Clinical trials: Pemphigus, open to volunteers
Pemphigus Vulgaris, Pemphigus Foliaceus
Autoimmune Blistering Diseases Study
Pemphigus and bullous pemphigoid (BP) are severe autoimmune blistering diseases (AIBD) that pose a critical need for new therapeutic approaches.
- Conditions
- Pemphigus Vulgaris, Pemphigus Foliaceus, Bullous Pemphigoid
- Trial name
- AIBD (NCT02753777)
- Testing
- Questionnaires
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Pemphigus
A Single-center Study of CM313 in Patients With Pemphigus
A prospective, single-center, single-arm clinical study aimed to explore the efficacy and safety of the anti-CD38 monoclonal antibody CM313 combined with low-dose glucocorticoids in patients with pemphigus.
- Trial name
- NCT06904040
- Testing
- CM313 injection, glucocorticoids
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sichuan Provincial People's Hospital
Disasters, Disaster Preparedness
Effectiveness of an Audiovisual Disaster-Education Intervention on Disaster Risk Perception and Preparedness Belief Among Senior High-School Adolescents
This cluster-randomized controlled trial tests whether a short, standardized disaster-education video improves two psychological precursors of disaster preparedness among senior high-school students in a hazard-prone district of…
- Conditions
- Disasters, Disaster Preparedness, Health Behavior, Risk Perception
- Trial name
- DERAP (NCT07781527)
- Testing
- Audiovisual disaster-education module, Attention-matched general-health video
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Tanjungpura University
Pemphigus Vulgaris, Rituximab (RTx)
Rituximab With Corticosteroids Versus Corticosteroids Plus Azathioprine for Moderate-to-Severe Pemphigus Vulgaris
This quasi-experimental study aims to compare the effectiveness and safety of rituximab combined with corticosteroids versus the standard regimen of oral corticosteroids plus azathioprine in patients with moderate to severe…
- Trial name
- NCT07769333
- Testing
- Rituxan (rituximab), Azathioprine (AZA)' plus corticosteroids
- Volunteers
- 92 people
- Sponsor
- Khyber Teaching Hospital
Pemphigus Disease
Impact of a Lifestyle Program on Quality of Life in Pemphigus Patients
The aim of this study is To evaluate the impact of lifestyle modifications, including dietary changes and regular exercise, on skin-related quality of life in patients with pemphigus by assessing changes in Skindex-16 scores over…
- Trial name
- NCT06901427
- Testing
- Mediterranean Diet and exercise
- Volunteers
- 44 people
- Sponsor
- Assiut University
Pemphigus Vulgaris
CD19 CAR-T Therapy for Refractory Pemphigus Vulgaris
This is an investigator-initiated, single-center, single-arm, open-label exploratory clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of autologous CD19 CAR-T cell therapy in patients with…
- Trial name
- RESET-PV-CART (NCT07681388)
- Testing
- Autologous CD19 CAR-T cells
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Jinbo Chen
Hailey Hailey Disease
Efficacy of Guselkumab in Treating Hailey Hailey Disease
Hailey-Hailey disease (HHD) is a debilitating genetic skin disorder, affecting mainly body folds with erythema and painful erosions and blisters.
- Trial name
- NCT06651489
- Testing
- Guselkumab
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Rheumatoid Arthritis, Pemphigus Vulgaris
Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
This study will evaluate the safety and activity of AB-101 in combination with rituximab in B-cell associated autoimmune diseases where rituximab is currently FDA approved (e.g., Rheumatoid Arthritis (RA), Pemphigus Vulgaris…
- Conditions
- Rheumatoid Arthritis, Pemphigus Vulgaris, Granulomatosis With Polyangiitis, Systemic Lupus Erythematosus
- Trial name
- IRIS-RD-01 (NCT06581562)
- Testing
- AB-101, Rituximab, Cyclophosphamide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- IRIS Research and Development, LLC
Oral Lesions in Patients With Pemphigus Vulgaris
Comparison of the Efficacy of Clobetasol Propionate 0.05% Mouthwash, Photobiomodulation, and Their Combination in Managing of Oral Lesions in Patient With Pemphigus Vulgaris.
Pemphigus vulgaris (PV) is a chronic, potentially life-threatening autoimmune mucocutaneous disorder that significantly impairs patients' quality of life.
- Trial name
- NCT07641725
- Testing
- Clobetasol propionate 0.05% Mouthwash, diode laser for photobiomodulation, clobetasol propionate 0.05% mouthwash + photobiomodulation
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Pemphigus
A Clinical Study of B007 in the Treatment of Pemphigus.
The purpose of this study is to evaluate the efficacy and safety of B007 in subjects with pemphigus.
- Trial name
- NCT06454357
- Testing
- B007
- Where
- 12 sites in China
- Volunteers
- 132 people
- Sponsor
- Shanghai Jiaolian Drug Research and Development Co., Ltd
Inherited Epidermolysis Bullosa, Ichthyosis
FARD (RaDiCo Cohort) (RaDiCo-FARD)
The goal of this observational study is to conduct a prospective assessment of the individual Burden of 9 rare skin diseases to assess disability in the broadest sense of the term (psychological, social, economic and physical)…
- Conditions
- Inherited Epidermolysis Bullosa, Ichthyosis, Ectodermal Dysplasia, Incontinentia Pigmenti
- Trial name
- FARD (NCT05954416)
- Where
- 15 sites in France
- Volunteers
- 900 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy Adults
Statins Against Bushfire Smoke
The goal of this clinical trial is to test whether statins can protect the heart and brain from the biological stress and inflammatory responses caused by breathing bushfire smoke in healthy adult volunteers aged 18-64 years.
- Trial name
- SABS (NCT07462715)
- Testing
- Atorvastatin
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
Pemphigus Vulgaris
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)
A phase 1/2, open-label, safety and dosing study of autologous CART cells (desmoglein 3 chimeric autoantibody receptor T cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T cells [CABA-201]) in subjects with active…
- Trial name
- NCT04422912
- Testing
- DSG3-CAART, CABA-201
- Where
- 13 sites in United States
- Volunteers
- 40 people
- Sponsor
- Cabaletta Bio
Pemphigus Vulgaris
Low-level Laser Therapy on Oral Pemphigus Vulgaris Patients.
To assess the therapeutic efficacy of low level laser therapy on oral pemphigus vulgaris patients.
- Trial name
- NCT06971172
- Testing
- Low energy diode Laser, Medication
- Volunteers
- 22 people
- Sponsor
- Cairo University
Pemphigus, Dermatologic Disease
Comparison of a Personalized Maintenance Therapy With the Standard Treatment in Pemphigus
Pemphigus diseases are life-threatening chronic autoimmune blistering diseases characterized by split formation within the epidermis and surface-close epithelia accompanied by acantholysis.
- Trial name
- RITUX4 (NCT05898308)
- Testing
- RiTUXimab Injection
- Where
- 34 sites in France, Guadeloupe
- Volunteers
- 133 people
- Sponsor
- University Hospital, Rouen
Hailey Hailey Disease, Skin Diseases
A Study to Investigate Safety and Efficacy of KB111 for the Treatment of Hailey-Hailey Disease
An open-label study to evaluate the safety and efficacy of KB111 in pediatric and adult subjects with Hailey-Hailey Disease
- Conditions
- Hailey Hailey Disease, Skin Diseases, Lesion Skin
- Trial name
- HALITE-1 (NCT07717346)
- Testing
- KB111
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Krystal Biotech, Inc.
Pemphigus Vulgaris (PV)
Trichoscopy as a Monitoring Tool for Activity and Remission in Pemphigus Vulgaris: A Clinical Study Supported by Immunological Evaluation.
Pemphigus vulgaris (PV) is a potential life-threatening autoimmune bullous disorder presenting with multiple erosions and flaccid blisters that can involve both mucous membrane and skin.
- Trial name
- NCT06863454
- Testing
- Trichoscopy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Assiut University