Clinical trials: Percutaneous Coronary Intervention Patients
Myocardial Infarction
Safety and Efficacy Study of Adjunctive Antiplatelet Therapy Prior to Primary PCI in Patients With STEMI
Safety and efficacy of adjunctive antiplatelet therapy prior to primary percutaneous intervention (PCI) in patients with ST-Elevation Myocardial Infarction (STEMI)
- Trial name
- ERASE-MI (NCT00546260)
- Testing
- PRT060128 Potassium
- Where
- 31 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Coronary Syndrome
ARCANGELO (itAlian pRospective Study on CANGrELOr)
The Sponsor implemented a post-authorisation safety study (PASS), category 3, focused in Acute Coronary Syndrome, in order to collect information about the safety of cangrelor in the real clinical practice, evaluating the safety…
- Trial name
- ARCANGELO (NCT04471870)
- Where
- 30 sites in Italy
- Volunteers
- 1,005 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Coronary Artery Disease
Sort Out XI - Combo Stent Versus BioMatrix Alpha Stent
SORT OUT XI Comparison of Combo™ stent and BioMatrix Alpha™ stent in the treatment of unselected patients with ischemic heart disease.
- Trial name
- SORTOUTXI (NCT03952273)
- Testing
- PCI with BioMatrix Alpha™ stent, PCI with Combo™ stent
- Where
- 2 sites in Denmark
- Volunteers
- 3,141 people
- Sponsor
- Phillip Freeman
Sleep Hygiene
Promotion of Sleep for Patients Submitted to Percutaneous Intervention to Treat Heart Diseases
Patients undergoing treatment for heart disease through percutaneous interventions admitted to intensive care units often suffer from sleep deprivation, with multifactorial factors being the precursors of this problem.
- Trial name
- NCT04716491
- Testing
- Intervention to decrease disruptive sleep in patients undergoing percutaneous intervention to treat cardiac disorders admitted to the ICU: ear protector and eye mask.
- Volunteers
- 80 people
- Sponsor
- Hospital Sirio-Libanes
High-Risk Percutaneous Coronary Intervention
Impella ECP Study (ECP Study) and Impella ECP Continued Access Protocol
The Impella ECP Study is a prospective, multi-center, single-arm study evaluating the rate of major adverse cardiovascular and cerebrovascular events (MACCE) with the Impella ECP device in adult patients undergoing elective or…
- Trial name
- NCT05334784
- Testing
- Impella ECP
- Where
- 32 sites in United States
- Volunteers
- 856 people
- Sponsor
- Abiomed Inc.
Acute Coronary Syndrome
DAPT Strategy in HBR Patients Undergoing Complex PCI Following ACS: Second-Phase Beta Testing of a Patients Decision Aid
Among patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) and stent implantation, 17.5% are both at high bleeding risk (HBR) and have undergone complex PCI, which also places them at…
- Trial name
- BETA-DAPT (NCT07391358)
- Testing
- Patient decision aid to support shared decision-making between patients and clinicians
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Montreal Heart Institute
Atrial Fibrillation, Percutaneous Coronary Intervention
A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention
The primary purpose of this study is to evaluate the safety for 2 different rivaroxaban treatment strategies and one Vitamin K Antagonist (VKA) treatment strategy utilizing various combinations of dual antiplatelet therapy (DAPT)…
- Trial name
- PIONEER AF-PCI (NCT01830543)
- Testing
- rivaroxaban 2.5 mg, rivaroxaban 15 mg, rivaroxaban 10 mg
- Where
- 348 sites in United States, Argentina and 23 more
- Volunteers
- 2,124 people
- Sponsor
- Janssen Scientific Affairs, LLC
Percutaneous Coronary Intervention, Coronary Artery Disease (CAD)
Reversal of Heparin in Patients Undergoing Percutaneous Coronary Intervention (PCI)
The study investigates the safety and efficacy of PMX-60056 for the Reversal of Heparin in Patients Undergoing Percutaneous Coronary Intervention (PCI)
- Conditions
- Percutaneous Coronary Intervention, Coronary Artery Disease (CAD), Angioplasty
- Trial name
- NCT01312935
- Testing
- PMX-60056
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- PolyMedix, Inc.
Coronary Disease, Coronary Stenosis
A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease
The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in…
- Trial name
- FAME 3 (NCT02100722)
- Testing
- FFR guided PCI, CABG, Resolute Integrity Stent
- Where
- 46 sites in United States, Australia and 14 more
- Volunteers
- 1,500 people
- Sponsor
- Stanford University
Biomarkers, ST Segment Elevation Myocardial Infarction
Biomarkers for Risk Stratification After STEMI
Despite modern reperfusion strategies, myocardial infarction leads to deleterious processes resulting in left ventricular remodelling (LVR) and heart failure (HF). Several biomarkers i.e.
- Conditions
- Biomarkers, ST Segment Elevation Myocardial Infarction, Primary Percutaneous Coronary Intervention, Heart Diseases
- Trial name
- NCT03735719
- Where
- Poland
- Volunteers
- 136 people
- Sponsor
- Medical University of Warsaw
Myocardial Infarction
Left Atrial Appendage Closure Compared to Standard Antiplatelet Therapy in Patients With AF Who Underwent PCI
The objective of Left atrial appendage closure compared to standard antiplatelet therapy in patients with AF who underwent percutaneous coronary intervention (LLA-PCI) study is to evaluate the safety and efficacy of implantation…
- Trial name
- NCT02492230
- Testing
- Left Atrial Appendage Closure Device (Watchman), Warfarin
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Percutaneous Coronary Intervention, No-reflow Phenomen
The RESTORE-SIRIO Randomized Controlled Trial
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion strategy for treating acute ST-segment elevation myocardial infarction (STEMI).
- Conditions
- Percutaneous Coronary Intervention, No-reflow Phenomen, Acute ST-segment Elevation Myocardial Infarction
- Trial name
- RESTORE-SIRIO (NCT02405130)
- Testing
- intracoronary epinephrine, no intracoronary epinephrine
- Where
- Germany
- Sponsor
- Heinrich-Heine University, Duesseldorf
STEMI, Myocardial Reperfusion Injury
Effect of Remote Ischaemic Conditioning on Clinical Outcomes in STEMI Patients Undergoing PPCI (CONDI2/ERIC-PPCI)
The purpose of this study is to determine whether remote ischemic conditioning can reduce cardiac death and hospitalization for heart failure at 12 months in patients presenting with a ST-elevation myocardial infarction and…
- Trial name
- NCT02342522
- Testing
- Remote ischemic conditioning, Control
- Where
- 35 sites in Denmark, Serbia and 2 more
- Volunteers
- 5,413 people
- Sponsor
- University College, London
Heart Failure, Revascularization
Percutaneous Coronary RevascularizatiOn VERsus Coronary-Artery Bypass Grafting for Multivessel Disease in Patients With Left Ventricular Dysfunction (PROVERB)
A short description, 5000 characters Ischemic cardiomyopathy related to coronary artery disease is currently the leading cause of heart failure.
- Trial name
- PROVERB (NCT05532631)
- Testing
- Percutaneous coronary intervention, Coronary artery bypass grafting
- Where
- France
- Volunteers
- 1,040 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST Elevation Myocardial Infarction
Aggressive hydraTion in Patients With ST -Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention to prevenT Contrast-Induced Nephropathy
To compare the efficacy of 2 different hydration strategies, hydration according to clinical guideline and adequate hydration, on contrast-induced nephropathy in patients with STEMI undergoing primary PCI to investigate the…
- Trial name
- ATTEMPT (NCT02067195)
- Testing
- Receiving hydration with a 1 mL/kg bolus of intravenous isotonic saline (0.9% sodium chloride), 3 mL/kg.hour bolus of intravenous isotonic saline (0.9% sodium chloride)
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Guangdong Provincial People's Hospital
Percutaneous Coronary Intervention, Multivessel Coronary Artery Disease
Residual Inflammatory Risk-Guided colcHicine in Elderly Trial
The goal of this clinical trial is to compare low-dose colchicine (0.5 mg Once Daily) with no specific intervention in selected elderly patients (60-80 years old) with residual inflammatory risk (hs-CRP≥ 2mg/L) and multivessel…
- Conditions
- Percutaneous Coronary Intervention, Multivessel Coronary Artery Disease, Elderly Patients, C-Reactive Protein
- Trial name
- RIGHT (NCT06025071)
- Testing
- colchicine
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
ST Elevation (STEMI) Myocardial Infarction, Non ST Elevation Myocardial Infarction (NSTEMI)
Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With Acute Coronary Syndrome
This study will evaluate clinical characteristics, frailty, and predictors of prognosis in patients aged 75 years and older who are hospitalized with acute coronary syndrome (ACS).
- Conditions
- ST Elevation (STEMI) Myocardial Infarction, Non ST Elevation Myocardial Infarction (NSTEMI), Unstable Angina Pectoris
- Trial name
- NCT07366684
- Testing
- Percutaneous Coronary Intervention (PCI), Conservative Medical Therapy
- Where
- Serbia
- Volunteers
- 550 people
- Sponsor
- Clinical Center Niš
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), High Bleeding Risk
Genotype-Guided Abbreviated DAPT Versus Un-Guided De-escalation Therapy in Patients With ACS and HBR
The aim of this study is to assess the safety and efficacy of the CYP2C19 genotype-guided abbreviated dual antiplatelet therapy (DAPT) strategy versus the un-guided stepwise intensity de-escalation of DAPT strategy in patients…
- Trial name
- GUIDE-HBR (NCT06763744)
- Testing
- P2Y12 antagonist monotherapy, clopidogrel + aspirin
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Samsung Medical Center
Hypertension, Coronary Arterial Disease
Comparative Effectiveness of Dual Antihypertensive Regimens in Patients After Percutaneous Coronary Intervention
This prospective randomized open-label study aims to compare the effectiveness of two dual antihypertensive therapy regimens in patients with arterial hypertension and coronary artery disease after elective percutaneous coronary…
- Conditions
- Hypertension, Coronary Arterial Disease, Percutaneous Coronary Intervention
- Trial name
- EDAM (NCT07683585)
- Testing
- Losartan + Hydrochlorothiazide, Amlodipine + Azilsartan
- Where
- Russia
- Volunteers
- 207 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Atrial Fibrillations, Heart Valve Prostheses
What is the Optimal antiplatElet and Anticoagulant Therapy in Patients With Oral Anticoagulation Undergoing revasculariSaTion 2.
The optimal antithrombotic therapy for patients with atrial fibrillation (AF) with a CHA2DS2-VASc score ≥1 with concomitant acute coronary syndrome (ACS) or revascularisation by percutaneous coronary intervention (PCI) with…
- Conditions
- Atrial Fibrillations, Heart Valve Prostheses, Acute Coronary Syndromes, Coronary Artery Diseases
- Trial name
- WOEST 2 (NCT02635230)
- Testing
- Combination of chronic oral anticoagulation and a P2Y12 inhibitor with or without aspirin.
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 2,200 people
- Sponsor
- R&D Cardiologie