Clinical trials: Perineal Wound Healing
Perineal Tear and Episiotomy
The Effect of Mucogyne® Gel on Wound Healing
The aim of this post-market clinical follow up study is to confirm the efficacy and safety of topical application of Mucogyne® gel in the process of wound healing, when used in accordance with its approved labeling, in the…
- Trial name
- ARTHEMIS (NCT05888194)
- Testing
- Mucogyne® gel
- Where
- 3 sites in France
- Volunteers
- 118 people
- Sponsor
- Biocodex
Skin Structures and Soft Tissue Infections, Wound Infection
The PLUS Study: Comparison of VicrylPlus® Versus Vicryl® for Repair of Perineal Tears
INTRODUCTION It is estimated that over 80% of women who give vaginal birth will sustain some form of perineal tear and of these 60-70% will require suturing.
- Trial name
- NCT02863874
- Testing
- VicrylPlus®, Vicryl®
- Where
- Sweden
- Volunteers
- 1,890 people
- Sponsor
- Region Skane
Pain
Nonpharmacological Method for Relief During Episiotomy Repair
The study was planned as a randomized controlled trial to evaluate the effect of reflexology on perceived perineal pain during episiotomy repair.
- Trial name
- NCT06484309
- Testing
- Reflexology Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Dehiscence Wound, Secondary Perineal Tear
Conservative Treatment or Resuturing Among Women With Perineal Wound Dehiscence After Vaginal Labour
The goal of this observational study is to make us more aware of the short and long-term outcomes for women having an uncomplicated healing process after a rupture or birth cut in the perineum after giving birth in relation to a…
- Conditions
- Dehiscence Wound, Secondary Perineal Tear, Episiotomy; Dehiscence
- Trial name
- HEAL (NCT06026423)
- Testing
- Clinical examination and pictures, Questionnaire
- Where
- Denmark
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Vaginal Laceration During Delivery
Antibiotics for Severe Perineal Laceration to Prevent Infection Following Repair
Many women experience severe anal sphincter lacerations during childbirth, which put them at risk for infection, improper healing, and accidental bowel leakage.
- Trial name
- ASPIRe (NCT04573504)
- Testing
- Augmentin/Flagyl or Augmentin/Clindamycin
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Northwestern University
Perineal Lacerations, Delivery, Obstetric
Photobiomodulation for Episiotomies and Perineal Lacerations After Vaginal Delivery.
Episiotomies (EP) and perineal lacerations (PL) following vaginal delivery can lead to complications such as pain, edema, and infection.
- Conditions
- Perineal Lacerations, Delivery, Obstetric, Episiotomy Wound, Photobiomodulation Therapy
- Trial name
- NCT06893315
- Testing
- Photobiomodulation Therapy, Hospital Standard Protocol of treatment for pain and healing
- Where
- Brazil
- Volunteers
- 183 people
- Sponsor
- University of Nove de Julho
Improving Quality of Life
Pain Relief During Repair of Postpartum Perineal Tears
The aim of our study is to compare the analgesic effect of topical application of lidocaine-prilocaine cream and lidocaine infiltration during repair of postpartum perineal tears.
- Trial name
- LPPT (NCT02883179)
- Testing
- lidocaine injection, lidocaine-prilocaine cream
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Assiut University
Perineal Trauma, Postpartum Pain
RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy
Perineal tears and episiotomies are common after vaginal birth and may cause persistent pain, impaired wound healing, pain during sexual activity, and concerns about genital appearance.
- Conditions
- Perineal Trauma, Postpartum Pain, Episiotomy, Perineal Laceration
- Trial name
- RELIEVE (NCT07727213)
- Testing
- Autologous Non-Activated Platelet-Rich Plasma, Saline (0.9%, sterile, for infusion)
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Vaginal Laceration During Delivery
The PAIN (Pelvic Area Injection for Numbness) Study
Postpartum pain can interfere with patient's ability to care for themselves, and their newborn, and untreated pain is associated with risk of greater opioid use, postpartum depression, and development of persistent pain.
- Trial name
- PAIN (NCT05972681)
- Testing
- Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Episiotomy
Different Techniques for Perineal Skin Closure During Mediolateral Episiotomy Repair
this study aims to assess the efficacy and the safety of various cosmetic techniques (subcuticular, surgical glue, adhesive tapes) for perineal skin closure during mediolateral episiotomy repair
- Trial name
- NCT03780530
- Testing
- subcuticular suturing, Surgical glue, adhesive steri-strip tape
- Volunteers
- 207 people
- Sponsor
- Ain Shams University
Perineal Pain
Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia
This trial will be performed to compare the effectiveness of oral tramadol versus oral celecoxib for the management of perineal pain following episiotomy or perineal tear repair after spontaneous vaginal birth in obese women
- Trial name
- NCT03694873
- Testing
- Tramadol Hydrochloride, Celecoxib 200mg
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Perineal Trauma, Episiotomy
Effect of Boric Acid Wet Dressing on Postpartum Perineal Healing and Pain
Perineal trauma, including episiotomy and first- or second-degree perineal tears, is a common postpartum condition associated with pain and delayed wound healing after vaginal birth.
- Conditions
- Perineal Trauma, Episiotomy, Episiotomy Wound, Perineal Pain
- Trial name
- NCT07748182
- Testing
- 2% Boric Acid Wet Dressing, 0.9% Normal Saline Wet Dressing, Routine Care Group
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Saglik Bilimleri Universitesi
Perineum; Injury, Episiotomy Wound
Use Of Virtual Reality To Reduce Anxiety And Pain During Repair Of Perineal Laceration And Episiotomy
Virtual Reality will be used to decrease anxiety and pain during suturing of episiotomy and perineal lacerations
- Conditions
- Perineum; Injury, Episiotomy Wound, Anxiety
- Trial name
- NCT04693013
- Testing
- Virtual Reality for Anxiety Reduction
- Where
- Israel
- Volunteers
- 84 people
- Sponsor
- Ziv Hospital
Neuralgia, Perineal
Promoting Optimal Healing After Laceration Repair Study
The goal of this research is to investigate three different methods of perineal skin closure during second-degree perineal wound repair and determine which method is associated with the least amount of patient pain.
- Trial name
- PALS (NCT02055794)
- Testing
- Suturing of the perineal skin, Closing perineal skin with surgical glue, No suturing of the perineal skin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Fourth Degree Perineal Laceration Involving Anal Mucosa, Obstetric; Injury
Use of the Modified Beef Tongue Model for Teaching Repair of Obstetrical Fourth-Degree Laceration to Residents
This is a study evaluating the use of the modified beef tongue model for teaching repair of obstetrical fourth-degree laceration to residents.
- Conditions
- Fourth Degree Perineal Laceration Involving Anal Mucosa, Obstetric; Injury, Obstetric Labor Complications
- Trial name
- NCT03341351
- Testing
- Instructional video, Instructional workshop
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Postpartum Perineal Pain
AI-Supported Video Education in Episiotomy Care
Although the postpartum period is generally considered a positive experience, obstetric interventions such as episiotomy may lead to significant maternal health problems.
- Trial name
- NCT07453979
- Testing
- Control, AI-Assisted Episiotomy Care Video Group
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Burdur Mehmet Akif Ersoy University
Vaginal Discharge, Perineum; Rupture
Efficacy and Safety of the Application of Local Anaesthetic in Spray to Repair of 1st- 2nd Perineal Lacerations
Randomized controlled trial aimed at evaluating the efficacy and safety of the use of a local anesthetic spray, commonly used in clinical practice as off-label, during the suturing of perineal lacerations in post-partum…
- Conditions
- Vaginal Discharge, Perineum; Rupture, Analgesia
- Trial name
- LISPRAY (NCT05201313)
- Testing
- Lidocaine Hydrochloride, Mepivacaine Injection
- Where
- Italy
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Perineal Injury
The Use of St. John's Wort Oil With Massage in the Perineum During Childbirth
Perineal trauma, whether spontaneous or episiotomy, is a condition that affects the quality of life in primiparous women . In women who have experienced perineal trauma, problems such as dyspareunia, urinary and fecal…
- Trial name
- NCT05164926
- Testing
- perineal massage with St. John's Wort oil
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Episiotomy , Perineal Pain
Pudendal Nerve Block for Pain Relief During Episiotomy Repair: A Randomized Controlled Trial
Episiotomy is a surgical cut made in the perineum, the area between the vagina and anus, during vaginal childbirth. Repairing an episiotomy can cause pain, and adequate pain relief is important for maternal comfort during and…
- Trial name
- NCT07883473
- Testing
- Pudendal Nerve Block, Conventional Local Perineal Infiltration
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Birth Injuries, Lacerations
Acupuncture for Pain Relief During Perineal Repair After Childbirth
Midwives and obstetricians are currently using acupuncture for several health problems during pregnancy and childbirth. The investigators wish to determine whether acupuncture can be used as pain relief during the repair of…
- Conditions
- Birth Injuries, Lacerations, Pain
- Trial name
- NCT00328796
- Testing
- acupuncture in 6 specific points, lidocaine 10mg/ml
- Where
- Denmark
- Volunteers
- 207 people
- Sponsor
- Sonderborg Hospital