheimer's disease treatments, particularly monoclonal antibody therapies like lecanemab and donanemab, as well as to enhance…
- Conditions
- Mild Cognitive Impairment, Dementia, Subjective Cognitive Decline (SCD), Alzheimer Disease
- Trial name
- JOY-ALZ (NCT06889818)
- Where
- 3 sites in South Korea
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Mild Cognitive Impairment
Effects of Alpha-lactalbumin Intake on Metabolic and Cognitive Functions in Elderly
Aging modifies the metabolic pathway of the neurotransmitter serotonin by reducing the synthesis rate and increasing the breakdown rate of serotonin, possibly related to the observed enhanced sensitivity of the serotonergic…
- Trial name
- NCT02082418
- Testing
- Alpha-lactalbumin, Whey, Casein
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Postoperative Cognitive Dysfunction
Risk Factors for Early POCD in the Patients With PSM Undergoing CRS-HIPEC
Objectives to investigate the incidence and associated factors for early postoperative cognitive dysfunction in the patients with peritoneal surface malignancies undergoing cytoreductive surgery and hyperthermic intraperitoneal…
- Trial name
- NCT02462564
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Wuhan University
Cardiovascular Diseases
The STandard Versus ImAging SuBstrate Aided Ablation in Severe Left VEntricular Dysfunction VT.
The STABLE-VT trial aims to determine the safety profile and clinical efficacy of a modified approach to ventricular tachycardia (VT) ablation that integrates myocardial scar as visualized on cardiac magnetic resonance (c-MRI) or…
- Trial name
- STABLE-VT (NCT05828667)
- Testing
- Incorporation of CT and/or c-MRI derived myocardial scar with 3D electroanatomical mapping (EAM).
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Systemic Sclerosis (SSc), Sexual Dysfunctions
Relationship Between Pelvic Floor Dysfunctions and Sexual Dysfunction in Female Patients with Systemic Sclerosis
Relationship Between Pelvic Floor Dysfunctions and Sexual Dysfunction in Female Patients with Systemic Sclerosis
- Conditions
- Systemic Sclerosis (SSc), Sexual Dysfunctions, Pelvic Floor Disorder
- Trial name
- NCT06769399
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4
Physiopathology of Neuromuscular Function Related to Fatigue in Chronic Renal Disease
Chronic Kidney Disease (CKD) induces many metabolic troubles especially for the advanced CKD (stage 3b-5) patients and their prevalence and importance grow with the deterioration of the glomerular filtration rate (GFR).
- Conditions
- Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Fatigue
- Trial name
- PIONEER (NCT04330807)
- Testing
- Handgrip fatigability test, Questionnaires
- Where
- France
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier le Mans
Stroke, Upper Extremity Paresis
Sensory Mechanisms of Manual Dexterity Recovery After Stroke: a Prospective Cohort Study of Prediction and Cerebral Correlates
In the proposed research, we will assess motor and sensory functions of the hand using clinical tests and a tool designed to measure manual dexterity combined with vibrotactile stimulation.
- Conditions
- Stroke, Upper Extremity Paresis, Manual Dexterity, Sensory Integration Dysfunction
- Trial name
- HapticS 2 (NCT07340736)
- Testing
- Haptic stimulation device, Brain MRI
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Skin Barrier to Water Loss, Microbial Colonization
Topical Lactobacillus Crispatus for Skin Barrier Dysfunction in Obesity
This clinical trial aims to evaluate the safety and efficacy of topical application of Lactobacillus crispatuson the forearm for treating obesity-induced skin barrier impairment in individuals aged 18-45 with BMI ≥25.
- Trial name
- NCT07266532
- Testing
- Topical Inactivated Lactobacillus crispatus Application Group, Topical L. crispatus Treatment Group
- Where
- China
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
Cognitive Impairment, Cognitive Decline
Cognitive Screening Made Easy for PCPs - Administrative Supplement
This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care.
- Conditions
- Cognitive Impairment, Cognitive Decline, Dementia, Mild
- Trial name
- NCT06928298
- Testing
- RACS app
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Upper Cross Syndrome, Temporomandibular Disorder (TMD)
Upper Cross Syndrome and Temporomandibular Dysfunction in University Students
This cross-sectional observational study aims to investigate the relationship between Upper Cross Syndrome (UCS), a postural imbalance characterized by forward head posture and rounded shoulders, and Temporomandibular Disorder…
- Trial name
- UCS-TMD (NCT07456748)
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Sacroiliac Dysfunction
Global Changes Associated With Sacroiliac Joint Dysfunction
Summary Sacroiliac joint dysfunction (ASI) is an alteration in the normal biomechanics of the joint, which leads to hypomobility or hypermobility of that joint.
- Trial name
- GCASID (NCT06687148)
- Testing
- Manual manipulation
- Where
- Portugal
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Aveiro University
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