Clinical trials: Pediatric Cancers
Pediatric Cancer
Adapted Physical Activity for Children Treated With Cancer and Insulin Sensitivity
The main objective of this study is to evaluate the evolution of the sensitivity to insulin, a hormone that acts on sugar in the body, as well as other metabolic, motor and nutritional elements of children with cancer, according…
- Trial name
- APACIS (NCT05383092)
- Testing
- Adapted Physical Activity Strong
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Leukemia, Lymphoma
Phase I Study of Intrathecal Mafosfamide
The purpose of this study is to determine efficacy of intrathecal mafosfamide, a preactivated derivative of cyclophosphamide against meningeal malignancies refractory to conventional therapy (radiation therapy and chemotherapy).
- Conditions
- Leukemia, Lymphoma, Meningeal Neoplasm
- Trial name
- NCT00001251
- Testing
- Mafosfamide
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Pediatric Cancer
An eHealth Psychosocial Intervention for Caregivers of Children With Cancer
The psychosocial needs of children with cancer and their families are well-documented in the literature, including the increased risk of parental posttraumatic stress, parental anxiety, and decreased family functioning.
- Trial name
- NCT05333601
- Testing
- eSCCIP
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Choledochal Cyst Resection
Factors Affecting Postoperative Recovery From Common Bile Duct Cysts in Children: A Multicenter Retrospective Analysis Based on Perioperative Clinical Characteristics
This retrospective study aims to systematically analyze the factors influencing short-term rehabilitation and liver function recovery after radical surgery for pediatric common bile duct cysts, identify independent risk factors…
- Trial name
- NCT07800169
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Wuhan Children's Hospital
Leukemia
Genetic Test in Detecting Minimal Residual Disease in Samples From Younger Patients Registered on the COG-AALL08B1 Trial
RATIONALE: Testing for minimal residual disease in blood samples from patients with acute lymphoblastic leukemia may help doctors plan better treatment.
- Trial name
- NCT01629745
- Testing
- gene expression analysis, flow cytometry, laboratory biomarker analysis
- Volunteers
- 99 people
- Sponsor
- Children's Oncology Group
Liver Tumor
Pediatric Hepatic Tumors
Centralized biological collection of multicentric origin, retrospective and prospective of biological samples (tissues and fluids) taken within the framework of the diagnostic and therapeutic management of children and…
- Trial name
- HEPATOBIO (NCT04274868)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Osteonecrosis, Acute Lymphoblastic Leukemia
Osteonecrosis in Children With Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia is the most common form of childhood cancer with current treatment survival rates approaching 80%. Improved outcomes show an increased number of survivors at risk for long-term treatment related side…
- Trial name
- NCT01104324
- Where
- 10 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Halton, Jacqueline, M.D.
Histiocytosis, Pediatric Patients With Cancer
Ceftriaxone in Non-neutropenic Fever
This is a retrospective chart review of all patients cared for at Monroe Carell Jr. Children's Hospital at Vanderbilt including the following: patients between 2007-2009 with malignancy, Langerhans cell histiocytosis (LCH) or…
- Trial name
- NCT01225718
- Where
- United States
- Volunteers
- 463 people
- Sponsor
- Vanderbilt University Medical Center
Pediatric Cancer
Effects of Yoga on Children With Cancer
This study was planned as a randomized controlled experimental study with a pre-test-post-test design to determine the effect of yoga practice accompanied by a specialist yoga instructor on fatigue, quality of life and symptom…
- Trial name
- NCT06651918
- Testing
- yoga practise
- Volunteers
- 20 people
- Sponsor
- TC Erciyes University
Trauma and Stressor Related Disorders, Pediatric Cancer
Emotion and Symptom-Focused Engagement (EASE) for Caregivers
The goal of this Phase III randomized controlled trial is to evaluate the effectiveness of a novel psychotherapeutic intervention called Emotion and Symptom-focused Engagement (EASE) in parents caring for a child or adolescent…
- Conditions
- Trauma and Stressor Related Disorders, Pediatric Cancer, Caregiver Burden
- Trial name
- EASE (NCT06367556)
- Testing
- Emotion and Symptom-Focused Engagement (EASE)
- Where
- 2 sites in Canada
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Pediatric Cancer
Decision-making Preferences and Its Related Factors on Parents With Children Having Cancer
A cross-sectional correlational study was conducted in the pediatric hematology-oncology ward and outpatient clinic of a medical center in southern Taiwan.
- Trial name
- NCT06618066
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Solid Tumors
Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Participants With Previously Treated Solid Tumors
This open-label, dose-escalation study is designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of cobimetinib in pediatric and young adult participants with solid tumors with known or…
- Trial name
- iMATRIXcobi (NCT02639546)
- Testing
- Cobimetinib
- Where
- 17 sites in United States, France and 5 more
- Volunteers
- 56 people
- Sponsor
- Hoffmann-La Roche
Pediatric Cancer, Adolescent Health
Decision Support Intervention of Minor Cancer Patients and Their Parents
The purpose of this stuidy are: (1) to explore the information needs of parents having children with cancer when making treatment decisions; (2) to develop a Taiwan version of the Control Preferences Scale for decision support…
- Conditions
- Pediatric Cancer, Adolescent Health, Decision Aids, Parents of Children With Cancer
- Trial name
- NCT06651242
- Testing
- Decision-making information aids, Routine care
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Leukemia
Temozolomide in Treating Young Patients With Refractory or Recurrent Leukemia
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00083070
- Testing
- temozolomide
- Where
- 16 sites in United States, Canada
- Volunteers
- 16 people
- Sponsor
- Children's Oncology Group
Pediatric ALL, Adolescent
Pediatric Normative Markerless Movement Analysis
The objective of this project is to collect baseline data from a normative population of 20 children that gender and age matches the population of patients expected to be treated by Mary Bridge Children's Research \& Movement Lab.
- Trial name
- NCT06249880
- Testing
- Observation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MultiCare Health System Research Institute
Osteosarcoma, Pediatric
Oncological and Functional Outcomes in Lower Limb Osteosarcoma Pediatric Patient
Retrospective analysis of specific characteristics of complications and long-term oncological and function outcomes in lower-limb osteosarcoma pediatric patients.
- Conditions
- Osteosarcoma, Pediatric, Lower Limb Injury, Outcome
- Trial name
- NCT06162962
- Testing
- Retrospective analysis
- Where
- China
- Volunteers
- 345 people
- Sponsor
- Changye Zou
Solid Tumor Cancer
Irinotecan Liposomes Combined with Temozolomide and Vincristine in the Treatment of Pediatric Patients with Solid Tumors
A prospective, single-center Ia/Ib clinical study divided into two parts, including Phase Ia Dose Exploration and Phase Phase Ib Extension Phase.
- Trial name
- NCT06710821
- Testing
- Liposomal irinotecan in combination with vincristine and temozolomide
- Volunteers
- 40 people
- Sponsor
- Yizhuo Zhang
Childhood Cancer
SurvivorLink: Scalability of an Electronic Personal Health Record
Previous research suggests that children and adolescents with cancer are at heightened risk of late effects that can occur months or years after cancer treatment, yet little is known about programs that increase their return for…
- Trial name
- NCT03543852
- Testing
- SurvivorLink
- Where
- 12 sites in United States
- Volunteers
- 542 people
- Sponsor
- Emory University
Pediatric Cancer, Grief
Feasibility Study of the Storytelling Through Music Intervention with Bereaved Parents
The death of a child, at any age, is considered one of the most stressful life events a person can experience. In 2020, 11,050 children (under 15 years), 5,000 adolescents (15-19 years) and 60,000 young adults (20-39 years) were…
- Conditions
- Pediatric Cancer, Grief, Well-Being, Psychological, Coping Strategies
- Trial name
- NCT06047808
- Testing
- Storytelling Through Music
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Texas at Austin
B-Cell Pediatric ALL
Study in Pediatrics With Relapsed or Refractory Pediatric Acute Lymphoblastic Leukemia (pALL) or Lymphoblastic Lymphoma
The primary objective of this study is to evaluate the efficacy of moxetumomab pasudotox in pediatric participants with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL) or B-cell lymphoblastic lymphoma.
- Trial name
- NCT02227108
- Testing
- Moxetumomab Pasudotox
- Where
- 21 sites in United States, Australia and 6 more
- Volunteers
- 37 people
- Sponsor
- MedImmune LLC
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