Clinical trials: Patients Undergoing Laparoscopic Surgery
Postoperative Pulmonary Complications, Positive End-expiratory Pressure
Individualized PEEP Titration on Postoperative Pulmonary Complications
This study aims to investigate the effectiveness and safety of implementing a personalized positive end-expiratory pressure (PEEP) management strategy guided by esophageal pressure (Pes), as well as its potential to reduce the…
- Conditions
- Postoperative Pulmonary Complications, Positive End-expiratory Pressure, Elderly, Laparoscopic Surgery
- Trial name
- NCT06150079
- Testing
- Pes-Guided PEEP titration
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Zhongshan Hospital
Pulmonary Atelectasis, Postoperative
Individual Optimal Positive End-expiratory Pressure During Robot-assisted Laparoscopic Radical Prostatectomy
During robot-assisted radical prostatectomy, pneumoperitoneum with Trendelenburg position is used. However, perioperative atelectasis and respiratory complications may occur with high incidence due to general anesthesia and…
- Trial name
- NCT04085146
- Testing
- Individualized optimal positive end-expiratory pressure, Conventional positive end-expiratory pressure
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs)
EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery
This study is a prospective, single-center, single-blind, randomized controlled clinical trial. Patients scheduled for laparoscopic bariatric surgery will be selected and randomly assigned to either the EIT-guided individualized…
- Conditions
- Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs), Recruitment, Mechanical Ventilation Complication
- Trial name
- EIT (NCT07207772)
- Testing
- Group P-eit, Group P-8
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Jianbo Wu
Uterus Myoma, Uterine Cancer
Effect of Anesthetic Agents on Optic Nerve Sheath Diameter
The present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.
- Trial name
- NCT03701529
- Testing
- Sevoflurane, Propofol
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Anesthesia, Mechanical Ventilation
VC-AF vs FCV in Obese Patients Undergoing Laparoscopic Surgery
Obesity adversely affects respiratory physiology by reducing lung volumes and compliance and increasing airway resistance and alveolar collapse.
- Conditions
- Anesthesia, Mechanical Ventilation, Obesity
- Trial name
- NCT07875530
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Postoperative Pain
Transversus Abdominis Plane (TAP) Block Laparoscopic Hysterectomy
The transversus abdominis plane (TAP) block involves the sensory nerve supply of the anterior -lateral abdominal wall where the T7-12 intercostal nerves, ilioinguinal, iliohypogastric and the lateral cutaneous branches of the…
- Trial name
- TAP HYS (NCT01074229)
- Testing
- Drug .5% Ropivacaine, 20 cc of 0.25% ropivacaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Northwestern University
Obesity (BMI>30), Postoperative Cognitive Function
Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients
Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial.
- Trial name
- NCT07665645
- Testing
- Sevoflurane (Volatile Anesthetic), propofol, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Laparoscopic Surgery for Cholecystitis
Clinical Study on the Effect of Tegileridine on Postoperative Pain in Patients Undergoing Abdominal Surgery.
This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of tegileridine fumarate injection for postoperative analgesia in adults experiencing moderate-to-severe pain after abdominal surgery.
- Trial name
- NCT07277153
- Testing
- Tegileridine (tegileridine fumarate injection, IV), 0.9% Normal Saline (0.9% Sodium Chloride) injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xin Chen
Peripheral Neuropathy, Intraoperative Injury
Steep Trendelenburg With or Without Lithotomy Positioning on the Operating Table.
Robotic assisted laparoscopic and laparoscopic gynecological, colon-rectal and urological surgical procedures require that patients be placed in steep Trendelenburg positioning with or without lithotomy on operating table.
- Conditions
- Peripheral Neuropathy, Intraoperative Injury, Intraoperative Complications, Patient Positioning
- Trial name
- NCT05237700
- Testing
- Patient positioning on operating table
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Appendicitis, Surgery
Sugammadex vs Neostigmine Reversal in Pediatric Appendectomy
This study is designed as a randomized controlled trial with patients assigned to neuromuscular reversal with either sugammadex or neostigmine/glycopyrrolate reversal.
- Trial name
- NCT05256901
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
PONV
Amisulpride Injection for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
This study is a randomized controlled clinical trial focusing on the prevention of postoperative nausea and vomiting (PONV), planned to start in May 2026 and end in April 2027.
- Trial name
- NCT07891312
- Testing
- Amisulpride, Ondansetron
- Volunteers
- 718 people
- Sponsor
- Qianfoshan Hospital
Gastroesophageal Junction Adenocarcinoma, Surgery
Gastric Microperfusion in Patients Undergoing Gastroesophageal Resections
Gastroesophageal resection because of gastroesophageal junction (GEJ) adenocarcinoma is a massive surgical intervention. Currently, gastroesophageal cancer surgery is performed with upper laparotomy followed by thoracotomy at the…
- Trial name
- NCT02077673
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cholecystectomy, Laparoscopic
THE RELATIONSHIP BETWEEN PAIN ANXIETY AND POST-OPERATIVE PAIN IN PATIENTS UNDERGOING CHOLECYSTECTOMY SURGERY
This descriptive observational study aims to examine the relationship between preoperative fear of postoperative pain and postoperative pain intensity in patients undergoing cholecystectomy.
- Trial name
- NCT07457905
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Okan University
Cholelithiases, Nursing Caries
The Effect of Early Mobilization and Fluid Consumption on Bowel Movements After Cholecystectomy
Objective: The aim of this study was to determine the effect of early mobilization with consumption of tea, coffee, and warm water on bowel movements in patients who had laparoscopic cholecystectomy surgery.
- Conditions
- Cholelithiases, Nursing Caries, Perioperative Complication, Bowel Ileus
- Trial name
- NCT05800886
- Testing
- Early mobilization and tea consumption, Early mobilization and coffee consumption, Early mobilization and warm water consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Gazi University
Anesthetics, Intravenous, Postoperative Complications
Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery
Ciprofol is a novel 2,6-disubstituted phenol derivatives and is proved have much higher potency and tighter binding toward ɣ-aminobutyric acid type A (GABAA) receptor while maintaining a fast on-set and recovery time compared to…
- Conditions
- Anesthetics, Intravenous, Postoperative Complications, Hypnotics and Sedatives, Postoperative Recovery
- Trial name
- NCT05843383
- Testing
- Ciprofol, Propofol
- Where
- 2 sites in China
- Volunteers
- 280 people
- Sponsor
- Xijing Hospital
Brain Damage, Postoperative
Evaluation of Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With Biomarkers
Robotic assisted laparoscopic surgery has become an alternative to open or laparoscopic technique in various surgical fields. Robot assisted laparoscopic surgery is preferred by surgeons and patients due to easy accessibility…
- Conditions
- Brain Damage, Postoperative, Surgery-Complications
- Trial name
- NCT05692804
- Testing
- Mini Mental State Examination(MMSE),Montreal Cognitive Assessment ( MoCA),S100B ( protein S100 subunit beta) ,GFAP ( glial fibrillary acidic protein ),NSE ( neuron-specific enolase )
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Anaesthesia
Comparison of Laryngeal Mask Airway Supreme and Endotracheal Tube In Patients Undergoing Gynecological Laparoscopy Surgery
Endotracheal Tube (ETT) is still preferred for laparoscopic surgeries because of the fear of pulmonary aspiration and inadequate ventilation.
- Trial name
- NCT02127632
- Testing
- Endotracheal Tube, Laryngeal Mask Airway-Supreme
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dokuz Eylul University
Post Operative Nausea and Vomiting (PONV)
Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients at High Risk for Nausea and Vomiting Undergoing Gynecological Surgery
Amisulpride is a potent antagonist of dopamine D2 and D3 receptors, both implicated in the emetic response when activated. It is currently used intravenously for the prevention of chemotherapy-induced and postoperative nausea and…
- Trial name
- NCT06887621
- Testing
- Encapsulated amisulpride 50 mg (matched for color, weight, smell and size)
- Where
- Brazil
- Volunteers
- 276 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Laparoscopy, Airway Management
Ambu AuraGain vs LMA Supreme in Laparoscopic Surgery
The aim of the study is to compare the performance of two supraglottic airway devices (SGA), the new Ambu AuraGain and the LMA Supreme, in sixty female patients undergoing gynaecologic laparoscopy in the trendelemburg position.
- Conditions
- Laparoscopy, Airway Management, Supraglottic Airway Devices
- Trial name
- NCT02511652
- Testing
- Ambu AuraGain evaluation, LMA Supreme evaluation, Laparoscopic surgery
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Clinic of Barcelona
Intraoperative Hypotension
Internal Jugular Vein Collapsibility Index as a Predictor of Hypotension
The internal jugular vein (IJV) collapsibility index has been proposed as a practical alternative of of the inferior vena cava collapsibility index (IVC-CI), as it is easily accessible using bedside ultrasonography.
- Trial name
- NCT07692425
- Testing
- Internal Jugular Vein Collapsibility Index
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University