Clinical trials: Pelvic Prolapse
Pelvic Organ Prolapse
Expedited Versus Restrictive: Limitations on Activity Following Surgical Treatment of Prolapse
The objective of the EVeRLAST study is to determine whether expedited resumption of postoperative activity levels is non-inferior to standard activity restrictions with respect to short-term anatomic prolapse outcomes.
- Trial name
- EVeRLAST (NCT04329715)
- Testing
- Expedited postoperative activity instructions, Standard postoperative activity restructions
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Duke University
Pelvic Organ Prolapse, Menopause
Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor
This is a study to determine how vaginal estrogen cream given for several weeks before pelvic reconstructive therapy will effect elastic fiber assembly in the muscularis layer of the vaginal wall.
- Trial name
- PET (NCT01778985)
- Testing
- Premarin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pelvic Organ Prolapse
Vaginal Transluminal Endoscopic Sacrocolpopexy
This study aims to evaluate the outcomes of V-NOTES sacrocolpopexy following vaginal hysterectomy, focusing on perioperative and early postoperative results.
- Trial name
- NCT06004089
- Testing
- V NOTES Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Prolapse, Vaginal, Vaginal Vault Prolapse
Post-Hysterectomy Vaginal Length: Horizontal vs. Vertical Closure
This prospective clinical study aims to evaluate the impact of vaginal cuff closure orientation-horizontal versus vertical-on postoperative total vaginal length in patients undergoing vaginal hysterectomy combined with lateral…
- Trial name
- vagina (NCT07067645)
- Testing
- Horizontal Vaginal Cuff Closure Technique, Vertical Vaginal Cuff Closure Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Vaginal Prolapse, Cystocele
Comparative Study of Mesh Versus No Mesh in Prolapse Surgery
Hypothesis / aims of study A RCT has shown that results of prolapse repair via vaginal approach could be improved when a polypropylene mesh is used as tissue support (1).
- Trial name
- NCT00153257
- Testing
- Ugytex
- Where
- France
- Volunteers
- 162 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Genital Diseases, Female, Pelvic Organ Prolapse
A Long Term Follow up of Anterior Meshes for Recurrent Prolapse
Prolapse of the vaginal wall and uterus are common conditions affecting up to 50% of parous women. The socioeconomic, psychological and physical impacts of prolapse are considerable.
- Trial name
- NCT02642835
- Testing
- vaginal wall mesh
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Medway NHS Foundation Trust
Pelvic Organ Prolapse, Prolapse of Vaginal Vault After Hysterectomy
VITOM Study: A Randomized, Controlled Trial.
This is research in which students are queried by questionnaires on their satisfaction with and experience with certain educational practices (use of a camera image projecting during a live surgery) or with pre-recorded video.
- Conditions
- Pelvic Organ Prolapse, Prolapse of Vaginal Vault After Hysterectomy, Bulging of Vaginal Wall, Incontinence
- Trial name
- VITOM (NCT03120689)
- Testing
- Live Surgery using VITOM, Live Surgery without VITOM, Video viewing with VITOM
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI)
Development and Validation of a Risk Prediction Model for De Novo Stress Urinary Incontinence After Pelvic Floor Reconstruction Surgery
This observational study aims to develop a predictive model for the occurrence of new-onset stress urinary incontinence (SUI) after pelvic organ prolapse (POP) repair surgery in women.
- Trial name
- NCT07601282
- Testing
- Telephone follow-up
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pelvic Organ Prolapse
Sacrocolpopexy Versus Sacro-spinous Fixation for Prolapse Treatment
Prolapse is a condition that causes up to 13% of women to have surgery in their lifetime. There are many surgical techniques for the treatment of prolapse, each with its advantages and disadvantages.
- Trial name
- ProSac (NCT04878146)
- Testing
- Sacro-spinous fixation, Subtotal hysterectomy, Sacrocolpopexy
- Volunteers
- 132 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Pelvic Organ Prolapse
Vaginal Adventitia Reserved and Anatomical Implant Technique of Transvaginal Mesh Procedure for Pelvic Organ Prolapse
After obtaining an institutional ethics approval (#2021833), the investigators retrospectively reviewed patients with Pelvic organ prolapse (POP) who underwent Transvaginal Mesh (TVM) in their hospital during June 2008 and…
- Trial name
- NCT05707533
- Testing
- TVM using the Vaginal Adventitia Reserved and Anatomical Implant Technique
- Where
- China
- Volunteers
- 589 people
- Sponsor
- West China Hospital
Pelvic Organ Prolapse
Safety and Efficacy Study of the NeuGuide Device
This study aims to investigate the safety, efficacy, peri and postoperative complications, and patient satisfaction of sacro-spinous ligament fixation (SSLF) for the management of pelvic organ prolapse (POP).
- Trial name
- NCT02190825
- Testing
- NeuGuide device
- Where
- 2 sites in Israel
- Volunteers
- 15 people
- Sponsor
- Pop Medical Solutions
Pelvic Organ Prolapse, Cystocele
Study Comparing Transobturator Cystocele vs. Anterior Vaginal RepairS
Surgical correction of the prolapse in the anterior compartment remains one of the major challenges in urogynecology. Paravaginal defect in level II of vaginal fixation results in the majority of cystoceles.
- Conditions
- Pelvic Organ Prolapse, Cystocele, Cystocele and Incomplete Uterovaginal Prolapse
- Trial name
- STARS (NCT05602246)
- Testing
- Transobturator cystocele repair, Anterior colporrhaphy
- Where
- 8 sites in Czechia, Slovakia
- Volunteers
- 592 people
- Sponsor
- Charles University, Czech Republic
Stress Urinary Incontinence, Genital Prolapse
Dynamic MRI of the Behaviour of Female Pelvic Floor
The purpose of this study was to test the suitability of dynamic magnetic resonance imaging for the pelvic floor floor, bladder neck and urethra in healthy volunteers, in stress incontinent patient and in women with genital…
- Trial name
- NCT00747370
- Testing
- movement of midurethra, bladder neck, cervix and rectum
- Where
- Finland
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Urinary Bladder, Overactive, Urinary Bladder Neck Obstruction
Association With Low Compliance Bladder in Women With LUTS
Hypothesis / aims of study The clinical and urodynamic features on the severity of low compliance bladder in neurologically intact women with lower urinary tract symptoms are indeterminate.
- Conditions
- Urinary Bladder, Overactive, Urinary Bladder Neck Obstruction, Pelvic Organ Prolapse, Urinary Incontinence
- Trial name
- NCT06210477
- Testing
- medical treatment for lower urinary tract symptoms
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Urinary Dysfunction, Vaginal Prolapse
Effects of Kegel Ball and Pelvic Floor Exercises on Sexual Function, Unrınary Incontinence and Quality of Life in Women
Urinary incontinence and sexual dysfunction are common conditions that can significantly impact quality of life. Although surgical and medical treatments are available, many individuals seek non-invasive alternatives.
- Conditions
- Urinary Dysfunction, Vaginal Prolapse, Sexual Function Scores, Kegel Exercises
- Trial name
- NCT07048145
- Testing
- Vaginal Kegel Exercise Ball, Pelvic Floor Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- sahra sultan kara
Vaginal Infection, Urinary Tract Infection
Vaginal Estrogen With Pessary Treatment
Patients presenting with pelvic organ prolapse will be offered the use of a pessary. Vaginal estrogen cream treatment with the pessary will be randomized amongst the patients and patient satisfaction and complication rates will…
- Conditions
- Vaginal Infection, Urinary Tract Infection, Quality of Life
- Trial name
- NCT01843166
- Testing
- Premarin vaginal cream
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pelvic Organ Prolapse
Analysis of Procedural Times Using Colpassist for Robotic-Assisted Sacrocolpopexy; a Randomized Controlled Trial
The purpose of this study is to evaluate the efficiency of the Colpassist vaginal positioning device during robotic-assisted sacrocolpopexy.
- Trial name
- ACRAS (NCT02367235)
- Testing
- Traditional vaginal positioning device, Colpassist vaginal positioning device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of North Carolina, Chapel Hill
Pelvic Organ Prolapse, Surgical Mesh
Clinical Outcomes of Transvaginal Mesh Procedures for Cystocele Repair: Comparisons of Uphold and Perigee Systems
Pelvic organ prolapse (POP) is a major health concern, affecting more than 30% of women. The aim of this study was to compare the clinical outcomes of Uphold system and Perigee system in treating women with cystocele.
- Trial name
- NCT03764891
- Testing
- Uphold, Perigee
- Where
- Taiwan
- Volunteers
- 152 people
- Sponsor
- Far Eastern Memorial Hospital
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Urinary Tract Infection, Pelvic Organ Prolapse
L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract to Prevent Postoperative Urinary Tract Infection.
This study will include women who will undergo pelvic reconstructive surgery and/or anti-incontinence sling procedures. Patients will be randomized to the combination of L-methionine, Hibiscus Sabdariffa and Boswellia Leaf…
- Conditions
- Urinary Tract Infection, Pelvic Organ Prolapse, Urinary Incontinence
- Trial name
- NCT02216253
- Testing
- L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele