Clinical trials: Penetrating Keratoplasty
Cytomegalovirus Endotheliitis
Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus Endotheliitis
The purpose of this study was to evaluate the outcomes of topical ganciclovir in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty at National Taiwan University hospital.
- Trial name
- NCT01359995
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Keratoconus, Corneal Dystrophies
Laser Assisted Procedures in Penetrating Keratoplasty
Laser- assisted procedures in penetrating keratoplasty (PK) are proposed to improve the surgical outcomes: minimally invasive procedures, improved biomechanical stability of the transplanted flap, reduction of rejection risks…
- Conditions
- Keratoconus, Corneal Dystrophies, Corneal Opacity
- Trial name
- NCT02173847
- Testing
- Penetrating keratoplasty, Femtosecond laser, Diode laser
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Ospedale Santo Stefano
Descemet's Stripping Automated Endothelial Keratoplasty
Pratical Assessment of DSAEK in the Management of Endothelial Decompensation Following Penetrating Keratoplasty
Reporting our anatomical and functional results and the possible complications of the first six Descemet's stripping endothelial keratoplasty (DSAEK) performed in our department secondary to endothelial decompensation after…
- Trial name
- MADE (NCT03687996)
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Graft Rejection
Pathogenetic Risk Factors for Corneal Graft Rejection
There are many predictors that may influence the development of corneal graft rejection after penetrating keratoplasty. In our study investigators analysed the results of keratoplasty and the risk factors for graft rejection.
- Trial name
- NCT06281587
- Testing
- penetrating keratoplasty
- Where
- Russia
- Volunteers
- 93 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Penetrating Keratoplasty
Topical FK506 (Tacrolimus) for Prevention of Immune Reactions Following Penetrating Keratoplasty
Background: Patients following allogeneic keratoplasty are treated with topical and frequently with systemic steroids to prevent immune reactions. Steroids are known to yield good results, but exert a wide range of side effects.
- Trial name
- NCT00463723
- Testing
- FK506 0.06% (eye drops)
- Sponsor
- University Hospital Freiburg
Irregular Astigmatism
Intrastromal Fresh Human Corneal Lenticule Implantation Using Smile Surgery for Treatment of Irregular Corneal Astigmatism After Penetrating Keratoplasty (New Approach)
The aim of the study is to present the effect of implanting intrastromal fresh corneal lenticule by SMILE surgery as a new method-approach to correct the corneal shape on purpose to reduce irregular astigmatism and increasing…
- Trial name
- NCT04987060
- Testing
- Intrastromal Fresh Human Lenticule Implantation
- Where
- Kosovo
- Volunteers
- 24 people
- Sponsor
- Eye Hospital Pristina Kosovo
Keratoconus
Treatment of Keratoconus With PALK Versus PK
The purpose of this study is to evaluate the visual results of patients with keratoconus treated with one of two techniques: penetrating keratoplasty (PK) vs. pachymetry and Excimer laser assisted lamellar keratoplasty (PALK).
- Trial name
- NCT02625467
- Testing
- Penetrating keratoplasty, Pachymetry and Excimer laser assisted lamellar keratoplasty, Treatment posterior to surgery
- Volunteers
- 28 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Refractive Surgery
Accelerated Versus Standard CXL in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty.
WHAT WAS KNOWN *Standard CXL is the common procedure for treating progressive corneal ectasia. Modifications of the standard protocol were introduces to reduce its complications especially long exposure to ultraviolet rays.
- Trial name
- NCT03791684
- Testing
- Cross linking
- Volunteers
- 111 people
- Sponsor
- Menoufia University
Keratoconus
Endothelial Cell Loss After Penetrating Keratoplasty
This work aimed at the assessment of corneal endothelial cell loss after toric ICL implantation for correction of myopia and astigmatism after penetrating keratoplasty.
- Trial name
- NCT04457063
- Testing
- PKP
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Alexandria University
Corneal Epithelial Defects After Ocular Surgeries
Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Topical insulin application has been proved recently to increase corneal reepithelization rate over diabetic animals. However, its effectiveness on corneal epithelial wound healing in patients who received pars planar vitrectomy…
- Trial name
- NCT01031888
- Testing
- Topical insulin eye drops, Conventional postoperative eye drops
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- National Taiwan University Hospital
Graft Rejection
Analysis of a Beneficial Effect of Prolonges Topical Steroid Treatment After Low-risk Penetrating Keratoplasty
PURPOSE: To assess the impact of duration of topical steroid treatment on the incidence of endothelial graft rejection following normal-risk penetrating keratoplasty (PK).
- Trial name
- NCT00450996
- Testing
- Topical Steroids
- Volunteers
- 400 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Glaucoma, Corneal Transplantation
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation.
- Conditions
- Glaucoma, Corneal Transplantation, Inflammation
- Trial name
- AH-Tears (NCT04339907)
- Testing
- Sampling of tears, Sampling of aqueous humor
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Keratoconus
Deep Anterior Lamellar Keratoplasty (DALK)
The purpose of this study is to report outcomes of deep anterior lamellar keratoplasty (DALK) using the big-bubble technique.
- Trial name
- DALK (NCT00887900)
- Testing
- Deep anterior lamellar keratoplasty (DALK), Penetrated keratoplasty
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital Oftalmologico de Brasilia
Corneal Neovascularization, Corneal Graft Failure
Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
The leading risk factor for corneal transplant rejection is abnormal blood vessel growth of the host bed. Vascular endothelial growth factor (VEGF) is thought to be a mediator of this corneal neovascularization (NV), therefore we…
- Trial name
- NCT01072357
- Testing
- Avastin® (bevacizumab), 0.9% NaCl & Refresh Liquigel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Reza Dana, MD
Corneal Neovascularization, Corneal Graft Failure
A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
The goal of this study is to investigate whether using bevacizumab (Avastin®) is both safe and effective at decreasing the likelihood of a high-risk corneal graft rejection.
- Trial name
- NCT01996826
- Testing
- Avastin® (bevacizumab), 0.9% NaCl & Refresh Liquigel
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Reza Dana, MD
Keratoconus, Fuchs' Endothelial Dystrophy
Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study
Immune rejection episodes after penetrating keratoplasty occur in 30% of patients and constitute one of the main factors reducing graft survival. They mainly occur during the first 18 months.
- Conditions
- Keratoconus, Fuchs' Endothelial Dystrophy, Congenital Hereditary Stromal Dystrophy of the Cornea
- Trial name
- IDEXACOR (NCT02834260)
- Testing
- Dexamethasone implant OZURDEX
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
CORNEAL OPACITY WITH POOR PROGNOSIS FOR CORNEAL TRANSPLANT
SINGLE PATIENT EXPANDED ACCESS OF A PROSPECTIVE, MULTICENTER CLINICAL TRIAL DESIGNED TO EVALUATE THE SAFETY AND PROBABLE BENEFIT OF THE KERAKLEAR NON-PENETRATING KERATOPROSTHESIS IN SUBJECTS WITH CORNEAL OPACITY WITH POOR PROGNOSIS FOR CORNEAL TRANSPLANT
This is for a "Single Patient Expanded Access" of an on-going study (IRB#2017-3526). In the on-going study, the maximum number of subject will be 35 subjects (35 eyes) will be implanted with the KeraKlear device and will be…
- Trial name
- NCT03812341
- Testing
- Experimental
- Where
- United States
- Sponsor
- University of California, Irvine
Fuch's Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media
The goal of this clinical trial is to compare the quality of corneal grafts cultured in a serum-free culture medium with a defined composition versus corneal grafts cultured in a standard serum supplemented culture medium…
- Trial name
- SFM (NCT00623584)
- Testing
- Corneal transplantation
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Klinikum Chemnitz gGmbH
Corneal Disease, Fuch's Dystrophy
Cornea Donor Study
The Cornea Donor Study (CDS) was designed as a prospective cohort study with the following objectives: To determine whether the graft-failure rate over a 5-year follow-up period following corneal transplantation is the same when…
- Conditions
- Corneal Disease, Fuch's Dystrophy, Pseudophakic Corneal Edema
- Trial name
- CDS (NCT00006411)
- Testing
- corneas assigned by donor age group
- Where
- United States
- Volunteers
- 1,090 people
- Sponsor
- National Eye Institute (NEI)