Clinical trials: Perfusion
Peripheral Arterial Disease, Diabetes Mellitus
The Use of HOVR Technology for Assessment of Blood Associated Parameters
Feasibility, usability and safety clinical study that is aimed at testing of the non-invasive VOTIS PedCheck system for measurement of changes in absorption of light in order to derive changes in perfusion and oxygen levels in…
- Trial name
- NCT05921461
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Votis Subdermal Imaging Technologies LTD
Movement Artifacts During SpO2 Measurements, Reduced Perfusion During SpO2 Measurements
SpO2 Measurement Depending on Different Pulse Oximeter Averaging Time Settings
The aim of this study is to characterize the noise in the SpO2 signal depending on different pulse oximeter averaging time settings.
- Trial name
- NCT04933773
- Testing
- Movement artifact - knocking, Movement artifact - tremor, Artifact - ambient light
- Where
- Czechia
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
The GLP-1-mediated Gut-kidney Axis
Acute Effects of GLP-1 on Renal Hemodynamics
This study investigates the hypothesis, that GLP-1's suppression of ANG II and natriuretic action increase medullary perfusion and decrease oxygen consumption, leading to higher tissue oxygenation.
- Trial name
- GLP1RRBF (NCT04337268)
- Testing
- Glucagon-Like Peptide 1, saline 0.9%
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiomyopathy, Dilated, Prognosis
Cardiac Magnetic Resonance-Clinical Prediction Model-Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is a common and serious heart disease characterized by left ventricular enlargement and impaired pumping function, with adverse prognosis (including heart failure, arrhythmia, heart-related…
- Conditions
- Cardiomyopathy, Dilated, Prognosis, Magnetic Resonance Imaging, Cardiac, Death, Sudden, Cardiac
- Trial name
- MPS-CMR-DCM (NCT07527715)
- Testing
- left ventricular ejection fraction
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital
Hypertension, Chronic Kidney Disease
Accuracy of 1.5 T Versus 3 T Magnetic Resonance Arterial Spin Labeling to Measure Renal Blood Flow
In this study we want to compare the accuracy of two methods to measure renal perfusion by MRI spin labelling technique: the first measurement done with the 1.5 T MRI versus the second one obtained with the 3.0 T MRI (Siemens MRI…
- Trial name
- NCT02746549
- Testing
- renal perfusion
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Peripheral Arterial Disease
Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease
The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the response to interventional…
- Trial name
- NCT06952543
- Testing
- Ultrasound Imaging
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chest Pain, Sickle Cell Anemia
Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia
Sickle cell anemia is the most common genetic disease affecting African-Americans. About 1 in every 1000 African-Americans has the disease and 1 in every 12 carry the genes that could be passed on to their children.
- Trial name
- NCT00001716
- Testing
- Nitric Oxide, Nitroglycerin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pressure Ulcer
Peripheral Perfusion and Oxygenation in Areas of Risk of Skin Integrity Impairment Exposed to Pressure Patterns.
Objectives: 1. To analyze the changes in peripheral tissue oxygenation in tissues subjected to different pressure regimes in healthy humans. 2.
- Trial name
- POTER-DIC (NCT02736838)
- Testing
- tcpO2, Laser Doppler
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Peripheral Arterial Disease
Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease (PAD)
Contrast ultrasound is a technique that can quantify blood flow in the tissues of the body by ultrasound detection of microbubble contrast agents that behave in the circulation similar to red blood cells.
- Trial name
- NCT01377649
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cystic Fibrosis
Non-contrast Lung Perfusion Mapping Applied for New Insights in Cystic Fibrosis
Cystic fibrosis (CF) results in the thickening of mucus in the lungs and other organs due to dysfunction of a transmembrane conductance protein.
- Trial name
- NCT04467957
- Testing
- Initiation of CFTR Modulator, Hyperpolarized Xenon 129
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hemorrhage, Hemodynamic Instability
Consortium for Optimized Integration of Bio-Artificial Blood Components for Adaptive Resuscitation Therapy
There is need for a whole blood analog for use when banked blood is unavailable or undesirable. In civilian trauma, hemorrhage accounts for ~ 35% of pre-hospital deaths; moreover, ~ 20% of military casualties are in hemorrhagic…
- Trial name
- CONCERT (NCT05756426)
- Testing
- Prospective
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Ischemia/Reperfusion Injury
Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury. Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against…
- Trial name
- NCT00526695
- Testing
- Sevoflurane (Preconditioning)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Coronary Microvascular Disease, Coronary Artery Disease
A Non-invasive Index of Microciculatory Resistance
Coronary artery microvascular disease (CMVD) lacks reliable and non-invasive quantitative diagnosis methods. Improving coronary microcirculation has become one of the main goals of coronary heart disease treatment.
- Trial name
- NCT04554004
- Testing
- CCTA, CT-MPI, DSA, FFR
- Where
- China
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Glymphatic System, Neurodegeneration
Acute Effects of Vigorous-intensity Aerobic Exercise on Glymphatic Flow in Healthy Adults
This study investigates changes in glymphatic flow in the brain acutely after vigorous-intensity steady-state aerobic exercise. Twenty subjects (10 male and 10 female) perform 25 minute submaximal cycle ergometry exercise and the…
- Trial name
- GLYMREG (NCT04255758)
- Testing
- Cycle Ergometer Exercise
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Pantothenate Kinase-associated Neurodegeneration (PKAN)
Brain Perfusion in Pantothenate Kinase-associated Neurodegeneration (PKAN)
The purpose of this study is to learn whether blood flow in the brain is normal in people with pantothenate kinase-associated neurodegeneration (PKAN).
- Trial name
- NCT01838018
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Susan J. Hayflick
Vascular Diseases
Quantitative Perfusion Imaging Using Contrast Enhanced Perfusion Ultrasound, MRI and Perfusion Angiography
Peripheral Arterial Disease is the narrowing and blocking of the blood vessels that supply the legs and feet. It is a common and progressive condition that affects patients of all backgrounds and genders and is more common in…
- Trial name
- QPiPAD (NCT06103708)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University College, London
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Peripheral Perfusion
Modified Allen's Test and Peripheral Perfusion Index
to detect the relation between results of the peripheral perfusion index and modified Allen's test.
- Trial name
- NCT04043481
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assiut University
Peripheral Arterial Disease, Tissue Perfusion
Perfusion Assessment Using BOLD MRI and PBV in Endovascular Treatment of Peripheral Arterial Occlusive Disease
Current assessment of lower limb ischemia cannot reflect the location and degree of ischemia. Tissue perfusion assessment was used in the diagnosis and treatment of lower limb ischemia in this project, and the quantitative…
- Trial name
- NCT05045365
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Peripheral Arterial Disease
Functional MRI of the Lower Extremities
In this project, the investigators propose to use high-resolution magnetic resonance imaging (MRI) to measure blood perfusion in different groups of calf muscle.
- Trial name
- NCT03423316
- Testing
- Supervised exercise therapy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital