Clinical trials: Patients With Rectal Cancer
CRC (Colorectal Cancer)
Study of Ruxolitinib in Colorectal Cancer Patients
The purpose of this study was to determine if ruxolitinib, in combination with regorafenib, is safe and effective in the treatment of metastatic colorectal cancer.
- Trial name
- NCT02119676
- Testing
- Ruxolitinib, Regorafenib
- Where
- 86 sites in United States, Australia and 6 more
- Volunteers
- 396 people
- Sponsor
- Incyte Corporation
Neoplasm, Colorectal Cancer
Bevacizumab-containing Regimen for Metastatic Colorectal Cancer Failed to Cytotoxic Treatment
Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), combined with fluoropyrimidine-based chemotherapy is now the standard first and second-line treatment for metastatic colorectal…
- Conditions
- Neoplasm, Colorectal Cancer, Metastatic Neoplasm
- Trial name
- BATTLE (NCT02226289)
- Testing
- Bevacizumab
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Solid Organ Cancers
GL-ONC1 Administered Intravenously Prior to Surgery to Patients With Solid Organ Cancers
The purpose of this study is to evaluate the safety of the investigational product GL-ONC1. GL-ONC1, a vaccinia virus, has been genetically modified for use as a potential anti-cancer drug to destroy cancer cells.
- Trial name
- NCT02714374
- Testing
- GL-ONC1
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Andrew Lowy
Rectal Cancer
An RCT for the Effect of Biofeedback Therapy the Prevention of AR Syndrome in Rectal Cancer Patients
In patients who underwent sphincter preserving surgery with toal mesorectal excision and diverting stoma after neoadjuvant chemoradiation therapy for rectal cancer, the inestigators would evaluate the effect of a biofeedback…
- Trial name
- NCT01661829
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- The Catholic University of Korea
Rectal Cancer, Comorbidities and Coexisting Conditions
Watch and Wait Management on Rectal Cancer Patients Using New Swift Local Therapy
Within our institution, the principal investigator have acquired expertise in endorectal brachytherapy, a localized treatment for colorectal cancer.
- Conditions
- Rectal Cancer, Comorbidities and Coexisting Conditions, Inoperable Disease, Brachytherapy
- Trial name
- Whistle (NCT04336202)
- Testing
- External beam radiotherapy + Endorectal brachytherapy
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Exercise, Total Neoadjuvant Treatment
Study of Daily Step Count and Treatment Response in Rectal Cancer (STEP-R)
This study aims to examine the impact of daily physical activity, specifically step count, on treatment outcomes and side effects in patients with locally advanced rectal cancer receiving total neoadjuvant therapy (chemotherapy…
- Conditions
- Exercise, Total Neoadjuvant Treatment, Rectal Tumors, Smart Watch
- Trial name
- STEP-R (NCT06668402)
- Testing
- Utilizing a smartwatch to gather data on individuals receiving treatment for rectal neoplasm.
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Gazi University
Colorectal Cancer
Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and combining radiation therapy with chemotherapy may kill more tumor cells.
- Trial name
- NCT00002801
- Testing
- leucovorin calcium, tegafur-uracil, radiation therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colon Cancer, Rectum Cancer
Evaluating Factors Affecting Survival in Colon and Rectum Cancer
Colorectal cancers are frequent among cancers of the gastrointestinal system. Whether there are any differences between survival in rectum and colon cancer patients is controversial.
- Trial name
- NCT05388513
- Testing
- Surgical Resection
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Umraniye Education and Research Hospital
Colorectal Cancer, Liver Metastases
The Prediction Model of Avastin Plus Chemotherapy in Unresectable Ras Mutant CRLM Patients
establishment and validation of the prediction model of avastin plus chemotherapy as first line treatment in simultaneous ras mutant unresectable CRLM patients
- Trial name
- NCT04525313
- Volunteers
- 116 people
- Sponsor
- Fudan University
Rectal Cancer
"Watch and Wait" After Neo-adjuvant Chemoradiotherapy for Primary Locally Advanced Rectal Cancer.
Among patients treated for locally advanced rectal cancer with neo-adjuvant radio-chemotherapy, about 15% will have complete clinical response in terms of no visible tumor or ulcerations on the site of the primary tumor, or…
- Trial name
- NORWAIT (NCT03402477)
- Where
- 7 sites in Norway
- Volunteers
- 86 people
- Sponsor
- Helse Stavanger HF
Colorectal Carcinoma
Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in Patients With Colorectal Carcinoma
RATIONALE: Monoclonal antibodies, such as Cetuximab, can target tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.This is an anti-cancer drug which has already been approved…
- Trial name
- NCT00725400
- Testing
- Cetuximab and Radiation Therapy, Surgery and Radiation Therapy
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- American Scitech International
Rectal or Anal Cancer
Dose Escalation Trial of Endoluminal High-Dose-Rate Brachytherapy With Concurrent Chemotherapy for Rectal or Anal Cancer in Patients With Recurrent Disease or Undergoing Non-Operative Management
The purpose of this study is to see what amount of radiation is safe to give to rectal or anal cancer patients who are being treated with a procedure called brachytherapy.
- Trial name
- NCT02199236
- Testing
- endorectal brachytherapy, concurrent capecitabine or 5-FU, Questionnaires
- Where
- 7 sites in United States
- Volunteers
- 15 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer Stage IV, Metastasis
Perioperative Chemotherapy Plus Cetuximab Versus Chemotherapy Alone for High Risk Resectable Colorectal Liver Metastasis
This study was designed to analyze the prognosis and recurrence predictive factors of high risk patients (Clinical Risk Score≥3) of resectable colorectal liver metastasis.
- Trial name
- PARECEC (NCT03031444)
- Testing
- Cetuximab plus FOLFIRI/FOLFOX, FOLFIRI/FOLFOX/CapeOX
- Where
- 4 sites in China
- Volunteers
- 135 people
- Sponsor
- Peking University Cancer Hospital & Institute
Metastatic Cancer, Solid Tumor
LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors
A Phase 1/2 Open-label, Multi-center Study of the Safety, Pharmacokinetics, and Anti-tumor Activity of LYT-200 Alone and in Combination with Chemotherapy or Tislelizumab in Patients with Metastatic Solid Tumors
- Conditions
- Metastatic Cancer, Solid Tumor, Pancreatic Cancer, Urothelial Carcinoma
- Trial name
- NCT04666688
- Testing
- LYT-200, Tislelizumab, Gemcitabine/nab-paclitaxel
- Where
- 12 sites in United States
- Volunteers
- 44 people
- Sponsor
- PureTech
Microsatellite Instability High, Mismatch Repair Deficiency
Anti-PD-1 +/- RT for MSI-H Solid Tumors
To determine if the out-of-field ORR is improved with the addition of radiation therapy to anti-PD-1 for patients with MSI-H/dMMR metastatic solid tumors.
- Conditions
- Microsatellite Instability High, Mismatch Repair Deficiency, Colorectal Cancer
- Trial name
- NCT04001101
- Testing
- RT and Anti-PD-1, Anti-PD-1
- Where
- United States
- Sponsor
- University of Colorado, Denver
Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
The purpose of this study is to characterize the safety and tolerability of KFA115 and KFA115 in combination with pembrolizumab in patients with select advanced cancers, and to identify the maximum tolerated dose and/or…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma, Carcinoma, Renal Cell, Carcinoma, Ovarian Epithelial
- Trial name
- NCT05544929
- Testing
- KFA115, pembrolizumab
- Where
- 18 sites in United States, Canada and 10 more
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
Anal Cancer
Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients With Locally Advanced Anal Cancer
RATIONALE: Drugs used in chemotherapy, such as mitomycin, fluorouracil, and cisplatin, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00068744
- Testing
- cisplatin, fluorouracil, mitomycin C
- Where
- 24 sites in Belgium, Egypt and 5 more
- Volunteers
- 88 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer, Liver Metastasis Colon Cancer
The CLiFF Study: Change in Liver Function and Fat in Pre-operative Chemotherapy for Colorectal Liver Metastases
The CLiFF Study will assess changes in liver function and liver fat in patients with colorectal liver metastases (CLM) undergoing pre-operative chemotherapy before liver resection.
- Conditions
- Colorectal Cancer, Liver Metastasis Colon Cancer, Chemotherapy Effect, Obesity
- Trial name
- CLiFF (NCT03562234)
- Testing
- MR, LiMAx
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University of Manchester
Hyperthermia, Colorectal Neoplasms
Impact of an Optimised Monitored Anesthesia on the Patients' Recovery After Cytoreduction Surgery Plus HIPEC
The objective of our PILOT study is to evaluate the impact of a controlled (monitored) randomized anesthesia during cytoreductive surgery with HIPEC to oxaliplatin in order to treat adenocarcinomas of colorectal origin.
- Conditions
- Hyperthermia, Colorectal Neoplasms, Oxaliplatin
- Trial name
- CHIPNOL (NCT04104334)
- Testing
- Remifentanil infusion, desflurane titration and fluid infusion will be guided by NOL index, BIS index and Flotrac EV1000 system respectively, Remifentanil infusion and desflurane titration will be guided by anesthesia usual practices
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Colorectal Cancer, Pancreas Cancer
Maintenance Dovitinib for Colorectal and Pancreas Cancer
This study is for patients with stage 4 colon cancer who have had initial chemotherapy or had surgery to remove metastases and patients with pancreas cancer, which has been surgically removed and are receiving adjuvant…
- Trial name
- NCT01888965
- Testing
- Dovitinib
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Georgetown University