Clinical trials: Perfusion
Sepsis
Immune Activation, Hypoxia and Vasoreaction in Sepsis of Pulmonary Versus Abdominal Origin
Sepsis remains a common entity in critical care patients with remarkable mortality. Pulmonary and abdominal infections (with subsequent sepsis) are the most common in the ICU.
- Trial name
- NCT01530932
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
End Stage Heart Failure
Impact of LVAD Implantation on Micro- and Macrovascular Function
End stage heart failure is characterized by a critical inability of the heart to meet the organism's blood demand even under resting conditions.
- Trial name
- LVAD (NCT02174133)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Anesthesia, Intraocular Pressure
Intraocular Pressure, Optic Nerve Sheath Diameter and Optic Perfusion Pressure of Minimal Low and High-Flow Anesthesia
The aim of this clinical trial is to determine the effect of minimal low-flow versus high-flow anesthesia on intraocular pressure (IOP) by non-contact tonometry, optic nerve sheath diameter (ONSD) by USG and optic perfusion…
- Conditions
- Anesthesia, Intraocular Pressure, Nephrolithiasis
- Trial name
- NCT06684704
- Testing
- minimal and high flow anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Ketosis, Ketonemia
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects
This is a randomized, placebo-controlled, double-blinded crossover design. Fifteen healthy subjects will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid.
- Trial name
- KETO (NCT05980858)
- Testing
- Beta-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Congenital Heart Disease
Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements
The purpose of this study is to implement and externally validate an inpatient ML algorithm that combines pulse oximetry features for critical congenital heart disease (CCHD) screening.
- Trial name
- NCT05637814
- Testing
- SpO2/PIx Measurement and ML Algorithm
- Where
- 3 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Echolocation
Effect of Bile Acids on the Secretion of Satiation Peptides in Humans
The purpose of this study is do determine the functional significance of the G protein-coupled receptor TGR5 in the secretion of GI satiation peptides by using natural bile acids and oleanolic acid (triterpenoid compound of plant…
- Trial name
- NCT01674946
- Testing
- saline, bile acid (CDCA, chenodeoxycholic acid), oleanolic acid
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Brain Ischemia
Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study
Postural changes are commonly used as therapeutic maneuver to enhance or reduce cerebral perfusion. For instance, in acute stroke, the patient can be positioned in head down tilt position so as to increase perfusion of cerebral…
- Trial name
- PerfIRMAVC (NCT02912546)
- Testing
- MRI
- Where
- Martinique
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Coronary Artery Disease, Myocardial Perfusion
E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion
E-cigarettes deliver nicotine by creating an aerosol of ultrafine particles. Many questions remain about the size and composition and especially about the potential toxicity of these particles.
- Trial name
- NCT02612701
- Testing
- Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Healthy Adults
Myocardial Blood Volume Measurement by Real-Time Myocardial Perfusion Echocardiography Correlates to Myocardial Compressibility by Cardiac Magnetic Resonance Imaging in Healthy Subjects
This study is being done to find out the normal amount of blood within the heart muscle and the variations in this blood flow between a cardiac MRI and TTE.
- Trial name
- NCT04724304
- Testing
- Real-Time Myocardial Echocardiography (RTMPE), Magnetic resonance image (MRI)
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Coronary Artery Disease, Myocardial Ischemia
Validation of a Single Rest-Stress Imaging Protocol for Myocardial Perfusion Imaging
We propose a single-scan two-injection myocardial perfusion imaging protocol using ammonia. Subjects will undergo single-scan two-injection imaging as well as regular stress single-scan single-injection protocol and the…
- Trial name
- NCT03265535
- Testing
- Single-Scan Two-Injection Protocol
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Peripheral Arterial Disease
Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease
The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the response to interventional…
- Trial name
- NCT06952543
- Testing
- Ultrasound Imaging
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Central Sympathetic Nervous System Diseases
Role of Sympathetic Activation in Ischemia Reperfusion Injury
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote…
- Trial name
- NCT04479813
- Testing
- Moxonidine 0.2 MG
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Royal Perth Hospital
Acute Myeloid Leukemia
Bone Marrow Angiogenesis in Acute Myeloid Leukemia - Evaluated by Dynamic Contrast Enhanced Magnetic Resonance (MR) Image
In malignant or neoplastic disease, angiogenesis is defined as the generation of new capillaries from preexisting blood vessels, e.g. by sprouting or by intusseption.
- Trial name
- NCT00172562
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus
The Aim is to Estimate the Total Amount of Insulin-producing Cells in the Pancreas by MRI.
Assess pancreatic beta cell function using MR imaging.
- Trial name
- NCT00280085
- Testing
- MR imaging, Glucose clamp, Arginine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Pfizer
Biological Aging
Effects of Phytonutrients Upon Muscle Perfusion in Response to Feeding
This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.
- Trial name
- NCT03213340
- Testing
- Catechin Cohort 1, Curcuminoid Cohort 2, Flavonoid Cohort 3
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Patent Ductus Arteriosus, Persistent Pulmonary Hypertension of the Newborn
Plethismographic Perfusion Index in Neonates
Photoplethismography will be measured and compared in newborns suffering from patent ductus arteriosus and normal controls.
- Trial name
- NCT02380040
- Testing
- PPG
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Peripheral Arterial Disease
Feasibility Study to Evaluate Therapeutic Ultrasound (TUS) to Acutely Increase the Perfusion in Peripheral Arterial Disease (PAD)
This study is evaluating whether a therapeutic ultrasound device can improve symptoms in the leg of peripheral arterial disease (PAD) patients 65 years of age and over.
- Trial name
- Waltz (NCT05888740)
- Testing
- VibratoSleeve Therapeutic Ultrasound Device
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vibrato Medical, Inc.
Cerebral Perfusion Pressure, Vasopressor Agents
Physiologic Study of Cerebral Perfusion
The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients
- Conditions
- Cerebral Perfusion Pressure, Vasopressor Agents, Shock, Magnetic Resonance Imaging (MRI), Functional
- Trial name
- NCT02744625
- Testing
- Higher doses of vasopressor therapy for a MAP of 75 mmHg, Lower doses of vasopressor therapy for a MAP of 65 mmHg, Propofol for light sedation
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Perfusion; Complications
Microdosing ICG for Serial Colonic Perfusion Study During Surgery
using microdosing of ICG vs regular dosing of ICG for perfusion assessment during surgery
- Trial name
- NCT06254833
- Testing
- micro dosing of ICG
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shanglei Liu
Cystic Fibrosis
Non-contrast Lung Perfusion Mapping Applied for New Insights in Cystic Fibrosis
Cystic fibrosis (CF) results in the thickening of mucus in the lungs and other organs due to dysfunction of a transmembrane conductance protein.
- Trial name
- NCT04467957
- Testing
- Initiation of CFTR Modulator, Hyperpolarized Xenon 129
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati