Clinical trials: Pathophysiology
Chronic Pancreatitis Pancreatic Exocrine Insufficiency Blood Glucose
A Study on the Changes of Glucose Metabolism and Exocrine Function in Patients With Chronic Pancreatitis
This study aims to investigate the impact of pancreatic exocrine insufficiency on the glucose profile and pancreatic and gastrointestinal endocrine hormones in patients with chronic pancreatitis through pancreatic enzyme…
- Trial name
- NCT07314489
- Testing
- Creon（Pancreatin Enteric-coated Capsules）
- Where
- 2 sites in China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Alzheimer Disease, Mild Cognitive Impairment
The Comparative Effectiveness Dementia & Alzheimer's Registry
To evaluate the effectiveness of using clinical precision medicine to develop lifecourse interventions for Alzheimer's disease (AD) prevention and treatment.
- Trial name
- CEDAR (NCT03687710)
- Testing
- Multidomain precision medicine intervention
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Balloon Eustachian Tuboplasty
The Therapeutic Effect of BET in COM With ETD
Currently, surgical treatment of patients with chronic otitis media is one of the most important treatment methods. However, the current results show that some patients with eustachian tube dysfunction can't reconstruct the…
- Trial name
- NCT03440710
- Testing
- BET
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction
A Study Evaluating an Implantable Cardiac Microcurrent Device in Patients With Chronic Heart Failure
This study evaluates the safety and performance/effectiveness of the C-MIC System, an active implantable medical device designed to treat patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Ischemic and Non-ischemic Cardiomyopathy
- Trial name
- NCT07795359
- Testing
- Subcutaneous cardiac microcurrent treatment
- Volunteers
- 60 people
- Sponsor
- Berlin Heals GmbH
Carotid Stenosis, Mild Cognitive Impairment
Dental Carotid Cognitive Study
Periodontal Disease (PD) is present in 60+% of adults >65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive…
- Conditions
- Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
- Trial name
- NCT03755362
- Testing
- Standard Treatment, Intensive Treatment
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Maryland, Baltimore
Cognitive Decline
A Supplement on Cognitive Function and Brain Activity in Middle Age and Older Healthy Adults
PoZibio™ capsules contains Lactobacillus paracasei which has been heat-killed (post-biotic). The researchers will recruit a cohort of middle aged and older adults (>50 years) who will be randomised into PoZibio™ (2 x capsules…
- Trial name
- PZAC (NCT05892627)
- Testing
- PoZibio
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
COVID-19, Dyspareunia
Postpartum Sexual Function in Pregnant Women With COVID-19
The aim of this study is to identify women with postpartum sexual dysfunction and dyspareunia risk in the early period and to use the treatment and care services they need effectively.
- Conditions
- COVID-19, Dyspareunia, Postpartum Period
- Trial name
- NCT04389489
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Delirium
Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR)
This is a pilot randomized controlled trial that will test whether a multicomponent decision support system will improve the postoperative environment for neurocognitive and clinical recovery in older, high-risk surgical…
- Trial name
- NCT04007523
- Testing
- Family Support System, HELP Support System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Erectile Dysfunction
Low-energy Linear Extracorporal Shock Wave Therapy for Erectile Dysfunction.
The purpose of this study is to determine whether extracorporeal shock wave therapy (ESWT) is an effective treatment for erectile dysfunction.
- Trial name
- ESWTvsED (NCT02063061)
- Testing
- ESWT treatment
- Where
- Denmark
- Volunteers
- 126 people
- Sponsor
- Grzegorz Fojecki
Abdominal Hypertension, Abdominal Compartment Syndrome
Updated Abdominal Compartment Society Consensus Definitions
An international team of experts is working on a project called updated WSACS consensus definitions. The goals of this study are to: 1. To generate expert consensus on the definitions and classification of IAH and ACS. 2.
- Trial name
- WSACS (NCT07563842)
- Testing
- Delphi study
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Intestinal Graft Dysfunction
Endoscopically One-year Follow-up in Patients After Small-bowel Transplantation
Intestinal transplantation is associated with high numbers of ejection events. A close endoscopic controll of the intestinal graft is possible. Sasaki et al.
- Trial name
- NCT04633486
- Testing
- zoom-endoscopy
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital Tuebingen
Shock, Septic, Pituitary Dysfunction
Pituitary Function After Recovery From Septic Shock Among ICU Survivors
Prolonged circulatory shock is associated with marked disturbances in vascular supply to the brain, and endothelial dysfunction which can lead to disseminated intravascular coagulation and microvascular thrombosis.
- Conditions
- Shock, Septic, Pituitary Dysfunction, Hypopituitarism
- Trial name
- NCT05990491
- Where
- 2 sites in India
- Volunteers
- 90 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
AV Block
Left Septal Pacing or Left Bundle Branch Pacing to Avoid Left Ventricle Systolic Dysfunction
Right ventricular apical pacing (RVAP) can produce left ventricular dysfunction (LVD). Conduction system pacing (CSP) has been used successfully to reverse LVD in patients with left bundle branch block.
- Trial name
- STAY II (NCT06707662)
- Testing
- Pacemaker and defibrillator
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Parc de Salut Mar
Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment
Prognosis and Diagnosis of Acute Gastrointestinal Dysfunction in Cardiac Surgery Patients
The purpose of this prospective observational clinical cohort study is to develop a scientifically based approach to the prediction and early diagnosis of intestinal dysfunction in cardiac surgery patients.
- Conditions
- Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment, Cardiac Surgery, Cardiac Surgery in Adult Patient
- Trial name
- PREDICT-GICS (NCT07422246)
- Testing
- additional blood testing for specific and non-specific markers of intestinal dysfunction, ultrasound examination of abdominal organs and measurement of intra-abdominal pressure
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Autonomic Dysfunction, Orthostatic Intolerance
Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study
Observational two phase, retrospective and prospective registry study to assess the prevalence of and characterize outcomes of autonomic dysfunction (AD) in patients who undergo bariatric surgery (BS) and to better define the…
- Trial name
- NCT06289413
- Testing
- Development of AD/OI after BS
- Where
- 8 sites in United States
- Volunteers
- 400 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Dysfunction; Endocrine, Effects of Chemotherapy
Blood Spot Self-administered Test and Assay
The current study will compare hormone levels of AMH, FSH and inhibin B in blood specimens collected by venipuncture and fingerstick in a sample of pre-menopausal women ages 18-45 years with normal menstrual cycles.
- Conditions
- Dysfunction; Endocrine, Effects of Chemotherapy, Premature Ovarian Failure
- Trial name
- NCT03840824
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Erectile Dysfunction
A Study to Evaluate the Safety and Effectiveness of Mirodenafil in Korean Patients With Erectile Dysfunction
The purpose of this study is to evaluate the safety and effectiveness of mirodenafil in participants with erectile dysfunction.
- Trial name
- NCT01802359
- Testing
- No intervention
- Volunteers
- 379 people
- Sponsor
- Janssen Korea, Ltd., Korea
Alzheimer Disease, Dementia Alzheimers
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
This project's main goal is to use state-of-the-art passive sensing techniques to identify digital biomarkers that relate to bioenergetic changes in the brain due to nicotinamide riboside supplementation in those with mild…
- Conditions
- Alzheimer Disease, Dementia Alzheimers, Dementia, Cognitive Impairment
- Trial name
- Emerald-NRAD (NCT05245903)
- Testing
- Emerald Device Monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
End Stage Renal Failure, Hemodialysis
Catheters Dysfunction Rate After Instillation of Ethanol 60% Lock Solution in Tunneled Silicone Catheter of Chronic Hemodialysis Patients
The primary objective of the study is to examine the risk of catheter dysfunction during the dialysis session that follows the instillation of ethanol 60% as lock solution in tunneled silicone catheters of end stage renal failure…
- Trial name
- Ethanol (NCT00563342)
- Testing
- Ethanol
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Vaginismus, Sexual Dysfunctions
Evaluation and Comparison of Women Pelvic Floor With and Without Sexual Dysfunction (Vaginismus)
Sexuality is considered one of the pillars of quality of life, an integral part of the personality of each individual. Being a basic human being need, it cannot be separated from other aspects of life.
- Conditions
- Vaginismus, Sexual Dysfunctions, Muscular Hypertonicity, Muscle Tone Poor
- Trial name
- NCT03176069
- Testing
- Evaluation and Comparison of women pelvic floor with and without sexual dysfunction, The physiotherapeutic treatment
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
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