Clinical trials: Periodontal Defect
Intrabony Periodontal Defect
Evaluation of Volume Stable Collagen Matrix in the Regenerative Outcome of Periodontal Intrabony Defects
Periodontal intrabony defect is a specific osseous defect with definite morphology. Numerous therapeutic modalities for restoring such defects have been investigated.
- Trial name
- NCT05569473
- Testing
- TEST GROUP: VCMX + OFD, CONTROL GROUP : OFD ONLY
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Intrabony Defect
Regenerative Potential of Cultured Gingival Fibroblast- Mesenchymal Stem Cells in Treatment of Periodontitis
clinical trial was conducted to evaluate regenerative potentials of cultured gingival fibroblasts and GMSCs carried in beta tri calcium phosphate scaffold into intrabony periodontal defects in human by clinical and radiographic…
- Trial name
- NCT03638154
- Testing
- GF+GMSCs carried on β TCP, β TCP bone substitute only
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Regeneration of Intrabony Defects With Nano Hydroxyapatite Graft, and Periosteum as Barrier Membrane Under Magnification
The prospective study is a interventional study to evaluate and compare the effectiveness of periosteal pedicle as grafting technique and egg shell derived nano hydroxyapatite as regenerative graft material for regeneration of…
- Trial name
- NCT04195295
- Testing
- Regeneration of Intrabony Defects with Nano Hydroxyapatite Graft, Derived from Egg Shell along with Periosteum as Barrier Membrane, Regeneration of intrabony defects using Egg shell derived nano hydroxyapatite (EnHA) as regenerative graft material, Open flap debridement procedure in intrabony defects.
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Attachment Loss
Non - Incised Papilla Versus Single Flap Technique In The Reconstruction Of Intrabony Defect
The present study will aim to assess the effectiveness of the non-Incised Papilla surgical approach NIPSA used for the surgical debridement of deep intraosseous defects compared to the single-flap approach SFA.
- Trial name
- NCT06003322
- Testing
- non - Incised Papilla surgical approach NIPSA for intrabony defect, single-flap approach SFA
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Advanced Platelet Rich Fibrin in Periodontal Angular Defects
The aim of this study is to clinically and radiographically evaluate the efficacy of advanced platelet-rich fibrin (A-PRF) when used with biphasic alloplast in the management of intrabony defects in patients with moderate to…
- Trial name
- NCT03433066
- Testing
- Advanced platelet-rich fibrin mixed with biphasic alloplast, Biphasic alloplast mixed with saline
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Alveolar Bone Loss Associated Chronic Periodontitis
Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis
This open label, randomized controlled clinical trial study will be conducted after obtaining ERC approval of Bahria University Health Sciences. Written informed consent will be taken from all study participants.
- Trial name
- NCT06856369
- Testing
- Platelet rich fibrin, Metformin hydrochloride powder, alendronate sodium powder
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bahria University
Periodontal Diseases
Periodontal Regeneration Using Dental Pulp Stem Cells (DPSCs)
The goal of this study is to evaluate if dental pulp stem cells (DPSCs) delivered into intrabony defects in a collagen scaffold would enhance the clinical and radiographic parameters of periodontal regeneration.
- Trial name
- NCT03386877
- Testing
- periodontal regeneration
- Where
- 2 sites in Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Periodontitis, Bone Loss
Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis…
- Conditions
- Chronic Periodontitis, Bone Loss, Intrabony Periodontal Defect
- Trial name
- NCT04767243
- Testing
- open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin), open flap debridement and filled with Bioactive glass (Perioglas®), open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Periodontal Bone Loss, Periodontal Pocket
Treatment of Intraosseous Periodontal Defects With Hyaluronic Acid
The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of a hyaluronic acid-based gel, compared to MINSD…
- Trial name
- NCT05188898
- Testing
- MINSD and Hyaluronic acid, MINSD
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Intrabony Periodontal Defect
Allograft With Enamel Matrix Derivative Versus Allograft Alone in the Treatment of Intrabony Defects .
Periodontal intrabony defects represent a major challenge for the clinician in periodontal therapy. If left untreated, these defects represent a risk factor for disease progression and additional attachment and bone loss.
- Trial name
- NCT06041854
- Testing
- Freeze-dried bone allograft combined with Enamel Matrix derivative, Freeze-dried bone allograft
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Peri-Implantitis and Peri-implant Mucositis
Risk Assessment of Proximal Contact Loss Between Implant-supported Prostheses and Adjacent Teeth.
In this study, we collected and analysed the review results of 100 patients over 18 years of age who received implant fixed restorations in the Department of Stomatology of the First Hospital of Nanjing, China.
- Trial name
- NCT06475313
- Testing
- plaque index assessment, periodontal probing, Bleeding on probing (BOP), Prosthetic adjacency check, initial occlusal contact, maximum occlusal contact, and filling of the cusps.
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Prosthetic Tissue Defect, Dental Prosthesis Complication
Study of Periodontal Tissues in Fixed Prostheses on Natural Teeth
When the tooth is severely compromised, it needs a prosthetic crown. The tooth is prepared to allow the housing of the prosthetic crown without difficulty.
- Conditions
- Prosthetic Tissue Defect, Dental Prosthesis Complication, Dental Prosthesis Failure, Tissue Injury
- Trial name
- NCT04151316
- Testing
- crown preparation, vertical preparation, horizontal preparation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Peri-implantitis
Reconstructive Treatment of Peri-implantitis With Combined Defects
The aim of this randomized clinical study is to assess the additional clinical benefit of incorporating a resorbable collagen membrane (CM) alongside a xenogeneic bone graft-specifically, deproteinized bovine bone mineral with…
- Trial name
- NCT06957652
- Testing
- DBMM-C plus Resorbable collagen membrane, DBMM-C
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Alveolar Ridge Deficiency, Alveolar Bone Loss
Novel Synthetic Membrane for Horizontal Bone Augmentation: A Case Series
The goal of this clinical study is to learn if the Inox Nanoksa G-Plus membrane works to rebuild bone in the upper or lower jaw (ridge augmentation) for adults who need dental implants but do not have enough bone width or height.
- Trial name
- NCT07701473
- Testing
- Inox Nanoksa G-Plus Membrane, Particulate Bone Graft
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Defect
Effect of Autogenous Demineralized Dentin as a Bone Graft Substitute in Management of Periodontal Intrabony Defects
one of the ultimate goals in periodontology is to achieve periodontal regeneration and change the prognosis of questionable or hopeless teeth to maintainable.Bone substitutes have been actively used to reconstruct bony defects.
- Trial name
- NCT05445102
- Testing
- autogenous demineralized dentin graft as bone substitute in treatment of intrabony defect
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Peri-implantitis
Surgical Protocol for Peri-implantitis Treatment
Peri-implant diseases are common post-restorative complications in implant rehabilitations and they occur with an incidence of 12-43%.
- Trial name
- NCT03801187
- Testing
- chlorhexidine, Er:YAG laser, Air-Powder
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Periodontitis, Periodontal Diseases
Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
This study is meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with papilla preservation flap versus papilla…
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Pocket, Intrabony Periodontal Defect
- Trial name
- NCT03588507
- Testing
- PPF+NCHA bone graft substitute
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a GTR procedure, when it is combined with an immediate orthodontic tooth movement or used alone.
- Trial name
- NCT04896450
- Testing
- Guided tissue regeneration (GTR), Orthodontic tooth movement (OTM)
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University