Clinical trials: Pathophysiology
University Students
Temporomandibular Disorders and Balance Performance
This study aims to investigate the relationship of the temporomandibular joint with head posture, pressure pain threshold, and body balance.
- Trial name
- NCT06891859
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Sexual Dysfunction
Female Sexual Dysfunction Intervention
The goal of this psychosocial research study is to learn whether a website program called "Tendrils: Sexual Renewal for Women after Cancer " may help female cancer survivors improve their sex lives when used either as a self-help…
- Trial name
- NCT00614276
- Testing
- Focus Group, TENDRILS, Questionnaires
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Chronic Obstructive Pulmonary Disease
Muscle Dysfunction in Patients With Chronic Obstructive Lung Disease (COPD): the Role of Sympathetic Activation
The objective of the project is to better understand the causes of exercise limitation, dyspnea and neurohumoral activation in patients with COPD.
- Trial name
- NCT01750489
- Testing
- non-invasive ventilation (NIV)
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Spastic Ataxia
Phenotypes, Biomarkers and Pathophysiology in Spastic Ataxias
The aim of this study is to determine the clinical spectrum and natural progression of Spastic Ataxias (SPAX) and related disorders in a prospective multicenter natural history study, identify digital, imaging and molecular…
- Trial name
- SPAX-PBP (NCT04297891)
- Testing
- Clinical rating scale to measure Ataxia disease severity and progression, Clinical rating scale to measure spastic paraplegia disease severity and progression, Disease-specific severity index for adults with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)
- Where
- 9 sites in Canada, France and 5 more
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Dr. Rebecca Schule
Metabolic Dysfunction-steatohepatitis (MASH)
Ultrasound Biomarkers for Assessing Eligibility and Response to Resmetirom Therapy
This is a prospective, non-interventional, observational study to evaluate the accuracy of 2 US (ultrasound) biomarkers that quantify liver tissue fat and stiffness: UDFF (ultrasound-derived fat fraction) and pSWE (point shear…
- Trial name
- NCT07860814
- Where
- 3 sites in United States
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- Radnet Management, Inc.
Chronic Granulomatous Disease, Crohn'S-like IBD
Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease
This study will determine if the drug infliximab is safe for treating inflammatory bowel disease (IBD) in patients with chronic granulomatous disease (CGD).
- Conditions
- Chronic Granulomatous Disease, Crohn'S-like IBD, Inflammatory Bowel Disease (IBD)
- Trial name
- NCT00325078
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mild Cognitive Impairment, Mild Dementia
Gait Analysis by Induced Disorientation in a VR Environment
The aim of the study is to investigate whether the effect of disorientation on physical motion and gait among dementia patients, can be reliably measured in a laboratory environment, by means of a virtual reality (VR)…
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Disorientation, Young Adults
- Trial name
- NCT04134806
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Medical Center Rostock
Peripheral Arterial Disease
The Impact of Branched-Chain Amino Acid Metabolism on Limb Dysfunction in PAD
Test the theory that abnormalities in the large blood vessels that deliver blood to your leg and the very small blood vessels in your leg's muscles (invisible to the eye) work together to worsen your leg function and walking.
- Trial name
- NCT03490968
- Testing
- Supervised Exercise, Vascular Assessment
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Inflammation, Endothelial Dysfunction
Effect of CEAG on Inflammation and Endothelial Function
The purpose of the study is to look at the effect a dietary supplement called CEAG [Curcuminoids, EPA (Omega-3), Astaxanthin and Gamma Linolenic Acid (GLA)] has on inflammation and endothelial (inner layer of the blood vessels)…
- Trial name
- CEAG (NCT03906825)
- Testing
- CEAG
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Preeclampsia, Preeclampsia Postpartum
Vascular Effects of High-Salt After Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT06749418
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG)
A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases
The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.
- Conditions
- Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG), Dry Eye Disease (DED), Keratoconus
- Trial name
- NCT07780890
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment, Alzheimer's Disease
African American Alzheimer's Progression Markers - CSF and Neuro-Imaging
African Americans are twice as likely to develop Alzheimer's disease as white Americans, but few African Americans are enrolled in large Alzheimer's biomarker studies.
- Trial name
- A3PM (NCT02089555)
- Testing
- Lumbar puncture, Blood draw, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Emory University
Alzheimer's Disease, Mild Cognitive Impairment
System-IGF-1 Pathway and Alzheimer's Disease
The aim is to assess the relationship between levels of IGF-I system components and cognitive status in patients with Alzheimer's disease (AD), in elderly subjects with normal cognitive function, and in patients with mild…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Cognitive Function 1, Social, Control With Normal Activities of Daily Living
- Trial name
- SIGAL (NCT00647478)
- Where
- France
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Premature Ejaculation
A Safety and Tolerability Study of Administration of PSD502
A Phase I, Single-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group, Pharmacokinetic and Safety Study to Evaluate Systemic Exposure and Local Vaginal Exposure to Lidocaine and Prilocaine and the Metabolites 2,6…
- Trial name
- NCT01183208
- Testing
- Intervention A, Intervention B, Intervention C
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Plethora Solutions Ltd
Chronic Periodontitis, Prehypertension
Impact of Periodontal Intervention on Vascular Dysfunction
The purpose of this study is to determine the effect of periodontal intervention on vascular dysfunction among Chinese prehypertensive adults with moderate to severe periodontal disease.
- Trial name
- NCT01917292
- Testing
- One-Stage Full-Mouth Disinfection, Periodontal care
- Where
- China
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Chronic Kidney Disease, Acute Kidney Injuries
Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies
Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain.
- Conditions
- Chronic Kidney Disease, Acute Kidney Injuries, Real World Study, Dementia
- Trial name
- NCT07093684
- Testing
- Kidney disease
- Where
- Sweden
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cirrhosis, Cardiomyopathy
Subclinical Myocardial Dysfunction in Patients With Hepatic Cirrhosis
The prevalence of hepatic cirrhosis in Romania is very high, with a 10-year mortality of 34-66%. Upward trend of mortality is observed. It is known that cirrhosis is associated with cardiac abnormalities.
- Trial name
- CIRRHECHO (NCT01713478)
- Testing
- echocardiography
- Where
- Romania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Endothelial Dysfunction
The Cardiovascular Effects of Air Pollution: the Role of Nitric Oxide
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived…
- Trial name
- NCT00845767
- Testing
- Forearm Vascular Study
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Healthy, Cyclists
Effects of Contemporary Cycling Saddle Designs on Penile Transcutaneus Oxygen and Carbon Dioxide Levels in Elite Road Cyclists Riding on a Stationary Trainer
Aim of this research is to compare novel 3D printed cycling saddle with the bestselling saddles from two major cycling manufacturers in terms of effects on penile blood gasses and update these findings on current style of racing…
- Conditions
- Healthy, Cyclists, Blood Gas Monitoring, Transcutaneous, Penile Numbness
- Trial name
- EC-SADDLE (NCT05887193)
- Testing
- Biothesiometry, Transcutaneous blood gas monitoring, Cycling on a home trainer
- Where
- Czechia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Milan Martínek
Occupational Therapy, Nursing Caries
Spanish Adaptation and Validation of the Everyday Cognition Battery (ECB).
HYPOTHESIS: The Spanish version of the Everyday Cognition Battery Scale (ECB) is valid and reliable in the Spanish population. OBJECTIVES: Providing a validated scale in Spanish to evaluate daily cognition in older adults.
- Conditions
- Occupational Therapy, Nursing Caries, Aging Disorder, Cognitive Disorders
- Trial name
- NCT04169633
- Testing
- Cognitive Function Evaluation
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.