Clinical trials: Pellucid Marginal Corneal Degeneration
Keratoconus, Ectasia of Cornea
Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Keratoconus, Ectasia of Cornea, Pellucid Marginal Corneal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07124910
- Testing
- Epi-ON corneal cross-linking
- Where
- 12 sites in United States
- Volunteers
- 485 people
- Sponsor
- Woolfson Eye Institute
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04177082
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cornea Associates of Texas
Corneal Ectasia, Keratoconus
Safety and Effectiveness of the PXL-Platinum 330 System
To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.
- Conditions
- Corneal Ectasia, Keratoconus, Pellucid Marginal Corneal Degeneration
- Trial name
- NCT04401865
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Colorado Eye Consultants/Cornea Consultants of Colorado
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia
To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04094090
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Goodman Eye Center
Keratoconus, Pellucid Marginal Degeneration
T-Cat Laser & Cross-linking for Keratoconus
The purpose of this study is to determine whether excimer laser corneal surface ablation (T-Cat) can be safely combined with simultaneous corneal collagen cross-linking treatment to produce an improved and stable corneal profile…
- Trial name
- T-Cat (NCT00777322)
- Testing
- Excimer laser ablation, and collagen cross-linking
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01097447
- Where
- 5 sites in United States
- Volunteers
- 2,619 people
- Sponsor
- Cxlusa
Down Syndrome (DS), Keratoconus
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07135167
- Testing
- Epi-ON corneal cross-linking (CXL)
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- Woolfson Eye Institute
Keratoconus, Irregular Astigmatism
Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism
Aberrations are the spreading of light from a point focus. Aberrations of the eyes can be objectively evaluated with a wavefront aberrometer.
- Conditions
- Keratoconus, Irregular Astigmatism, Corneal Ectasia, Aberration, Corneal Wavefront
- Trial name
- WFG Sclerals (NCT04698590)
- Testing
- Wavefront Guided Scleral Lenses, Traditional Scleral Lenses
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus
CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Trial name
- NCT01956474
- Testing
- Theralight crosslinking and Riboflavin
- Where
- 6 sites in United States
- Volunteers
- 1,324 people
- Sponsor
- Cxlusa
Irregular; Contour of Cornea, Keratoconus
Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders
The most common causes for irregular cornea (IC) in hospital contact lens practice are Keratoconus (KC) and related cornea thinning disorders.
- Conditions
- Irregular; Contour of Cornea, Keratoconus, Pellucid Marginal Corneal Degeneration, Injury of Cornea
- Trial name
- NCT02444923
- Testing
- Scleral rigid gas permeable contact lenses (SRGPcl) (Zenlens™), Corneal Rigid gas Permeable contact lenses (CRGPcl) (Rose K2)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- London South Bank University
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04667572
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Cornea Associates of Texas
Keratoconus, Ocular Surface Disease
Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting
EYEdeal Scanning Technology enables rapid measurement of corneal and scleral topography. By accurately measuring the ocular surface with this imaging technology, the current iterative fitting method required to fit PROSE…
- Conditions
- Keratoconus, Ocular Surface Disease, Pellucid Marginal Corneal Degeneration, Ectasia
- Trial name
- NCT04649177
- Testing
- Ocular surface optical coherence tomography
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston Sight
Keratoconus, Pellucid Marginal Degeneration
Corneal Cross Linking and Topography Guided Excimer Laser Treatment
Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism.
- Trial name
- NCT01682993
- Testing
- Topography guided Excimer Laser treatment and Corneal Cross Linking, Corneal Cross Linking
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Keratoconus, Ectasia
Progressive Keratoconus or Ectasia Treatment Plan
Keratoconus and pellucid marginal degenerations are genetically based ocular conditions and post surgical ectasia is an iatrogenic condition.
- Trial name
- NCT01384773
- Testing
- Riboflavin Solution, UV-X Illumination System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stephen Trokel
Pellucid Marginal Corneal Degeneration, Keratoconus
A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea
The purpose of this research study is to find out if the new Brillouin Ocular Scanner can measure the variation (difference) of the corneal elastic changes involved in the onset of corneal ectasia, induced by LASIK surgery and…
- Conditions
- Pellucid Marginal Corneal Degeneration, Keratoconus, Keratectasia
- Trial name
- NCT03220529
- Testing
- Brillouin Ocular Scanner
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Corneal Diseases
Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions
The purpose of this study is to determine the ability of a proprietary software screening tool to discriminate normal corneas (front surface of the eye) from previously diagnosed corneal conditions…
- Trial name
- NCT00396188
- Where
- 4 sites in United States
- Volunteers
- 769 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01024322
- Testing
- Ciprofloxicine or Vigamox or other., Nonsteroidal (Acular, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Where
- 3 sites in United States
- Volunteers
- 1,189 people
- Sponsor
- Cxlusa
Keratoconus, Corneal Diseases
Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas
This study will assess changes in visual acuity and corneal symmetry after corneal collagen cross-linking (CXL) of asymmetric corneas.
- Conditions
- Keratoconus, Corneal Diseases, Eye Diseases, Photosensitizing Agents
- Trial name
- NCT03029104
- Testing
- CXLO Corneal Strengthening Solution and UVA Illumination Device
- Where
- 9 sites in United States
- Volunteers
- 2,228 people
- Sponsor
- Cxlusa