Clinical trials: Penicillin Allergy
Maxillary Sinus Disease
Do Penicillin-allergic Patients Presents a High Risk of Sinus Lift Failure
This retrospective study aims to evaluate clinical histories to determine if there is a relationship between patients allergic to penicillin and sinus lift failure and the possible post-operative complications that may arise.
- Trial name
- NCT06504888
- Testing
- Penicillin
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Bronchitis, Acute, Community-acquired Pneumonia
Multimodal Stewardship Programme to Improve Antibiotic Prescribing for Children With Lower Respiratory Tract Infections
Children with lower respiratory tract infection (LRTI) are still often prescribed antibiotics in ways that depart from national guidelines.
- Conditions
- Bronchitis, Acute, Community-acquired Pneumonia, Respiratory Tract Infections
- Trial name
- PRACTICE-LRTI (NCT07893834)
- Testing
- PRACTICE-LRTI multimodal antimicrobial stewardship programme
- Where
- Finland
- Volunteers
- 50,000 people
- Sponsor
- Tampere University
Penicillin Allergy, Penicillin Sensitivity
Inpatient Penicillin Allergy Delabeling Study
The study will identify pediatric patients 3-18 years old who have penicillin allergy label in the electronic medical record. Those who are identified will be stratified into no-risk, low-risk and high-risk category using a…
- Conditions
- Penicillin Allergy, Penicillin Sensitivity, Penicillin Reaction, Penicillin Intolerance
- Trial name
- NCT05020327
- Testing
- Graded Oral Amoxicillin Challenge, De-labelling in electronic medical record, Referral to Allergy Immunology/Retention of Allergy Label
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Penicillin Allergy
Penicillin Allergy Delabeling Project
A investigational study to establish: 1. A validated cllinical pathway for delabeling declared Penicillin allergiy outside allergologic departments. 2.
- Trial name
- PenProv (NCT05090527)
- Testing
- Risk stratification
- Where
- 2 sites in Norway
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Allergy Drug
De-labeling of Patients With False Diagnosis of Penicillin Allergy
The purpose of this study is to estimate the prevalence of penicillin allergy, evaluate the diagnostic value of the allergologic work-up used in the study, and the health effects of penicillin allergy.
- Trial name
- NCT03581604
- Testing
- Allergy work-up, Blood samples
- Where
- Norway
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Allergy Penicillin
Evaluation of a Direct Oral Penicillin Challenge in a Rural Community
This study aims to evaluate the outcomes of a rural-DOC Pilot clinic which will be established in the Huntsville site of Muskoka Algonquin Healthcare.
- Trial name
- DOC (NCT06192277)
- Testing
- Screening, Low dose Penicillin, Standard dose Penicillin
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northern Ontario School of Medicine
Penicillin Allergy, Aminopenicillin Allergy
The Diagnosis of Beta-lactam Hypersensitivity in Thailand
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand.
- Conditions
- Penicillin Allergy, Aminopenicillin Allergy, Beta Lactam Adverse Reaction
- Trial name
- NCT01667055
- Where
- Thailand
- Volunteers
- 500 people
- Sponsor
- Chulalongkorn University
Allergy
Negative Predictive Value and NIC of Beta-Lactam Antibiotics.
The researchers are trying to evaluate how much medication is required for allergy skin testing and to determine the likelihood that patients with a negative test truly don't have an allergy to the tested drug of skin testing to…
- Trial name
- NCT04126096
- Testing
- Skin Testing beta-lactams
- Where
- 2 sites in United States
- Volunteers
- 747 people
- Sponsor
- Mayo Clinic
Allergy Penicillin
Alleged Drug Allergies in Military General Medicine: Patients' Experiences and Beliefs
This study focuses on the experience of the military patient reporting a suspected drug allergy, with its own specificities. Suspicions of drug allergies during a mission expose the doctor to difficulties.
- Trial name
- ALLMED (NCT06112470)
- Testing
- Interview
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Hypersensitivity, Immediate, Hypersensitivity, Delayed
The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge
Whilst validated tools exist to enable inpatient penicillin assessment and de-labelling, limited evidence is available regarding the safety and efficacy in the outpatient clinic.
- Conditions
- Hypersensitivity, Immediate, Hypersensitivity, Delayed, Hypersensitivity Response
- Trial name
- PALACE (NCT04454229)
- Testing
- Direct oral penicillin challenge, Standard of care
- Where
- 6 sites in United States, Australia and 1 more
- Volunteers
- 382 people
- Sponsor
- Austin Health
Drug Allergy, Cephalosporin Allergy
Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in…
- Conditions
- Drug Allergy, Cephalosporin Allergy, Drug Hypersensitivity, Antibiotic Allergy
- Trial name
- DACAT (NCT06406114)
- Testing
- Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Adult Patients Who Declare an Allergy to Penicillin During Anaesthetic Consultation Without Any Allergy Work up That Could Confirm This Declaration, Good Comprehension of French Language
Assessment of the Applicability and Acceptability of an Algorithm to Guide the Prescription of 1st and 2nd Generation Cephalosporins as Part of Intraoperative Antibiotic Prophylaxis in Patients With a Declared Allergy to Penicillin
According to the Centers for Disease Control and Prevention (CDC), a surgical site infection (SSI) is an infection that occurs after surgery at the site where the surgery was performed.
- Trial name
- PROPHYLAL (NCT06067919)
- Testing
- decision tree for the choice of intraoperative antibiotic prophylaxis
- Where
- France
- Volunteers
- 275 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Penicillin Allergy, Pediatric Emergency Medicine
Oral Challenge in the Pediatric ED
Our primary objective was to demonstrate the feasibility of utilizing a novel penicillin allergy questionnaire in the PED to identify a low-risk group of patients who will complete an oral challenge in the PED to test for an…
- Trial name
- OPEN (NCT03404804)
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Medical College of Wisconsin
Penicillin Allergy
Evaluating the Feasibility of High-volume, Low-risk Penicillin Allergy De-labelling to Maximise Efficiency in a Resource-limited Setting
Plenty of studies have now established the safety of low-risk penicillin allergy de-labelling, but few have addressed how to organise de-labelling at the clinic level.
- Trial name
- De-Label Me (NCT06532448)
- Testing
- Single dose low-risk penicillin challenge
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Infection
Allergy Antibiotics And Microbial Resistance
ALBAMA study is designed to find out if the effects of Penicillin allergy assessment pathway (PAAP) intervention is on penicillin prescribing
- Trial name
- ALABAMA (NCT04108637)
- Testing
- penicillin allergy assessment pathway
- Where
- United Kingdom
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Drug Allergy, Penicillin Allergy
Provocation After Nurse-Directed Assessment (PANDA) Study
The study aims to evaluate the effectiveness and safety of a collaborative nurse-allergist approach in penicillin allergy delabeling services.
- Trial name
- PANDAS (NCT07127835)
- Testing
- Nurse-led penicillin allergy delabelling service, Allergist-led penicillin allergy delabelling service
- Where
- 4 sites in Hong Kong
- Volunteers
- 440 people
- Sponsor
- The University of Hong Kong
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Beta Lactam Adverse Reaction
B-lactam Databank Algorithm
Background: Antibiotic allergy constitutes a major health problem with serious medical and financial consequences when under- but also overdiagnosed. About one and a half million Belgians report having an allergy to penicillin.
- Trial name
- NCT06243380
- Where
- Belgium
- Volunteers
- 921 people
- Sponsor
- University Hospital, Antwerp
Penicillin Allergy, Antimicrobial Drug Resistance
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative…
- Conditions
- Penicillin Allergy, Antimicrobial Drug Resistance, AMR
- Trial name
- IMPAART (NCT07177690)
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Antibiotic Allergy
Penicillin Allergy Risk-Stratification and Delabeling of Low-Risk Patients
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic, however, recent studies have demonstrated that the majority of symptoms reported as an…
- Trial name
- NCT05561777
- Testing
- Physician-targeted CDS tool for PCN allergy delabeling
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center