Clinical trials: Perforated Diverticulitis
Acute Diverticulitis
Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study)
Laparoscopic peritoneal lavage (LPL) has recently been emerging as an effective alternative to laparoscopic sigmoidectomy (LS) in patients with complicated acute diverticulitis (CAD) (Modified Hinchey's classification grade II…
- Trial name
- STELLA (NCT03008707)
- Testing
- Laparoscopic Peritoneal Lavage
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Complicated Diverticulitis, Acute Diverticulitis
AIDE: Decision Support for Anastomosis or Colostomy in Emergency Surgery for Complicated Acute Diverticulitis
The AIDE/OBS study is a multicenter, observational, non-interventional study designed to collect standardized clinical, radiological, intraoperative visual, and surgical reasoning data from adult patients undergoing non-elective…
- Conditions
- Complicated Diverticulitis, Acute Diverticulitis, Peritonitis, Perforated Diverticulitis
- Trial name
- AIDE/OBS/2025 (NCT07651072)
- Testing
- Primary anastomosis, Hartmann's procedure
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele Roma
Perforated Diverticulitis
Laparoscopic Peritoneal Lavage or Resection for Generalised Peritonitis for Perforated Diverticulitis
The first objective (LOLA) of this integrated trial is to determine whether laparoscopic lavage leads to better clinical outcomes compared to sigmoidectomy in patients with perforated diverticulitis with purulent peritonitis in…
- Trial name
- Ladies (NCT01317485)
- Testing
- Laparoscopic lavage and drainage, Sigmoidectomy with primary anastomosis, Sigmoidectomy with end-colostomy
- Where
- 41 sites in Belgium, Netherlands
- Volunteers
- 283 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diverticulitis, Diverticulitis Colon
Management and Evolution of Acute Diverticulitis With Pericolic Free Gas
The severity of diverticulitis is usually graded with the use of modified Hinchey Criteria. However, there is a condition often seen in the CT scan that is not included in this classification itself; 1-2 pericolic bubbles but no…
- Conditions
- Diverticulitis, Diverticulitis Colon, Diverticulitis; Perforation, Bowel, Diverticulitis of Sigmoid
- Trial name
- ADiFas (NCT04311385)
- Testing
- CT imaging
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Diverticular Perforation, Open Abdomen
Damage Control Surgery Over the World in Acute Diverticulitis (DACOSAD)
To analyze the possible benefit of damage control surgery by performing bowel resection, open abdomen, and delayed anastomosis in the treatment of Hinchey III or IV diverticulitis.
- Trial name
- DACOSAD (NCT06428370)
- Testing
- Damage Control Surgery
- Where
- 9 sites in Chile, Italy
- Volunteers
- 300 people
- Sponsor
- Link Campus University
Peritonitis Caused by Perforated Left-sided Colon Diverticulitis
Hartmann vs R/A in Peritonitis by Perforated Diverticulitis
This prospective randomized trial is to prove the equivalence of primary sigmoid resection with end colostomy(Hartmann)(GROUP A) and primary sigmoid resection and immediate anastomosis with diverting stoma (GROUP B)with regard to…
- Trial name
- NCT01239927
- Testing
- Primary sigmoid resection with end colostomy (Hartmann), Primary sigmoid resection and immediate anastomosis with diverting stoma (PRA)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Diverticulitis
Scandinavian Diverticulitis Trial
The purpose of this study is to determine whether laparoscopic lavage changes the rate of severe complications in patients with acute perforated diverticulitis who traditionally are treated with primary resection.
- Trial name
- SCANDIV (NCT01047462)
- Testing
- Surgery for acute perforated diverticulitis
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- University Hospital, Akershus
Appendicitis, Cholecystitis
Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection
This is a phase 3b/4 randomized, open-label, comparative, multicenter study of the safety and efficacy of tigecycline to ceftriaxone sodium plus metronidazole in hospitalized subjects with cIAI (Complicated Intra-Abdominal…
- Conditions
- Appendicitis, Cholecystitis, Cross Infection, Diverticulitis
- Trial name
- NCT00195351
- Testing
- tigecycline, ceftriaxone sodium + metronidazole
- Where
- 66 sites in United States, Argentina and 4 more
- Volunteers
- 467 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Perforated Diverticulitis
The Damage Control Strategy for the Treatment of Perforated Diverticulitis of the Sigmoid Colon With Diffuse Peritonitis
The best approach for the treatment of perforated diverticulitis of the sigmoid colon is still under debate. Concurrent techniques are 1) resection with primary colorectal anastomosis with or without additional loop ileostomy; 2)…
- Trial name
- NCT04220840
- Testing
- Damage control strategy
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Städtisches Klinikum München GmbH
Diverticular Disease of Colon, Diverticulitis, Colonic
Evaluation of Laparoscopic Peritoneal Lavage for Perforated Diverticulitis: A National Registry - Based Study
The goal of this observational study is to study the emergency surgical treatment of diverticular disease in Sweden outside clinical trials.
- Conditions
- Diverticular Disease of Colon, Diverticulitis, Colonic, Peritonitis, Gastrointestinal Diseases
- Trial name
- NCT05893095
- Volunteers
- 52,863 people
- Sponsor
- Uppsala University Hospital
Surgery, Diverticulitis
Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation
The purpose of this multi-center randomized trial is to identify any differences in the complication rates of patients undergoing Hartmann's (end colostomy) versus Primary Anastomosis (with defunctioning ileostomy) for left-sided…
- Conditions
- Surgery, Diverticulitis, Neoplasms, Postoperative Complications
- Trial name
- ColonPerfRCT (NCT01233713)
- Testing
- Hartmann's operation, Primary anastomosis
- Where
- 4 sites in Switzerland
- Volunteers
- 62 people
- Sponsor
- University of Zurich
Perforated Diverticulitis
A National Study of Clinical Results After Emergency Operation for Perforated Diverticulitis
The aim of this study is to evaluate clinical results and effect on health and well-being in patients operated for perforated diverticulitis with purulent peritonitis by laparoscopic lavage in Sweden when used outside of…
- Trial name
- LapLav (NCT03332550)
- Testing
- Laparoscopic lavage, Colon resection
- Where
- Sweden
- Volunteers
- 669 people
- Sponsor
- Sahlgrenska University Hospital
Peritonitis
Role of Protective Stoma After Primary Anastomosis for Generalized Peritonitis Due to Perforated Diverticulitis
This study is designed to be a multicentre, prospective, comparative, randomised trial, evaluating the efficacy of two surgical strategies for the treatment of generalised peritonitis due to perforated diverticulitis.
- Trial name
- DIVERTI2 (NCT04604730)
- Testing
- Primary anastomosis without protective stoma, Anastomosis with protective stoma
- Where
- 20 sites in France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Rouen
Diverticulitis, Surgical Site Infection
Surgical Site Infection Outcomes in Natural Orifice Intracorporeal Anastomosis and Extraction (NICE) Procedure - The NICE Trial
The goal of this observational study is to learn if a new surgical technique, called the NICE procedure, is as safe as standard methods for treating benign left-sided colon and rectal diseases in adults.
- Conditions
- Diverticulitis, Surgical Site Infection, Surgical Site Infections, Colorectal Surgery
- Trial name
- NCT06957236
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Methodist Hospital Research Institute
Perforated Diverticulitis
Characteristics of Abdominal Fluid in Patients With Diverticulitis Hinchey III or IV
Perforated diverticulitis of the colon can be complicated by peritonitis, either purulent or fecal. Both are life threatening conditions requiring emergency surgery.
- Trial name
- NCT04427891
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Peritonitis
Primary vs. Secondary Anastomosis for Hinchey Stage III-IV Diverticulitis a Prospective Randomized Trial
This study compares primary resection with anastomosis and Hartmann's procedure in an adult population with acute perforated colonic diverticulitis (Hinchey Stage III and IV) METHODS: The primary end point was postoperative…
- Trial name
- DIVERTI (NCT00692393)
- Testing
- Hartmann intervention, Protected anastomosis resection
- Where
- France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Rouen
Diverticulitis
LapLAND Laparoscopic Lavage for Acute Non-Faeculant Diverticulitis
The aim of the study is to compare patient outcome following standard of care (Hartmann's or resection with anastomosis and defunctioning stoma) and a 'new therapy' (laparoscopic lavage alone) for the treatment of acute…
- Trial name
- LapLAND (NCT01019239)
- Testing
- Laparoscopic Washout, Hartmann's Procedure/ Primary Resection and Anastomosis
- Where
- Ireland
- Volunteers
- 300 people
- Sponsor
- St Vincent's University Hospital, Ireland
Damage Control for Perforated Diverticulitis
Trial on Damage Control Surgery for Perforated Diverticulitis With Generalized Peritonitis
Damage control surgery (DCS) with abdominal negative pressure therap (NPT) and delayed anastomosis creation in patients with perforated diverticulitis and generalized peritonitis was established at our Institution in 2006 and has…
- Trial name
- Damage Control (NCT04034407)
- Testing
- Damage control surgery
- Volunteers
- 22 people
- Sponsor
- Medical University Innsbruck