Clinical trials: Periodontal Disease Stage 2
Periodontal Disease Stage 2
Interleukin-34 Level in Periodontal Disease
Aim of the study: 1. To investigate changes in the levels of Interleukin 34 (IL-34) in the Gingival crevicular fluid(GCF) of patients with stage II periodontitis patients before and after nonsurgical periodontal therapy and…
- Trial name
- NCT05962567
- Testing
- Non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis
Effect of Menstrual Cycle Phase on Pain Perception and Anxiety During Non-Surgical Periodontal Treatment
This study evaluates the effect of menstrual cycle phases on pain perception and dental anxiety during non-surgical periodontal therapy in premenopausal women with Stage II and III periodontitis.
- Trial name
- MAPP (NCT07719686)
- Testing
- Non Surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Karadeniz Technical University
Periodontitis Stage II, Gingival Pocket
Use of Injectable Extended Platelet-Rich Fibrin as a Local Drug Delivery in the Treatment of Stage II Periodontitis Patients
The objective of the present study is to assess the clinical effectiveness of local delivery of injectable extended platelet-rich fibrin in subgingival application when used in conjunction with scaling and root planing (SRP) in…
- Trial name
- NCT07080294
- Testing
- extended platelet rich fibrin injection in pocket, albumin injection in pocket, scaling and root planing
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Periodontitis Stage II, Periodontitis Stage III
3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV
What is the purpose of this study? This study is to investigate the effect of a processed blood product in healing after treatment for gum disease.
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), Periodontitis
- Trial name
- NCT07293962
- Testing
- Normal saline irrigation, Platelet rich fibrin
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Chronic Periodontitis
The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients
To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal…
- Trial name
- NCT03923829
- Testing
- Zinc Sulfate, scaling and root planing
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases
Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis
Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, driven by an imbalance between bacterial pathogens and the host immune response.
- Trial name
- NCT07813936
- Testing
- 2% Melatonin gel
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Alexandria University
Periodontitis, Adult
Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.
The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males…
- Trial name
- NCT07184268
- Testing
- full mouth non-surgical scaling
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis
Evaluation of Acacia Catechu and Low-Level Laser in the Treatmentof Stage II Periodontitis
Evaluation of Acacia catechu and Low-Level Laser in the Treatment of Stage 2 Periodontitis.
- Trial name
- LLLvsAgel (NCT06805292)
- Testing
- Acacia catechu, Low Level Laser Therapy, phase 1 therapy chronic periodontitis
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Faculty of Dental Medicine for Girls
Type 2 Diabetes Mellitus
Prolactin Levels in Type 2 Diabetic Patients With Stage III Periodontitis
evaluate the role of prolactin hormone in the pathogenesis of periodontitis by assessing its local gingival levels and assess clinical parameters in patients who have type two diabetes
- Trial name
- prolactin (NCT06941246)
- Testing
- Non Surgical Periodontal Treatment, paper points, ELISA Kits
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Stage III Periodontitis
Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis.
Periodontitis is a chronic multifactorial inflammatory disorder affecting the periodontium, often implicated with microbial dysbiosis.
- Trial name
- NCT07859358
- Testing
- Injectable Platelet-Rich Fibrin (i-PRF, Peroxoborate Oxygen-Releasing Oral Gel, Sterile 0.9% Saline Solution
- Where
- 2 sites in Egypt
- Volunteers
- 24 people
- Sponsor
- Assiut University
Periodontitis, Subgingival Plaque
Comparative Evaluation of Minimally Invasive Nonsurgical Periodontal Therapy Versus Conventional Subgingival Instrumentation
Background- The use of minimally invasive procedures has recently been advocated for the treatment of periodontitis, to minimize patient discomfort and maximize the healing potential.
- Trial name
- NCT05876455
- Testing
- Conventional Subgingival Instrumentation, minimally invasive non-surgical periodontal therapy
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis Stage II, Periodontitis Stage III
Development and Validation of the Periodontal Map Derived From IOS and CBCT Registration for Diagnosis and Treatment Planning in Moderate-to-severe Periodontitis
This prospective diagnostic study aims to validate the clinical utility of a "Periodontal Panoramic Map" generated by the PerioAI V2.0 system, an artificial intelligence-based platform that integrates intraoral scans and…
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis Stage IV
- Trial name
- NCT07505251
- Testing
- Perio AI V2.0 System
- Volunteers
- 80 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Periodontitis
Impact of Supracrestal Tissue Attachment Dimension on Outcome of Scaling and Root Planing and Open Flap Debridement Procedure in Different Periodontal Phenotypes
The existence of supracrestal tissue attachment (SCTA) is fundamental for adhesion of the junctional epithelium and insertion of the connective fibers to the dental structure, besides functioning as a barrier against microbial…
- Trial name
- NCT05696600
- Testing
- Scaling and root planing and open flap debridement
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis Stage II
The Effect of Locally Dilvered Ciprofloxacine Loaded Injectable Platelet-rich Fibrin as an Adjunct to Non-surgical Periodontal Therapy on the Gingival Crevicular Level of Interleukin 6
Sixty periodontally diseased patients will be enrolled in the study. After the patients are randomly divided into one of three treated groups, group 1 (n=20), SRP only; group 2 (n=20), SRP + i-PRF; and group 3 (n=20), P +…
- Trial name
- PRF & CIP-iPRF (NCT06968286)
- Testing
- SRP, SRP+Injectable platelet rich fibrin, SRP+ciprofloxacine loaded iPRF
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Periodontal Pocket
Evaluation of 2%Bromelain Gel With 0.2%CHX Gel as Subgingival LDD Following SRP in Stage II/III and Grade B Periodontitis -A RCT
The current study is a prospective randomised study Evaluation of 2%Bromelain Gel With 0.2%Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing in Stage II/III and Grade B Periodontitis
- Trial name
- NCT06505759
- Testing
- Bromelain gel, chlorhexidine gel, SRP
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Intrabony Periodontal Defect
Clinical Effect of APRF With DFDBA Compare to Collagen Membrane With DFDBA in Intraosseous Defect
to assess the effectiveness of advanced PRF in combination of Demineralized freeze-dried bone allograft (DFDBA) as compared to collagen membrane in combination with Demineralized freeze-dried bone allograft (DFDBA) treatment of…
- Trial name
- NCT03922503
- Testing
- Advanced- platelets rich fibrin (A-PRF) with Demineralized freeze-dried bone allograft (DFDBA), Collagen membrane with Demineralized freeze-dried bone allograft (DFDBA)
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Diabetes
Local Delivery of Lactobacillus Reuteri Probiotic as An Adjunct to Non-surgical Periodontal Therapy in Patients With Stage II, III, and IV Periodontitis and Type 2 Diabetes Mellitus
The purpose of the study is to evaluate the effectiveness of local delivery of Lactobacillus reuteri probiotic on periodontitis patients with type 2 diabetes mellitus, as an adjunct to non-surgical periodontal treatment.
- Trial name
- NCT07598656
- Testing
- Lactobacillus reuteri DSM 17938, Distilled water
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Periodontitis, Periodontitis Stage II
Spirulina Gel in the Treatment of Periodontitis
This randomized clinical trial aims to evaluate the clinical and immunological effects of locally delivered Spirulina gel as an adjunct to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis.
- Trial name
- non (NCT07893587)
- Testing
- spirulina gel exracted by 1.5% calcium chloride (CaCl2) aqueous solution., conventional scaling and root planing
- Volunteers
- 20 people
- Sponsor
- Misr University for Science and Technology
Periodontal Disease
Estimation of Sialic Acid and IL10 Levels in Stage 1 and 2 Periodontitis Patients
Sialic acid (SA) is the generic term given to a family of acetylated derivatives of neuraminic acid. SA is a 9 carbon monosaccharide. An important function of host SA is to regulate innate immunity.
- Trial name
- NCT03775967
- Testing
- sialic acid, IL10
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ajman University
Periodontitis
Novel Bone Substitute (ALBO-OS) in Patients With Periodontal Disease or Who Need Alveolar Preservation
The recent Global Burden of Disease Study indicates that severe periodontitis is the 6th most prevalent disease worldwide, with an overall prevalence of 11.2% and around 743 million people affected, and the global burden of…
- Trial name
- NCT07500961
- Testing
- Albo Os
- Where
- Bosnia and Herzegovina
- Volunteers
- 20 people
- Sponsor
- Albos d.o.o. Beograd