Clinical trials: Periodontal Defect
Periodontal Diseases
Minimally Invasive Surgical Technique in Management of Intrabony Defects
In the fast-growing era of contemporary periodontology, the understanding of biological concepts in wound healing together with the evolution of the flap design and biomaterials applied in periodontal regeneration allowed for…
- Trial name
- NCT06591416
- Testing
- minimally invasive surgical technique, minimally invasive surgical technique with granulation tissue preservation
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Intrabony Periodontal Defect
Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a GTR procedure, when it is combined with an immediate orthodontic tooth movement or used alone.
- Trial name
- NCT04896450
- Testing
- Guided tissue regeneration (GTR), Orthodontic tooth movement (OTM)
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Treatment of Periodontal Intra-bony Defects
The Present Study Was Performed to Evaluate the Efficacy of Lyophilized-PRF in Treatment of Periodontal Intra-bony Defects
The present study will be performed to evaluate the efficacy of lyophilized platelet-rich fibrin alone and combined with nanocrystalline hydroxyapatite in treatment of periodontal intra-bony defects through: 1.
- Trial name
- NCT06625528
- Testing
- open flap debridement
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Intrabony Periodontal Defect
Rh-PDGF vs EMD for Treatment of Intra-bony Defects
Treatment of intra-bony defects is challenging and requires extensive knowledge of the etiology, anatomy, occlusion, and available biomaterials that can be used to treat this kind of defects.
- Trial name
- NCT05442034
- Testing
- growth factors to help in regeneration
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Intrabony Periodontal Defect
Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects.
The aim of the present study was to evaluate the bone formation potential of 400µg alendronate delivered in β-TCP in the treatment of periodontal intra-osseous defects.
- Trial name
- NCT02795546
- Testing
- Alendronate sodium, beta-tricalcium phosphate bone substitute
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Intrabony Periodontal Defect
Clinical and Radiographic Evaluation of the Entire Papilla Preservation (EPP) Technique Versus Modified Minimally Invasive Surgical Technique (M-MIST) in Treatment of Intraosseous Defects in Patients With Stage III Periodontitis: A Randomized Clinical Trial
Periodontitis is defined as loss of periodontal attachment due to microbial associated host mediated inflammation. This would lead to the apical migration of the junctional epithelium allowing the bacterial biofilm to undergo…
- Trial name
- NCT04100798
- Testing
- Entire Papilla Preservation technique, Modified Minimally invasive Surgical Technique
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Tooth Migration
Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration
Pathologic tooth migration (PTM) is a common complication of advanced periodontitis and often motivation for patients to seek orthodontic therapy.
- Conditions
- Periodontitis, Tooth Migration, Intrabony Periodontal Defect
- Trial name
- NCT02761668
- Testing
- ParS+Ortho 4W, ParS+Ortho 6M
- Where
- 2 sites in Germany, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Intrabony Periodontal Defects
Minimally Invasive Non Surgical Treatment Using Injectable Platelet Concentrate in Treatment of Deep Pockets.
The purpose of this study is to evaluate change in pocket depth following using minimally invasive non surgical combined with injectable platelet concentrate .
- Trial name
- NCT07722390
- Testing
- Injectable PRF, MINST
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Regenerative Combined Therapy With Enamel Matrix Derivative and Biphasic Calcium Phosphate Graft
Background: The use of Enamel Matrix Derivative (EMD) when dealing with non-contained defects may be limited, as EMD does not maintain a space itself.
- Trial name
- NCT02828423
- Testing
- EMD, BC
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Periodontal Diseases, Intrabony Periodontal Defect
Papilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Treating Isolated Bone Defects Between Teeth
The present three-arm study compared the clinical and tomographic efficacy of the Entire Papilla Preservation Surgical Technique (EPPT) alone and combined with enamel matrix derivative (EMD) plus bone mineral derivedxenograph…
- Trial name
- NCT07119307
- Testing
- Entire Papilla Preservation Technique, Entire Papilla Preservation Surgical Technique (EPPT) alone, Entire Papilla Preservation Surgical Technique (EPPT) alone and combined with enamel matrix derivative (EMD)
- Where
- India
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rungta College of Dental Sciences and Research
Prosthetic Tissue Defect, Dental Prosthesis Complication
Study of Periodontal Tissues in Fixed Prostheses on Natural Teeth
When the tooth is severely compromised, it needs a prosthetic crown. The tooth is prepared to allow the housing of the prosthetic crown without difficulty.
- Conditions
- Prosthetic Tissue Defect, Dental Prosthesis Complication, Dental Prosthesis Failure, Tissue Injury
- Trial name
- NCT04151316
- Testing
- crown preparation, vertical preparation, horizontal preparation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Intrabony Periodontal Defect
Periodontal Regeneration Using Vitamin A and PRF Compared to PRF Alone Treating Intra-bony Defects
Will the addition of vitamin A (Retinol) to PRF add more periodontal regenerative value in the treatment of intra-bony defects compared to PRF alone, clinically?
- Trial name
- NCT05285293
- Testing
- Platelet Rich Fibrin (PRF), Platelet Rich Fibrin (PRF) and Retinol
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects
The ultimate goal of periodontal therapy is the regeneration of periodontal tissues which have been destroyed due to periodontal disease.
- Trial name
- NCT03399279
- Testing
- Open flap debridment, Perforated collagen membrane, Occlusive membrane
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Evaluation of Autogenous Demineralized Dentin Graft Vs Autogenous Bone Graft in Management of Intrabony Defects
The main goal is to evaluate and compare the clinical and radiographic efficacy of autogenous demineralized dentin as bone graft substitute versus autogenous bone graft when performed with modified minimally invasive surgical…
- Trial name
- NCT06048042
- Testing
- Autogenous Demineralized Dentin Graft, Autogenous Bone Graft
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bone Loss, Alveolar
Evaluation of Bone Gain Using Customized 3D Zirconia Barrier Versus Titanium Mesh
Evaluation of clinical and radiographical amount of bone gained using customized 3D printed zirconia barrier compared to titanium mesh in combined ridge defect at the esthetic zone.
- Trial name
- NCT06559605
- Testing
- zirconia barrier, titanium mesh
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
RT2 Gingival Recession
Comparing Deepithelialized Free Gingival Graft Versus Subpithelial Connective Tissue Graft With Tunneling Technique in Treating RT2 Gingival Recession
Complete coverage of the recession complemented with pleasing esthetics and minimal probing measures are the main goals of root coverage procedures.
- Trial name
- NCT04104087
- Testing
- tunneling technique with sub epithelial connective tissue graft or deepithelialized free gingival graft.
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Peri-implantitis
Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony Defects
To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
- Trial name
- Bony defects (NCT07809334)
- Testing
- Reconstructive therapy
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Periodontitis, Intrabony Periodontal Defect
MIST Versus M-MIST for the Treatment of Intrabony Defects
This is a 12-month longitudinal, double-blind, parallel-design randomized controlled clinical trial involving surgical therapeutic intervention (Phase 4).
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontitis, Chronic
- Trial name
- NCT06058923
- Testing
- M-MIST, MIST
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontitis
Clinical and Biochemical Assessment of Ozonated Olive Oil Mixed Bone Substitute in Treating Intra Bony Periodontal Defect
The goal of this study is to investigate the effect of ozonated olive oil in treating intra bony defect by means of clinical and radiographic parameters, and gingival cervicular fluid BMP2 level.
- Trial name
- NCT05655923
- Testing
- ozonized olive oil, xenograft bone substitute
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Efficacy of Titanium Granules in the Treatment of Periodontal Intrabony Defects
The ideal goal of the periodontal treatment is not only to prevent the progression of the disease, but also the regeneration and reconstruction of lost tissues.
- Trial name
- NCT04932161
- Testing
- Titanium Granules, Hydroxyapatite
- Where
- India
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences