Clinical trials: Patients on Mechanical Ventilation Support
Respiratory Insufficiency
Impact of the Assisted Ventilation Mode on Diaphragm Efficiency in Critically Ill Patients
This study evaluates the impact of the assisted mode of mechanical ventilation on diaphragm efficiency in mechanically ventilated critically ill patients.
- Trial name
- NAVA_PSV (NCT02473172)
- Testing
- Pressure Support ventilation, Neurally Adjusted Ventilatory Assist
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Bari
Critical Illness, Enteral Nutrition
Early Enteral Feeding and Clinical Outcomes in ICU Patients
This study evaluated the effectiveness of an early enteral feeding protocol in critically ill adult patients admitted to an Intensive Care Unit (ICU).
- Conditions
- Critical Illness, Enteral Nutrition, Intensive Care Unit ICU, Nutritional Support
- Trial name
- EEFP (NCT07131098)
- Testing
- Early Enteral Feeding Protocol, Standard Nutritional Care
- Where
- Palestinian Territories
- Volunteers
- 80 people
- Sponsor
- Loai Muawiah Zabin
Respiration Disorders
Multicenter Prospective Observational Study on Diaphragmatic Function Assessment by Ultrasound in Patients With Acute Respiratory Failure Receiving Non-invasive Mechanical Ventilation or High Flow Nasal Canula
The primary goal of this study is to assess diaphragm function in patients with acute respiratory failure before and during the use of high-flow oxygen and/or non-invasive breathing support.
- Trial name
- DIAFUSION (NCT06892912)
- Testing
- Diaphragmatic ultrasound
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Foro Internacional en Cuidado Crítico
Bronchial Secretion Retention
The Efficacy of Breathing Exercise With BreatheMAX Device on Airway Secretion Clearance and Lung Function
The efficacy of breathing exercise with oscillated inspiratory loading and oscillated positive expiratory pressure for airway secretion clearance and lung function in intubated patients, both with and without mechanical…
- Trial name
- BMACPF (NCT02553200)
- Testing
- BreatheMAX (OPEP), BreatheMAX (OIS and OPEP), BreatheMAX (unload and non-oscillated)
- Where
- Thailand
- Volunteers
- 28 people
- Sponsor
- Khon Kaen University
Oral Mucosal Disorder
Effects of Chlorhexidine Gluconate, Ozonated Water and Hypochlorous Acid Solutions Used in the Oral Care of Patients Supported by Mechanical Ventilation on the Integrity of the Oral Mucosa
The purpose of this clinical trial is to learn whether ozonated water and hypochlorous acid solution can restore the integrity of the oral mucosa.
- Trial name
- NCT06942026
- Testing
- Control 1
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Acute Respiratory Failure
Research on Respiratory Support Decision-Making for Mechanically Ventilated ICU Patients Based on a Physiological World Model
Mechanical ventilation is essential for ICU patients with respiratory failure, yet ventilator adjustment and weaning decisions remain experience-dependent and highly variable.
- Trial name
- NCT07834671
- Where
- China
- Volunteers
- 4,232 people
- Sponsor
- Ruijin Hospital
Thoracic Surgery
Patient-ventilator Asynchrony in Conventional Ventilation Modes During Short-term Mechanical Ventilation After Cardiac Surgery
This study evaluates the effects of VCV, PCV and PSV ventilatory modes during the immediate postoperative period on the variables resulting from regional and global pulmonary electrical impedance and diaphragmatic mobility, as…
- Trial name
- NCT03141216
- Testing
- VCV+PSV, PCV+PSV
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Universidade Federal de Pernambuco
Extra-Corporeal Life Support
Extubation of Patients on ECLS is Associated With a Reduction in Complications Related to Mechanical Ventilation: Retrospective Single-centre Study
There are no clear recommendations concerning the management of patients on ECLS (Extra-Corporeal Life Support). Many teams keep patients sedated until removal of the ECLS so as to avoid accidents, notably decannulation.
- Trial name
- EXTUB ECLS (NCT03295357)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Non Invasive Ventilation, Patient Ventilator Interaction
Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction
The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive…
- Trial name
- NCT01074866
- Testing
- Neurally Adjusted Ventilatory Assist
- Where
- 4 sites in Belgium, Switzerland
- Volunteers
- 13 people
- Sponsor
- University Hospital, Geneva
Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome
A Randomized Study to Investigate the Effect of Intravenous Imatinib on the Amount of Oxygen in the Lungs and Blood of Adults With COVID-19 Needing Mechanical Ventilation and Supportive Care.
The COVID-19 pandemic has led to an increase in the number of patients admitted to intensive care units (ICU) with acute respiratory distress syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome, Covid19, ARDS
- Trial name
- IMPRESS COVID (NCT04953052)
- Testing
- Imatinib Mesylate
- Where
- 8 sites in India
- Sponsor
- Exvastat Ltd.
Acute Respiratory Distress Syndrome
Driving Pressure as a Predictor of Mechanical Ventilation Weaning Time on Post-ARDS Patients in Pressure Support Ventilation.
With the birth of Mechanical Ventilation in the 1950s came the ventilation induced lung injuries (VILI). Numerous works have since then shown the benefit of "protective ventilation", notably by controlling the delivered tidal…
- Trial name
- PMVS (NCT04078984)
- Testing
- Experimental
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Bordeaux
Respiratory Muscle Weakness, Mechanical Ventilation Weaning
Progressive Pressure Support Reduction as Inspiratory Muscle Endurance Training in Mechanically Ventilated Patients
Mechanical ventilation causes rapid diaphragm muscle atrophy, detectable within 18 hours of ventilator support, which is a major contributor to weaning failure and prolonged ICU stay.
- Conditions
- Respiratory Muscle Weakness, Mechanical Ventilation Weaning, Physiotherapy, Endurance Training
- Trial name
- inspira-rct (NCT07689110)
- Testing
- Progressive Pressure Support Reduction (IRT-PS), Standard ICU Care
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Patient Comfort, Anxiety
Family Support Weaning from Mechanical Ventilation in Cardiovascular Surgery
Mechanical ventilation support is used to ensure airway clarity in patients after surgery.If patients are not informed about mechanical ventilation treatment in the pre -operation period, panic, anxiety and comfort may be…
- Conditions
- Patient Comfort, Anxiety, Patient Satisfaction
- Trial name
- NCT05820789
- Testing
- Family support
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kastamonu University
Intermittent Fasting, Septic Shock
Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit
This study aims to evaluate the efficiency of intermittent enteral nutrition versus continuous enteral nutrition to prevent from organ failures for patients at the acute phase of sepsis shock with mechanical ventilation in ICU.
- Conditions
- Intermittent Fasting, Septic Shock, Organ Failure, Multiple
- Trial name
- ENNUT-CI (NCT06330610)
- Testing
- Intermittent enteral nutrition
- Where
- France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Rouen
Critical Illness, Respiratory Failure (Pediatric Patients)
Ventilator Settings and Outcomes in Pediatric Patients on ECMO for Severe Respiratory Failure
This study aims to describe the effects of ECMO initiation on the intensity of ventilation in the first 24 hours after ECMO initiation and to explore associations between changes in ventilation intensity and hospital mortality in…
- Trial name
- NCT06899009
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- University Medical Center Groningen
Analgesia, ICU Patients Requiring Invasive Mechanical Ventilation
Clinical Study on the Efficacy and Safety of Hydromorphone for ICU Analgesia
This study is a prospective, single-center clinical study to evaluate the advantages, extensibility and safety of hydromorphone as an analgesic drug in ICU, and to compare it with remifentanil, a traditional sedative drug.
- Trial name
- NCT06848452
- Testing
- no-intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Affiliated Hospital of Nantong University
Respiratory Failure
Effect of Inspiratory Muscle Training on Duration of Mechanical Ventilation Support
A growing body of knowledge has documented that the diaphragm, the primary muscle of breathing, atrophies and weakens within days of instituting mechanical ventilation support.
- Trial name
- NCT01108575
- Testing
- IMST
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Florida
Critical Care, Acute Hypoxic Respiratory Failure
Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial
The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator-Induced Lung Injury
- Trial name
- IT-PSV (NCT06526598)
- Testing
- PMI-targeted pressure support setting and adjustment, VT/RR-targeted pressure support setting and adjustment
- Where
- China
- Volunteers
- 619 people
- Sponsor
- Capital Medical University
Noctural Ventilatory Mode and Weaning Duration
Impact of a Nocturnal Pressure Controlled Ventilation on Mechanical Ventilation Weaning Duration in Patients With Chronic Obstructive Respiratory Diseases
The weaning of mechanical ventilation is difficult period. This period is particularly difficult for patient with obstructive chronic respiratory disease and a long mechanical ventilation is associated with an increased risk of…
- Trial name
- REVENTIL 2 (NCT03428737)
- Testing
- Nocturnal controlled pressure control ventilation, Pressure support ventilation
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
The Effect of Two Different Bed Baths, Patients on Mechanical Ventilation Support
The Effect of Two Different Bed Baths Applied to Patients on Mechanical Ventilation Support
The aim of this study was to determine the effect of two different methods (traditional bed bathing and disposable antibacterial wipe bathing) on vital signs in patients on mechanical ventilation support.
- Trial name
- NCT05762081
- Testing
- Disposable Wipes for wiping baths, Traditional bed bath
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa