Clinical trials: Pediatric ARDS
Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases
IPV and Lung Compliance in Invasively Ventilated Children
The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation.
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases, Lung Compliance
- Trial name
- NCT06836050
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University
Pediatric Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
Prone Position During ECMO in Pediatric Patients With Severe ARDS
In 2023, the second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) updated the diagnostic and management guidelines for Pediatric Acute Respiratory Distress Syndrome (PARDS).
- Trial name
- PEPAD (NCT06369584)
- Testing
- prone position
- Where
- 8 sites in China
- Volunteers
- 7 people
- Sponsor
- Seventh Medical Center of PLA General Hospital
Respiratory Failure
Closed-loop FiO2 Controller During High Flow Oxygen Treatment In Pediatric Patients (COFICOHFOT)
Recently, high flow oxygen therapy (HFOT) is becoming more popular in the treatment of any kind of respiratory failure. Pediatric mechanical ventilation consensus conference (PEMVECC) guidelines suggest measuring oxygen…
- Trial name
- COFICOHFOT (NCT05032365)
- Testing
- Close-loop FiO2 controller, Conventional
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Acute Respiratory Distress Syndrome (ARDS), Cardiogenic Shock
Cerebral Autoregulation in Pediatric ECMO (ECMOX 2)
Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Cardiogenic Shock, Cardiac Arrest
- Trial name
- ECMO-ECMOX2 (NCT04548739)
- Where
- 4 sites in France, Italy
- Volunteers
- 132 people
- Sponsor
- Nantes University Hospital
Acute Respiratory Distress Syndrome (ARDS), Ventilator Management
Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial
Acute respiratory distress syndrome (ARDS) is a serious and potentially life-threatening lung condition that can affect children.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Ventilator Management, Lung-protective Ventilation, Pediatric Acute Respiratory Distress Syndrome (PARDS)
- Trial name
- PARMA (NCT07123961)
- Testing
- High Driving Pressure Mechanical Ventilation, Low Driving Pressure Mechanical Ventilation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Children's Hospital of Philadelphia
Lung Collapse, Lung Diseases
The Accuracy of Pediatric Air Test as a Non-invasive Atelectasis Diagnostic Tool
HYPOTHESIS: During anesthetic pre-oxygenation with high FiO2, pulmonary atelectasis occur, especially in patients < 6 years old, where FRC and pulmonary closing volume may overlap.
- Conditions
- Lung Collapse, Lung Diseases, Atelectasis, Atelectasis Without Respiratory Distress Syndrome
- Trial name
- NCT04506203
- Testing
- Air test
- Where
- 3 sites in Argentina, Spain
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
COVID-19, SARS-CoV-2 Infection
Clinical Characteristics and Outcomes of Pediatric COVID-19
Rationale: The clinical manifestations of SARS-CoV-2 infection in children are poorly characterized. Preliminary findings indicate that they may be atypical.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Pediatric ALL, Pneumonia, Viral
- Trial name
- PERN-COVID-19 (NCT04330261)
- Testing
- Exposure (not intervention) - SARS-CoV-2 infection
- Where
- Canada
- Volunteers
- 10,610 people
- Sponsor
- University of Calgary
Respiratory Insufficiency, Respiratory Distress Syndrome, Newborn
Sedation Management in Pediatric Patients With Acute Respiratory Failure (The RESTORE Study)
People with acute respiratory failure usually require the use of an artificial breathing machine, known as a mechanical ventilator.
- Conditions
- Respiratory Insufficiency, Respiratory Distress Syndrome, Newborn, Lung Diseases
- Trial name
- RESTORE (NCT00814099)
- Testing
- Team approach to sedation management, Usual approach to sedation management
- Where
- 31 sites in United States
- Volunteers
- 2,449 people
- Sponsor
- University of Pennsylvania
Positive End-expiratory Pressure (PEEP), Oxygenation Index
Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation
The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric…
- Conditions
- Positive End-expiratory Pressure (PEEP), Oxygenation Index, Pediatric Intensive Care Unit, Pediatric Acute Lung Injury
- Trial name
- NCT07233304
- Testing
- Alveolar Opening Maneuver and PEEP Titration (AOM+P)
- Where
- Argentina
- Volunteers
- 143 people
- Sponsor
- Hospital de Alta Complejidad en Red
Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia
Altitude and Outcomes in Pediatric ARDS: A Multicenter Study
This multicenter observational study will evaluate the association between geographic altitude, availability of critical care resources, and clinical outcomes in children with pediatric acute respiratory distress syndrome…
- Conditions
- Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia, High Altitude Effects
- Trial name
- LARed-ALT (NCT07193771)
- Testing
- Geographic Altitude
- Where
- 20 sites in Bolivia, Chile and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Latin American Pediatric Collaborative Network
ARDS
Predictive Value of Troponin I for Acute Respiratory Distress Syndrome in Children With Shock
Shock is one of the five leading causes of income and mortality in emergencies. It generates a decrease in the availability of oxygen to the tissues, resulting in ischemia, pulmonary involvement and tissue reperfusion syndrome.
- Trial name
- NCT02361840
- Where
- Mexico
- Volunteers
- 65 people
- Sponsor
- Hospital Civil de Guadalajara
Pediatric Acute Respiratory Distress Syndrome
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced.
- Trial name
- NCT06684119
- Testing
- Electrical Impedance Tomography positive end-expiratory pressure titration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Los Angeles
Pediatric Respiratory Diseases, Bronchiolitis
Assessment of NeuroBOX and NeuroPAP in Infants.
Non-invasive ventilation (NIV, delivered via a mask or cannulas) permits to reduce the need for tracheal intubation in infants who needs a ventilatory support.
- Conditions
- Pediatric Respiratory Diseases, Bronchiolitis, Infant Respiratory Distress Syndrome
- Trial name
- NeuroPap2 (NCT03650478)
- Testing
- NeuroPAP ventilation (2h) and NeuroBox monitoring (23h), NeuroPAP ventilation (4h) and NeuroBox monitoring (25h)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Pediatric Acute Respiratory Distress Syndrome
Post-discharge Outcomes of Pediatric Acute Respiratory Distress Syndrome
In this study, the investigators aim to better characterize the outcomes of pediatric acute respiratory distress syndrome (PARDS) survivors, to examine whether subgroups of children with PARDS can be identified, and to determine…
- Trial name
- PARDS (NCT03585582)
- Testing
- Prospective follow-up
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- St. Justine's Hospital
Acute Respiratory Distress Syndrome
Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction [AVDSf]) is more strongly associated with mortality risk than markers of oxygenation abnormality…
- Trial name
- DiNO (NCT06690801)
- Where
- 10 sites in United States
- Volunteers
- 1,260 people
- Sponsor
- Children's Hospital Los Angeles
Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure
Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement
Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and…
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- DECFVTTPM (NCT06051292)
- Testing
- Fast method, Conventional method
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Asthma, Pneumonia
PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress
This study will investigate the efficacy of a novel air purification technology, Photo Electrochemical Oxidation (PECO), has on pediatric patients hospitalized for respiratory distress.
- Conditions
- Asthma, Pneumonia, Respiratory Distress Syndrome
- Trial name
- NCT03647397
- Testing
- Photo Electrochemical Oxidation (PECO) for Air Purification
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Molekule
Pediatric ARDS
The Specific Elastance in ARDS Patients: a Pediatric Study
Aim of this study is to assess lung specific elastance in a population of pediatric patients with Acute Respiratory Distress Syndrome (ARDS) treated with mechanical ventilation, and in a pediatric population of ICU patients with…
- Trial name
- NCT02036801
- Testing
- Lung specific elastance
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital
Respiratory Failure, Respiratory Distress Syndrome
Ventilator Induced Diaphragm Dysfunction in Pediatric Critically Ill Patients (VIDD)
evaluation of diaphragmatic disfunction eventually occurred in pediatric patient undergoing mechanical ventilation therapy
- Conditions
- Respiratory Failure, Respiratory Distress Syndrome, Mechanical Ventilation Complication
- Trial name
- VIDD (NCT03768232)
- Testing
- ultrasound asessment
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute