Clinical trials: Patients with Multiple Sclerosis
Relapsing Multiple Sclerosis
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
A study to evaluate the efficacy and safety of fenebrutinib on disability progression and relapse rate in adult participants with RMS.
- Trial name
- FENhance (NCT04586010)
- Testing
- Fenebrutinib, Teriflunomide
- Where
- 158 sites in United States, Argentina and 21 more
- Volunteers
- 746 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis
A Study to Evaluate the Safety of Administering Ocrelizumab Per a Shorter Infusion Protocol in Participants With Primary Progressive Multiple Sclerosis (PPMS) and Relapsing Multiple Sclerosis (RMS)
This study is an open-label, non-randomized study to evaluate rate and severity of infusion-related reactions (IRRs) of ocrelizumab infused over a shorter time period than the approved administration rate in participants with…
- Trial name
- NCT03606460
- Testing
- Ocrelizumab Dose 1, Ocrelizumab Dose 2 and Dose 3
- Where
- 5 sites in United States
- Volunteers
- 141 people
- Sponsor
- Genentech, Inc.
Multiple Sclerosis, Reliability and Validity
Validity and Reliability of Timed Up and Go Test in Dual-Task Conditions for Multiple Sclerosis Patients
his study aims to examine the validity and reliability of the Timed Up and Go (TUG) test in patients with Multiple Sclerosis (MS) under dual-task conditions, where participants perform both a motor and a cognitive task at the…
- Conditions
- Multiple Sclerosis, Reliability and Validity, Dual Task
- Trial name
- NCT07462338
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Sanko University
Multiple Sclerosis
Auditory Function in Patients With and Without Multiple Sclerosis
We propose to evaluate auditory function and neuropsychologic function in 150 Multiple Sclerosis (MS) patients and in 150 patients who do not have MS.
- Trial name
- NCT00037947
- Testing
- Hearing in Multiple Sclerosis
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- US Department of Veterans Affairs
Multiple Sclerosis
Electrical Brain Stimulation for Treatment of Secondary Symptoms in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease associated with physical disability, psychological impairment, and cognitive dysfunction. As a result, the disease burden is high, and treatment options are limited.
- Trial name
- NCT06401928
- Testing
- transcranial direct current stimulation, transcranial direct current stimulation combined with cognitive training
- Where
- Iran
- Volunteers
- 53 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Tuberous Sclerosis Complex (TSC), Lymphangioleiomyomatosis (LAM)
Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM)
This study will evaluate the safety and efficacy of RAD001 in treating patients with Angiomyolipoma associated with Tuberous Sclerosis Complex or Sporadic Lymphangioleiomyomatosis.
- Trial name
- EXIST-2 (NCT00790400)
- Testing
- Everolimus (RAD001)
- Where
- 25 sites in United States, Canada and 9 more
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Comparing the Acute Effects of Different Exercise Approaches in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is the second most common neurological disorder in young adults after trauma. Treatments developed today can slow progression and reduce symptoms.
- Trial name
- NCT06721416
- Testing
- Traditional Aerobic Exercise, VR Based Aerobic Exercise, Conventional Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Acibadem University
Multiple Sclerosis
Evaluation of an Altered Peptide Ligand (NBI-5788) in Patients With Relapsing Multiple Sclerosis (MS)
We are studying this investigational drug treatment, comparing it with placebo, to evaluate whether it is effective in reducing the number of MRI lesions with a minimum number of side effects.
- Trial name
- NCT00079495
- Testing
- NBI-5788
- Volunteers
- 150 people
- Sponsor
- Neurocrine Biosciences
C10.114.375.500
Influence of Socio-Economic Factor on Net Survival in Patients With Multiple Sclerosis in France ( ECOVIMUS).
Background: In comparison to general population, persons with Multiple Sclerosis have a higher risk to premature death with an estimate reduced life expectancy from 7 to 14 years.
- Trial name
- ECOVIMUS (NCT04028232)
- Where
- 18 sites in France
- Volunteers
- 30,000 people
- Sponsor
- University Hospital, Caen
Relapsing-Remitting Multiple Sclerosis
A fMRI(Functional Magnetic Resonance Imaging) Research Study to Learn More About Multiple Sclerosis and Individuals Potentially Experiencing Memory Difficulties
The purpose of this study is to determine if medication designed to improve memory will help patients with Multiple Sclerosis (MS) who are experiencing memory problems using fMRI to track brain activity.
- Trial name
- NCT00315367
- Testing
- Donepezil HCI (drug)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Neurognostics
Multiple Sclerosis
BAY86-5046 (Betaseron), Non Interventional Studies
This study aims to investigate adherence to therapy among patients treated with Betaferon who are using the BETACONNECT autoinjector.
- Trial name
- BETAEVAL (NCT02121444)
- Testing
- Interferon beta-1b (Betaferon, BAY 86-5046), BETACONNECT auto-injector.
- Where
- Germany
- Volunteers
- 151 people
- Sponsor
- Bayer
Multiple Sclerosis, Physical Therapy
Vojta Therapy in Multiple Sclerosis.
This Study evaluates the effectiveness of a Vojta locomotion reflex program as short-term automatic postural control in patients with Multiple sclerosis
- Trial name
- NCT03887507
- Testing
- Vojta Therapy, Standard Program
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- NUMEN Foundation
Multiple Sclerosis, Progressive Multifocal Leukoencephalopathy
Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia
This study will evaluate the risk of progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by John Cunningham virus (JCV), among people with multiple sclerosis who have been treated with ozanimod.
- Trial name
- NCT07732907
- Testing
- Ozanimod
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Bristol-Myers Squibb
Multiple Sclerosis
Adverse Childhood Experiences in Patients With MS: Impact on Quality of Life and on Coping Strategies Towards the Disease and Its Treatment
The goal of this observational study is to evaluate the presence of adverse childhood experiences (ACE) in patients with Multiple Sclerosis.
- Trial name
- ACE-MS (NCT06718920)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Multiple Sclerosis
Efficacy and Safety of FTY720 in Patients With Relapsing Multiple Sclerosis (MS)
To provide efficacy and safety data of two doses (0.5 mg and 1.25 mg) of FTY720 in Japanese patients with relapsing multiple sclerosis (MS)
- Trial name
- NCT00537082
- Testing
- FTY720
- Where
- 18 sites in Japan
- Volunteers
- 171 people
- Sponsor
- Novartis
Multiple Sclerosis
Inspiratory Muscle Training in Multiple Sclerosis
Objective: To evaluate the effectiveness of a low-intensity protocol of inspiratory muscle training (IMT) to improve respiratory strength, spirometric parameters and dyspnea in patients with multiple sclerosis (MS).
- Trial name
- NCT03887546
- Testing
- Inspiratory muscle trainer, Respiratory exercise
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Multiple Sclerosis, Multiple Sclerosis Fatigue
Solriamfetol for the Treatment of Multiple Sclerosis Fatigue
Fatigue is a prevalent and disabling symptom in Multiple Sclerosis (MS), affecting up to 90% of patients. Current treatments, including off-label prescriptions of wake-promoting agents, have shown limited effectiveness.
- Trial name
- SOLARIMS (NCT06170970)
- Testing
- Solriamfetol
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis
Aerobic Training Effects on Motor and Cognitive Performances in MS: an Exploratory Study With Structural and Functional MRI
Aerobic training (AT) induces cardiovascular, metabolic and muscular changes and has been proposed as a promising rehabilitative approach in elderly adults and in neurological patients to improve both motor and cognitive…
- Trial name
- NCT04097418
- Testing
- Aerobic training compared to conventional motor training
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Double Blind Combination of Rituximab by Intravenous and Intrathecal Injection Versus Placebo in Patients With Low-Inflammatory Secondary Progressive Multiple Sclerosis (RIVITaLISe)
Background: Secondary-progressive multiple sclerosis (SP-MS) is the chronic phase of multiple sclerosis (MS). The majority of people who have relapsing-remitting MS eventually develop SP-MS.
- Trial name
- NCT01212094
- Testing
- Rituximab, normal saline
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis
The Validity and Reliability of the Upper Extremity Exercise Testing (UULEX) in Patients With Multiple Sclerosis
Multiple sclerosis negatively affects the endurance and functionality in the upper extremities. 20 female patients aged 18-70 years who were diagnosed with MS will be included in the study.
- Trial name
- NCT04979819
- Testing
- Upper extremity endurance test (UULEX)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
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