Clinical trials: Periampullary Adenocarcinoma
Gastric Outlet Obstruction
Enteral Anastomosis for the Treatment of Gastric Outlet Obstruction: A Randomized Controlled Study Comparing Endoscopic Versus Surgical Gastrojejunostomy
Gastric outlet obstruction (GOO) occurs commonly in malignancies involving the periampullary region (cancers originating in the head of the pancreas, duodenum, bile duct, or ampulla) or the distal stomach.
- Trial name
- EAT-GO (NCT05561907)
- Testing
- Surgical gastrojejunostomy (SGJ), Endoscopic gastrojejunostomy (EGJ)
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Northwell Health
Pancreatic Cancer
Radiation Therapy Plus Gadolinium Texaphyrin in Treating Patients With Cancer of the Pancreas That Cannot Be Removed by Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as gadolinium texaphyrin may make the tumor cells more sensitive to radiation therapy.
- Trial name
- NCT00003798
- Testing
- motexafin gadolinium, radiation therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Saleh's Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate)
This study investigates the safety and efficacy of injecting N-butyl-2-cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the pancreaticojejunostomy (PJ)…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07132541)
- Testing
- Pancreatic parenchymal injection of N-butyl-2-cyanoacrylate(Histoacryl®)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Pancreatic Ductal Adenocarcinoma, Periampullary Cancer
Escitalopram to Placebo in Patients With Localized Pancreatic Cancer
Use of antidepressants for participants with localized pancreatic and periampullary cancer receiving neoadjuvant therapy.
- Trial name
- NCT05289830
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Cancer, Periampullary Cancer
Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas
This is a single-center, randomized controlled trial comparing the efficacy of pancreaticojejunostomy with modified N-butyl-2-cyanoacrylate(Glubran® 2) versus standard pancreaticojejunostomy without cyanoacrylate in preventing…
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Duodenal Cancer, Cholangiocarcinoma
- Trial name
- NBCA-MS (NCT07155525)
- Testing
- Pancreaticojejunostomy with Modified N-Butyl-2-Cyanoacrylate (Glubran® 2), Standard(duct-to-mucosa) Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Minia University
Pancreas Cancer, Pancreas Neoplasm
The Role of the Human Microbiome in Patients After Pancreatic Resection.
The goal of this observational study is to classify patients that undergo pancreatic resection for presumed pancreatic or periampullary malignancy into high and low risk groups for postoperative complications based on…
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Adenocarcinoma, Periampullary Cancer
- Trial name
- MiPac (NCT06381882)
- Testing
- Pancreatic resection
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- St. Antonius Hospital
Pancreatic Fistula
Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy
Patients who are diagnosed with periampullary cancer will be performed pancreaticoduodenectomy with 3 types of pancreatic-jejunal anastomosis reconstructions.
- Trial name
- NCT05017207
- Testing
- Pancreaticoduodenectomy
- Where
- Vietnam
- Volunteers
- 183 people
- Sponsor
- Vo Truong Quoc
Periampullary Cancer, Complications of Surgical Procedures or Medical Care
Comparison Between Fully Covered Metal Stents and Plastic Stents in Preoperative Biliary Drainage
This study is a prospective, randomized study to compare of outcome of fully covered metal stents with that of plastic stents for preoperative biliary drainage in distal common bile duct cancer, pancreas head cancer or ampullary…
- Conditions
- Periampullary Cancer, Complications of Surgical Procedures or Medical Care, Disorder of Bile Duct Stent
- Trial name
- NCT01789502
- Testing
- Fully covered metal stents, Plastic stents
- Where
- 3 sites in South Korea
- Volunteers
- 86 people
- Sponsor
- Inje University
Pancreatic Adenocarcinoma, Pancreatic Cysts
Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors
This multicenter randomized trial aims to primarily assess and compare the functional recovery of patients who undergo open versus robotic pancreaticoduodenectomy for benign and malignant lesions of the head of the pancreas.
- Conditions
- Pancreatic Adenocarcinoma, Pancreatic Cysts, Pancreatic Endocrine Tumors, Chronic Pancreatitis
- Trial name
- PORTAL (NCT04400357)
- Testing
- Robotic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Ruijin Hospital
Periampullary Cancer, Borderline Malignancy Tumor
The Effect of ERAS on Pancreaticoduodenectomy (v2.0)
Enhanced Recovery After Surgery (ERAS) is not a program that aims to reduce postoperative hospital stay, but the multimodal strategies that aim to attenuate the loss of, and improve the restoration of, functional capacity after…
- Trial name
- NCT06009224
- Testing
- ERAS perioperative management
- Where
- South Korea
- Volunteers
- 334 people
- Sponsor
- Asan Medical Center
Periampullary Cancer, Pancreatic Fistula
Complication of Pancreatic Fistula and Bleeding After Pancreaticoduodenectomy in Treatment Periampullary Cancer
This multi-site study will be done across Hepatobiliary and Pancreatic Surgery Department at Cho Ray Hospital and University and Pharmacy Center.
- Conditions
- Periampullary Cancer, Pancreatic Fistula, Bleeding
- Trial name
- PF (NCT04985071)
- Testing
- Pancreaticoduodenectomy
- Where
- Vietnam
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Vo Truong Quoc
Periampullary Cancer
Clinical Impact of Altitude Level on Surgical Outcomes of Pancreaticoduodenectomy
Very few papers examine the effect of living at high altitudes on surgical results of major operations. This research is designed to determine the surgical outcomes of PD for periampullary tumour in high altitudes and normal…
- Trial name
- PD (NCT04401722)
- Testing
- PANCREATICODUDENECTOMY
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
Pancreas Cancer, Periampullary Cancer
Reconstruction Following Pancreaticoduodenectomy: A Randomized Clinical Trial of Pancreaticojejunostomy vs Pancreaticogastomy
Pancreaticoduodenectomy (PD or Whipple procedure) involves the removal of the head of the pancreas and is the primary modality for treatment of peri-ampullary cancers (arising from the common bile duct, Ampulla of Vater…
- Trial name
- NCT00841607
- Testing
- pancreaticojejunostomy vs pancreaticogastrostomy
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- Tom Baker Cancer Centre
Periampullary Carcinoma
Total Laparoscopic vs Open Pancreaticoduodenectomy for the Treatment of Periampullary Adenocarcinomas
Laparoscopic pancreaticoduodenectomy (LPD), a surgical option for nonpancreatic periampullary adenocarcinoma (NPPA), is a complex procedure that has become increasing popular.
- Trial name
- NCT07388082
- Testing
- Conventional open pancreaticoduedectomy, Total laparoscopic pancreaticoduedectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Theodor Bilharz Research Institute
Pancreatic Cancer
Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer
Determine if the addition of an intraoperative ethanol celiac plexus neurolysis (alcohol block) in patients undergoing surgical intervention for pancreatic cancer will result in a decrease in cancer associated pain
- Trial name
- NCT00806611
- Testing
- Alcohol Block
- Where
- United States
- Volunteers
- 438 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Cancer Gi
Prophylactic EUS-guided Gastroenterostomy in Advanced Periampullary Cancers
The goal of this randomized controlled trial is to investigate the effectiveness and safety of Prophylactic EUS-gastroenterostomy (ProEUS-GE) as a preventative approach for malignant gastric outlet obstruction (MGOO) in men and…
- Trial name
- INTERCEPT (NCT05994521)
- Testing
- ERCP alone, ERCP +ProEUS-GE
- Where
- 5 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
This randomized controlled trial investigates the safety and efficacy of injecting N-butyl-2- cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07230509)
- Testing
- Pancreatic parenchymal injection of N-butyl-2- cyanoacrylate(Histoacryl®)Injection Group., Standard Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Periampullary Cancer, Postoperative Pancreatic Fistula
Pancreatic Head Resection or Total Pancreatectomy With Islet Autotransplantation in Patients With Periampullary Cancer and High Risk Profile for the Development of Postoperative Pancreatic Fistula
The primary objective of this clinical trial is to evaluate whether primary total pancreatectomy with simultaneous islet autotransplantation compared with pancreatic head resection (alone) can reduce perioperative morbidity and…
- Trial name
- XandTX (NCT05843877)
- Testing
- Intraportal transplantation of isolated autologous pancreatic islets after total pancreatectomy, Pancreaticoduodenectomy (classic Whipple or pylorus-preserving)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Technische Universität Dresden
Stage, Pancreatic Cancer, Neoplasm, Residual
Multicolour Versus Monocolour Specimens Inking After Pancreaticoduodenectomy for Periampullary Cancer
A single-centre, randomised clinical trial of patients affected by periampullary cancer who underwent pancreaticoduodenectomies which included two different types of specimen margination: arm A (multicolour inking) and arm B…
- Conditions
- Stage, Pancreatic Cancer, Neoplasm, Residual, Pancreatic Neoplasm, Periampullary Cancer
- Trial name
- MPM (NCT02900950)
- Testing
- Multicolour inking specimens, Monocolour inking specimens
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Biliary Tract Cancer, Periampullary Adenocarcinoma
SOX Sequential S-1 in Advanced Biliary Tract Carcinoma（BTC）and Pancreatic Cancer
This is an exploratory, single-armed, open label study on the efficacy and safety of sequential S-1 therapy after SOX in unresectable metastatic or locally advanced biliary system or periampullary cancer or pancreatic cancer…
- Conditions
- Biliary Tract Cancer, Periampullary Adenocarcinoma, Pancreatic Cancer
- Trial name
- NCT01811277
- Testing
- SOX sequential S-1
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University