Clinical trials: Patients With Cancer
Pancreatic Cancer
Pemetrexed, Gemcitabine, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer
RATIONALE: Pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for their growth. Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either…
- Trial name
- NCT00310050
- Testing
- pemetrexed disodium, Radiotherapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Wake Forest University Health Sciences
Explore Whether lncRNA-ElNAT1 in Urine Exosomes Can be Used as a New Target for Preoperative Diagnosis of Lymph Node Metastasis
A Prospective, Multicenter Cohort Study of Urinary Exosome lncRNAs for Preoperative Diagnosis of Lymphatic Metastasis in Patients With Bladder Cancer
Bladder cancer is one of the most frequent malignant tumors of the urinary system in China, seriously threatening the life safety of patients.
- Trial name
- NCT05270174
- Testing
- no intervention
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Non Small Cell Lung Cancer
A Study of Alimta/Cisplatin/Gefitinib for Asian Non-smoking Participants With Non Small Cell Lung Cancer
The purpose of this study is to compare two different approaches to treating non-small cell lung cancer (NSCLC) in East Asian never-smoker participants.
- Trial name
- NCT01017874
- Testing
- Pemetrexed, Cisplatin, Gefitinib
- Where
- 12 sites in Hong Kong, Singapore and 3 more
- Volunteers
- 236 people
- Sponsor
- Eli Lilly and Company
Relapsed/Refractory Lymphoma
A Study of Tazemetostat in Combination With HMPL-689 in Patients With Relapsed/Refractory Lymphoma
A phase II clinical study of tazemetostat combined with HMPL-689 in patients with R/R lymphoma. The study includes 2 phases: dose escalation phase (phase IIa) and expansion phase (phase IIb).
- Trial name
- NCT05713110
- Testing
- tazemetostat, HMPL-689
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Hutchmed
Acute Myeloid Leukemia
A Phase I Study Investigating the Combination of the Menin Inhibitor Ziftomenib With Venetoclax and Gemtuzumab in Pediatric Patients With Acute Myeloid Leukemia
To find the recommended dose of ziftomenib in combination with gemtuzumab ozogamicin and venetoclax that can be given to pediatric participants who have relapsed or refractory AML or MPAL.
- Trial name
- NCT06448013
- Testing
- Venetoclax, Gemtuzumab, Ziftomenib
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Renal Cancer Metastatic
Nivolumab Plus Stereotactic Body Radiotherapy in II and III Line of Patients With Metastatic Renal Cell Carcinoma
NIVES study is an ongoing phase II, single arm, multicenter study. In this trial pts received SBRT to one non-brain measurable lesion and concomitant NIVOLUMAB, an anti-programmed cell death (PD-1).
- Trial name
- NIVES (NCT03469713)
- Testing
- Nivolumab
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- Gruppo Oncologico Italiano di Ricerca Clinica
Breast Cancer
Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride and genistein, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00244933
- Testing
- genistein, gemcitabine, Tumor biopsy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Solid Tumor
Neo-T in Treating Patients With Advanced Solid Tumors(GI-NeoT-03)
The primary objective of this study is to evaluate the safety of Neo-T in combination with anti-PD1 in patients with solid tumors.
- Trial name
- NCT05798533
- Testing
- Neo-T, Toripalimab, Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- BGI, China
Malignant Solid Neoplasm
Liposomal Irinotecan and Veliparib in Treating Patients With Solid Tumors
This phase I trial studies the side effects and best dose of veliparib when given together with liposomal irinotecan in treating patients with solid tumors.
- Trial name
- NCT02631733
- Testing
- Ferumoxytol, Irinotecan Sucrosofate, Laboratory Biomarker Analysis
- Where
- 6 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
MET Positive, Recurrent Squamous Cell Lung Carcinoma
Lung-MAP: Rilotumumab and Erlotinib Hydrochloride or Erlotinib Hydrochloride Alone as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches
This randomized phase II/III compares rilotumumab when given together with erlotinib hydrochloride against erlotinib hydrochloride alone in treating patients with stage IV squamous cell lung cancer that has come back after…
- Conditions
- MET Positive, Recurrent Squamous Cell Lung Carcinoma, Stage IV Squamous Cell Lung Carcinoma AJCC v7
- Trial name
- NCT02926638
- Testing
- Erlotinib Hydrochloride, Laboratory Biomarker Analysis, Rilotumumab
- Where
- 627 sites in United States
- Volunteers
- 9 people
- Sponsor
- SWOG Cancer Research Network
Moderate to Severe Cancer Pain
Effects of Opioid Drugs on Sleep and Emotion in Patients With Moderate to Severe Cancer Pain
This study is a multicenter cross-sectional observational study, aiming to include approximately 200 patients aged 18-75 years who are using hydrocodone sustained-release tablets or oxycodone sustained-release tablets for pain…
- Trial name
- NCT07616648
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Neoplasms
A Multiple Ascending Dose Study of R1530 in Patients With Advanced Solid Tumors.
This study will determine the maximum tolerated dose, and assess the safety, tolerability and pharmacokinetics of R1530 administered orally to patients with advanced or metastatic solid tumors.
- Trial name
- NCT00493155
- Testing
- RG1530
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Hoffmann-La Roche
Carcinoma, Hepatocellular
Phase II Study of Avelumab in Patients With Advanced Hepatocellular Carcinoma After Prior Sorafenib Treatment
An open label, single arm, Phase II study of avelumab in patients with advanced hepatocellular carcinoma after prior sorafenib treatment
- Trial name
- AvelumabHCC (NCT03389126)
- Testing
- Avelumab
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Waldenstrom's Macroglobulinemia
Study of the Combination of Bortezomib, Dexamethasone, and Rituximab in Patients With Waldenstroms Macroglobulinemia
The purpose of this study is to find out if the combination of bortezomib (Velcade), dexamethasone (Decadron) and rituximab (Rituxan) is effective in treating Waldenstrom's macroglobulinemia.
- Trial name
- NCT00250926
- Testing
- Bortezomib, Dexamethasone, Rituximab
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer Female
Cosmetic Outcome, Patient-reported Outcomes, and Reconstruction-related Complications in Breast Cancer Women Treated With or Without Post-mastectomy Radiation Therapy
This study aim to investigate the breast reconstruction outcome after mastectomy with or without radiation therapy from the patient's point of view.
- Trial name
- NCT03523078
- Testing
- Breast reconstructive surgery
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Yonsei University
Colorectal Cancer, Peritoneal Carcinomatosis
Near-Infrared Imaging of Peritoneal Carcinomatosis From Colorectal Cancer
The purpose of this study is to determine if Near-Infrared fluorescence imaging is an effective approach to detect the colorectal tumoral tissues and peritoneal implants in colorectal cancer patients.
- Trial name
- OC-AP-ICG-IV (NCT02032485)
- Testing
- Indocyanine Green
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Jules Bordet Institute
Oropharynx Cancer
Staying Connected: a Mobile Health Study With the Noona® and Mobili-T® Systems
Mobile health applications are an attractive technological solution that facilitates access to care for patients conveniently and efficiently.
- Trial name
- NCT05368025
- Testing
- Mobili-T/Noona
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University of Alberta
Multiple Myeloma
A Phase II Study of Belinostat in Combination With Bortezomib in Patients With Relapsed, Refractory Multiple Myeloma
This open-label study will assess anti-tumor activity and safety of belinostat in combination with bortezomib (Velcade®) in multiple myeloma patients refractory to or relapsed from at least one prior bortezomib-containing…
- Trial name
- NCT00431340
- Testing
- PXD101
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Valerio Therapeutics
Colorectal Cancer, Colorectal Adenoma
Molecular Imaging of Epidermal Growth Factor Receptor in Colorectal Neoplasia Using Confocal Laser Endomicroscopy
The study aims to: 1. Achieve molecular imaging of EGFR in patients with colorectal neoplasia in vivo using confocal laser endomicroscopy. 2.
- Trial name
- NCT01372189
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shandong University
COVID-19 Vaccine, Cancer
Host Immune Response to Novel RNA COVID-19 Vaccination
To determine the antibody response level in patients with cancer to the COVID-19 vaccination.
- Trial name
- NCT04784689
- Testing
- COVID-19 Vaccine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
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