Clinical trials: Penicillin Allergy
Allergy
Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES)
Penicillin antibiotics are safe and inexpensive, and target selected bacteria rather than killing a broad range. Unfortunately, around 10% of the population are labelled as 'penicillin allergic'.
- Trial name
- PADLES (NCT03607734)
- Testing
- Amoxicillin
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Drug Hypersensitivity, Penicillin Allergy
Drug Challenges Without Prior Skin Testing
The investigators are conducting a prospective study to determine the safety and outcomes of placebo-controlled graded drug challenges without prior skin testing in patients with a low-risk history of antibiotic hypersensitivity…
- Conditions
- Drug Hypersensitivity, Penicillin Allergy, Antibiotic Allergy
- Trial name
- NCT03158831
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Penicillin Allergy
Penicillin Allergy in Shfayim Clinic
revising penicillin allergy in the medical records, by taking full medical history and giving a challange test, in order to imrove the medical records and treatment possibilities.
- Trial name
- NCT03499457
- Testing
- Amoxicillin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Allergy Penicillin
Evaluation of a Direct Oral Penicillin Challenge in a Rural Community
This study aims to evaluate the outcomes of a rural-DOC Pilot clinic which will be established in the Huntsville site of Muskoka Algonquin Healthcare.
- Trial name
- DOC (NCT06192277)
- Testing
- Screening, Low dose Penicillin, Standard dose Penicillin
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northern Ontario School of Medicine
Anaphylaxis
Desensitization of Human Mast Cells: Mechanisms and Potential Utility for Preventing Anaphylaxis
This is an open-label, single-center study of whether oral penicillin desensitization of healthy sensitive subjects results in allergen cross-desensitization of mast cells by skin testing and desensitization of peripheral blood…
- Trial name
- NCT00868842
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Penicillin Allergy
Safety and Efficacy of an Oral Penicillin Challenge in Low Risk Hospitalized Patients
Penicillin allergy is the most common drug allergy reported by patients. Approximately 10% of the population and 20% of inpatients carry a label of penicillin allergy.
- Trial name
- NCT04408508
- Testing
- Amoxicillin 250 MG
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Penicillin Allergy
Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting
Currently it is estimated that at least 25 million people in the United States are labeled as penicillin allergic although less than 1.5 million of these are truly allergic.
- Trial name
- NCT03702283
- Testing
- Penicillin Allergic Risk Stratification Best Practice Alert
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Penicillin Allergy
Evaluating the Feasibility of High-volume, Low-risk Penicillin Allergy De-labelling to Maximise Efficiency in a Resource-limited Setting
Plenty of studies have now established the safety of low-risk penicillin allergy de-labelling, but few have addressed how to organise de-labelling at the clinic level.
- Trial name
- De-Label Me (NCT06532448)
- Testing
- Single dose low-risk penicillin challenge
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Penicillin Allergy
Equivalency of Penicilloate Skin Test Reactivity Prepared by a Modified Alkaline Hydrolysis Technique
The primary objective of the study is to evaluate the equivalency of the skin test reactivity to penicilloate prepared by our new method of penicilloate preparation versus our old method of penicilloate preparation.
- Trial name
- NCT00589251
- Testing
- penicillin skin test
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Infection
Allergy Antibiotics And Microbial Resistance
ALBAMA study is designed to find out if the effects of Penicillin allergy assessment pathway (PAAP) intervention is on penicillin prescribing
- Trial name
- ALABAMA (NCT04108637)
- Testing
- penicillin allergy assessment pathway
- Where
- United Kingdom
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Penicillin Allergy, Antimicrobial Drug Resistance
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative…
- Conditions
- Penicillin Allergy, Antimicrobial Drug Resistance, AMR
- Trial name
- IMPAART (NCT07177690)
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Penicillin Allergy
Penicillin Allergy Delabeling Project
A investigational study to establish: 1. A validated cllinical pathway for delabeling declared Penicillin allergiy outside allergologic departments. 2.
- Trial name
- PenProv (NCT05090527)
- Testing
- Risk stratification
- Where
- 2 sites in Norway
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Allergy Penicillin
Alleged Drug Allergies in Military General Medicine: Patients' Experiences and Beliefs
This study focuses on the experience of the military patient reporting a suspected drug allergy, with its own specificities. Suspicions of drug allergies during a mission expose the doctor to difficulties.
- Trial name
- ALLMED (NCT06112470)
- Testing
- Interview
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Penicillin Allergy
Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic.
- Trial name
- NCT04441021
- Testing
- Penicillin Allergy Risk Stratification and Evaluation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Penicillin Allergy
Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams
This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.
- Trial name
- NCT00789217
- Testing
- Immediate skin test
- Where
- Thailand
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Maxillary Sinus Disease
Do Penicillin-allergic Patients Presents a High Risk of Sinus Lift Failure
This retrospective study aims to evaluate clinical histories to determine if there is a relationship between patients allergic to penicillin and sinus lift failure and the possible post-operative complications that may arise.
- Trial name
- NCT06504888
- Testing
- Penicillin
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Penicillin Allergy
The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal
Currently it is estimated that at least 25 million people in the United States are labeled as penicillin allergic although less than 1.5 million of these are truly allergic.
- Trial name
- NCT03702270
- Testing
- Penicillin Allergic Risk Stratification Best Practice Alert
- Where
- United States
- Volunteers
- 2,052 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Allergy Drug
De-labeling of Patients With False Diagnosis of Penicillin Allergy
The purpose of this study is to estimate the prevalence of penicillin allergy, evaluate the diagnostic value of the allergologic work-up used in the study, and the health effects of penicillin allergy.
- Trial name
- NCT03581604
- Testing
- Allergy work-up, Blood samples
- Where
- Norway
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Penicillin Allergy
Amoxicillin Challenge for Penicillin Allergy Diagnosis
False diagnosis of penicillin allergy are frequently reported, and have been proven detrimental to patients. Current guidelines for the assessment of drug allergies recommend that penicillin allergy be evaluated first with prick…
- Trial name
- Pen-VIE (NCT03757052)
- Testing
- Penicillin Skin Testing
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval