Clinical trials: Perinatal
Preeclampsia, Intrauterine Growth Restriction
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
Preeclampsia (PE) affects ~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world.
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Maternal Hypertension, Neonatal Outcome
- Trial name
- PE37 (NCT04766866)
- Testing
- sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
- Where
- 21 sites in Belgium, Colombia and 7 more
- Volunteers
- 9,132 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Grief, Depressive Symptoms
Impact of a Neonatal-Bereavement-Support DVD on Grief
Experts agree that neonatal death has long-term impact on parents. Many parents experience sadness, pain, anger, bouts of crying, and a depressed mood after the death of a child.
- Trial name
- NCT01926080
- Testing
- DVD Intervention Arm
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Maternal Care
Holistic Care Partner Program Feasibility and Acceptability
The study aims to build on the knowledge of the United States' ongoing maternal health crisis for Black birthing people. The study team will take a holistic focused approach to build on the experiences of Black women perinatal…
- Trial name
- NCT06520566
- Testing
- Holistic care partner perinatal nurse navigation
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pregnancy, Cannabis
Development of a Lifestyle Physical Activity Intervention to Reduce Risk for Perinatal Cannabis Use
This study will recruit 20 women who are high risk for prenatal cannabis use for a 12-week program of using the tracker and receiving a Lifestyle Physical Activity program.
- Trial name
- NCT05528380
- Testing
- LPA + Fitbit Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Vaccination
P3+ Intervention Phase
This study will address vaccine uptake both for pregnant women and for their children, through 20 months of age, to test the hypothesis that exposure to the P3+ intervention package will increase the likelihood a pregnant woman…
- Trial name
- NCT02898688
- Testing
- Control Site, Intervention Site, Patient-level Control Group
- Where
- 23 sites in United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Emory University
Advanced Maternal Age Pregnancy, High Risk Pregnancy
University Hospital Advanced Age Pregnant Cohort
The University Hospital Advanced Age Pregnant (UNIHOPE) Cohort is the major part of the National Key Research and Development Program on Reproductive Health \& Major Birth Defects Control and Prevention Project, which is funded…
- Conditions
- Advanced Maternal Age Pregnancy, High Risk Pregnancy, Perinatal Death, Maternal Death
- Trial name
- UNIHOPE (NCT03220750)
- Where
- 9 sites in China
- Volunteers
- 22,000 people, healthy volunteers welcome
- Sponsor
- Peking University
Asthma, Dermatitis, Atopic
Impact in Off-spring of Mothers After Perinatal Daily Intake of a Probiotic
A probiotic (Lactobacillus rhamnosus GG) supplement to pregnant women the last four weeks of pregnancy and three months after birth is expected to give a 40% reduction in risk of atopic sensitisation and allergic disease at two…
- Conditions
- Asthma, Dermatitis, Atopic, Rhinitis, Allergic, Perennial
- Trial name
- NCT00159523
- Testing
- Probiotic
- Where
- Norway
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Attachment Disorder
Investigation of the Effect of Attachment-Based Support Given in the Perinatal Period
It is important that effective intervention programs are developed and implemented in our country by identifying risk factors in the early period. In this aspect, the work is unique.
- Trial name
- NCT05676996
- Testing
- attachment-based support
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Pregnancy Related
Well-Mama Community Doula Navigator Study
This study will develop and test an intervention, called the Well-Mama intervention, which includes the use of a checklist by Community Doula Navigators to support pregnant women.
- Trial name
- NCT05179369
- Testing
- Standard Care with Well-Mama Intervention
- Where
- 2 sites in United States
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Perinatal Hypoxia, Dopamine
Measuring Brain Activity of School Age Children
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
- Conditions
- Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
- Trial name
- NCT03407729
- Testing
- Magnetic Resonance Imaging, Cognitive Performance Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Antenatal Care and Delivery
Increasing Women's Access to Skilled Pregnancy Care to Reduce Maternal Mortality in Nigeria
Background: Nigeria has the second highest absolute number of maternal deaths and perinatal deaths in the world. The country contributes 14% of all maternal deaths worldwide, second only to India.
- Trial name
- NCT02643953
- Testing
- Incentives, Community
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Depression, Pregnancy
A Prenatal Bonding Intervention for Pregnant Women With Depression
The goal of this clinical trial is to test a group for pregnant women with depression that aims to help them build a stronger relationship with their unborn baby.
- Trial name
- NCT05628675
- Testing
- Baby CHAT
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- King's College London
Anxiety Disorder (Panic Disorder or GAD), Anxiety Symptoms
Anxiety is One of the Most Frequent Disorders During the Perinatal Stage Which is Associated with Adverse Health Effects for Women and Their Babies. This Study Will Be to Evaluate the Effectiveness of a Telematic Cognitive-behavioral Preventive Intervention to Manage Anxiety During Pregnancy.
Anxiety is one of the most frequent disorders during the perinatal stage which is associated with adverse health effects for women and their babies. In spite of this, preventive interventions during this stage are scarce.
- Trial name
- NCT06609291
- Testing
- Telematic Prenatal Psychological Intervention for Preventing Anxious Symptomatology
- Where
- Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Perinatal Depression
Center M: Digital Health Innovation Pilot
Center M is a digital health solution to Perinatal Depression (PD) which provides an alternative to Mindfulness Based Cognitive Therapy - Perinatal Depression (MBCT-PD).
- Trial name
- NCT06000449
- Testing
- Center M, Treatment as Usual
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pregnancy
SmartMom: Teaching by Texting to Promote Health Behaviours in Pregnancy
The goal of this randomized clinical trial is to evaluate the effectiveness of SmartMom, a text messaging-based mobile health program for prenatal education.
- Trial name
- NCT05793944
- Testing
- SmartMom text messaging, Control text messaging
- Where
- Canada
- Volunteers
- 3,078 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Fetal Distress, Perinatal Asphyxia
Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
The PRISM pilot feasibility study consists of two phases to determine: 1) to delivery practices, rates of primary and secondary outcomes, and feasibility of enrollment rates, and 2) to assess the feasibility and acceptability of…
- Conditions
- Fetal Distress, Perinatal Asphyxia, Birth Asphyxia, Stillbirth
- Trial name
- PRISM (NCT05946681)
- Where
- Zambia
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Pregnancy Related, Adolescent Obesity
#BabyLetsMove Physical Activity Feasibility Trial
Black adolescents who are pregnant represent a high-risk and understudied perinatal population in health research. Adolescent pregnancy (<20 years) is disproportionately prevalent among Blacks compared with Whites and is a…
- Conditions
- Pregnancy Related, Adolescent Obesity, Behavior, Health, Behavior, Sedentary
- Trial name
- NCT04628065
- Testing
- #BabyLetsMove
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Psychological Well-being, Childbirth
Supportive Care During Childbirth and Well-being
The aim of this study is to evaluate the effects of continuous supportive care (ICSC) at birth on some parameters of maternal psychological well-being.
- Conditions
- Psychological Well-being, Childbirth, Care Pattern, Maternal
- Trial name
- NCT05333653
- Testing
- Continouse supportive care, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Mersin University
Pregnancy, Prenatal Care
Perinatal mHealth Intervention in Guatemala
The purpose of the study is to explore ways to improve maternal and child outcomes in the ethnic Maya speaking the Kaqchikel language population, which experiences wide disparities in health care access and outcomes when compared…
- Trial name
- NCT02348840
- Testing
- mHealth
- Where
- Guatemala
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Emory University
Child Development, Mental Health
Impact of a Medical-Financial Partnership Intervention on Parent Mental Health, Perinatal Outcomes, and Child Developmental Risk
Poverty and financial stress are key social drivers of health and root causes of worse health beginning in pregnancy, continuing into childhood, and extending over the life course, but clinical tools to address the health impacts…
- Trial name
- NCT07064915
- Testing
- Medical-Financial Partnership Support
- Where
- 4 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles