Clinical trials: Patient With Colorectal Cancer
Colorectal Cancer
Phase I Trial of huA33 Plus Chemotherapy in Patients With Metastatic Colorectal Cancer
Although treatment for metastatic colorectal cancer has improved significantly over the recent years, it still remains a significant health problem representing the leading cancer by incidence in the United States of America.
- Trial name
- NCT00199797
- Testing
- Oxaliplatin, 5-Fluorouracil, Leucovorin
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 20 people
- Sponsor
- Ludwig Institute for Cancer Research
Solid Tumor
A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors
This is a first in human, single arm, open label, Phase 1a/1b study to determine the safety, feasibility, and efficacy of a single dose of NeoTCR-P1 T cells in participants with solid tumors.
- Trial name
- NCT03970382
- Testing
- NeoTCR-P1 adoptive cell therapy, nivolumab, IL-2
- Where
- 9 sites in United States
- Volunteers
- 21 people
- Sponsor
- PACT Pharma, Inc.
Colorectal Cancer Metastatic
Nab-Sirolimus in Combination With FOLFOX & BEV as 1st Line Therapy in Patients With Advanced or Metastatic Colorectal Cancer
A phase 1/2 multi-center investigation of nab-sirolimus (also known as ABI-009, nab-rapamycin) in combination with mFOLFOX6 and Bevacizumab as first-line therapy in patients with metastatic colorectal cancer
- Trial name
- NCT03439462
- Testing
- nab-sirolimus
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Aadi Bioscience, Inc.
Advanced Solid Tumors
Safety and Efficacy Study of PRI-724 in Subjects With Advanced Solid Tumors
PRI-724 is a new investigational drug being studied to treat subjects with cancer who have advanced solid tumors. PRI-724 is thought to work by blocking the Wnt signaling pathway that cancer cells need to grow and…
- Trial name
- NCT01302405
- Testing
- PRI-724
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Prism Pharma Co., Ltd.
Colon Cancer
Herbal Treatment to Improve Chemotherapy Delivery
This study is designed to:(1) determine the efficacy of Traditional Chinese Medicine (TCM) 'Tonifying Spleen and Kidney Sequential Regimen' (TSKSR) in improving the completion rate of 8-cycle CapeOX chemotherapy in patients with…
- Trial name
- HATCHED (NCT03716518)
- Testing
- Tonifying Spleen and Kidney Sequential Regimen
- Where
- 12 sites in China
- Volunteers
- 400 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Oncology, Chemotherapy-Induced Peripheral Neuropathy
8 Weeks vs 12 Weeks Physical Exercise Programmes in Colorectal Cancer Patients
Chemotherapy is a cornerstone in the treatment of colon cancer; however, its effects extend beyond malignant cells. Because chemotherapeutic agents target rapidly dividing cells, they can also damage healthy tissues, resulting in…
- Trial name
- NCT07307690
- Testing
- Exercise, Physical activity recommendations
- Volunteers
- 50 people
- Sponsor
- University of Salamanca
Rectal Cancer
DETECT: Target Volume for Rectal Endoluminal Radiation Boosting
The aim of the study is to provide prospective data regarding microscopic tumor spread in all directions from the macroscopic tumor in pathology specimens, as seen by eye, and on imaging to define the target volume for…
- Trial name
- DETECT (NCT04927897)
- Testing
- Ultrasound, Rectoscopy, Scan, e.g. CT (resection specimen)
- Where
- 3 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht Radiation Oncology
Colorectal Neoplasms
Safety Study of Regorafenib and SIR-Spheres® Microspheres Radioembolization in Patients With Refractory Metastatic Colorectal Cancer With Liver Metastases
The purpose of this study is to determine the safety of regorafenib, an antiangiogenic drug, when combined with radioembolization using SIR-Spheres® microspheres in the treatment of colorectal cancer (CRC) that has spread to the…
- Trial name
- NCT02195011
- Testing
- SIR-Spheres, Regorafenib
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- SCRI Development Innovations, LLC
ColoRectal Cancer Screening
Patient Navigation for Colorectal Cancer Screening for Patients With Mental Illness and/or Substance Use Disorder
The investigators propose to develop, implement, and evaluate a novel Colorectal (CRC) screening patient navigator program for patients with Mental Health (MH) and /or Substance Use Disorder (SUD) receiving care at Massachusetts…
- Trial name
- NCT03244787
- Testing
- patient navigation
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer, Type 2 Diabetes
Impact of Colorectal Cancer and Nutrition Education Program Among Minority Patients With Type 2 Diabetes
The goal of this observation study is to deliver an education program designed to increase knowledge of colorectal cancer prevention and nutrition education in minorities with Type 2 diabetes.
- Trial name
- NCT05765214
- Testing
- Intervention Group (IG)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
Cancer, PDAC
A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors
This study is an investigation to evaluate the safety/tolerability, pharmacokinetics (PK), and efficacy of GFH276 as a single agent in patients with advanced solid tumors harboring RAS mutations.
- Conditions
- Cancer, PDAC, CRC (Colorectal Cancer), NSCLC
- Trial name
- NCT07198321
- Testing
- GFH276
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Genfleet Therapeutics (Shanghai) Inc.
Colorectal Cancer Stage III, Adjuvant Chemotherapy
SOX Versus XELOX as Adjuvant Chemotherapy for Stage III Colorectal Cancer Patients
Fluorouracil combined with oxaliplatin are routinely recommended to patients with pathological stage III (p-stage III) colorectal cancer, leading to significant improvement of 5-year disease-free survival and overall survival…
- Trial name
- NCT03448549
- Testing
- Oxaliplatin, Tegafur，gimeracil and oteracil potassium, Xeloda
- Where
- China
- Volunteers
- 1,191 people
- Sponsor
- Peking University Cancer Hospital & Institute
Gastric Cancer, Hepatocellular Carcinoma
Personalized DC Vaccine for Postoperative Cancer
The study is aimed to the test efficacy and safety of neoantigen-primed dendritic cell (DC) cell vaccine therapy for postoperative locally advanced gastric cancer, hepatocellular carcinoma, lung cancer and colorectal cancer, and…
- Conditions
- Gastric Cancer, Hepatocellular Carcinoma, Non-Small-Cell Lung Cancer, Colon Rectal Cancer
- Trial name
- NCT04147078
- Testing
- DC vaccine subcutaneous administration
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sichuan University
Recurrent Colon Cancer, Recurrent Rectal Cancer
PET-MRI in Diagnosing Patients With Colon or Rectal Cancer
This pilot clinical trial studies positron emission tomography (PET)-magnetic resonance imaging (MRI) and PET-computed tomography (CT) as diagnostic imaging in patients with colon and/or rectal cancer.
- Conditions
- Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IIA Colon Cancer, Stage IIA Rectal Cancer
- Trial name
- NCT01807117
- Testing
- positron emission tomography, computed tomography, magnetic resonance imaging
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Case Comprehensive Cancer Center
Colorectal Cancer, Non Resectable Metastasis
Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate Synthase
The aim of the study was to evaluate the feasibility of TS determination in a multicenter trial setting using a central facility for measurement and confirm its role as predictive factor for 5-FU treatment in MCRC.
- Conditions
- Colorectal Cancer, Non Resectable Metastasis, Reference Lesion, Biopsy
- Trial name
- FOGT5 (NCT01212718)
- Testing
- FUFA, systemic chemotherapy
- Where
- Germany
- Volunteers
- 168 people
- Sponsor
- University of Ulm
Rectal Cancer, Gastric Cancer
The Effect of Bone Marrow-sparing Intensity-Modulated Radiotherapy to GI Cancer
Concurrent chemotherapy with external beam radiotherapy is the standard treatment of bulky or locally advanced cervical cancer, gastric cancer and rectal cancer.Despite excellent therapeutic results, acute hematologic toxicity…
- Conditions
- Rectal Cancer, Gastric Cancer, Bone Marrow Toxicity, Adverse Effect of Radiation Therapy
- Trial name
- IMRT (NCT01863420)
- Testing
- Bone Marrow-sparing Intensity-Modulated Radiotherapy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Chinese Academy of Medical Sciences
Metastatic Colon Cancer
ZETA : Prospective Observational Study
Primary objective Evaluate the efficacy in terms of progression-free survival (PFS) of aflibercept in combination with FOLFIRI in patients treated routinely for metastatic colorectal cancer (mCRC) after failure of treatment with…
- Trial name
- ZETA (NCT03730558)
- Testing
- aflibercept + FOLFIRI
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Recherche clinique
Colorectal Cancer, Neoplasm Metastasis
Proof-of-concept Study of Blood Markers of Tumor Dissemination in Patients With Versus Without Intestinal Polyps
The study authors hypothesize that in patients with intestinal polyps, tumor cells could disseminate and circulating factors could be secreted by the polyp.
- Conditions
- Colorectal Cancer, Neoplasm Metastasis, Disseminated Cancer
- Trial name
- EARDIS (NCT05648240)
- Testing
- Blood test
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
HNSCC, Melanoma
Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors
The subject of this study is the adoptive transfer of selected autologous tumor infiltrating lymphocytes (TIL) after in vitro expansion for the treatment of solid tumor malignancies.
- Conditions
- HNSCC, Melanoma, Gynecologic Cancer, Colorectal Cancer
- Trial name
- ACT (NCT05902520)
- Testing
- DP CD8 TIL, DP CD8 TIL KD, Low dose IL-2
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- AgonOx, Inc.
Colorectal Cancer Metastatic
Improving SUrgery of Liver Metastases: a Trial of the Arterial Chemotherapy Network
National trial, multicenter, randomized, phase II comparing treatment intensification with hepatic arterial infusion chemotherapy plus systemic chemotherapy (CT) to systemic chemotherapy alone in patients with liver-only…
- Trial name
- SULTAN (NCT03164655)
- Testing
- Oxaliplatin, Cetuximab, Bevacizumab, Panitumumab, Irinotecan, Leucovorin, 5-Fluorouracil
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- UNICANCER
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.